Impact of ∼omics in the detection and validation of potential anti-infective drugs.

Abstract:

:New anti-infective drugs are an unmet necessity of modern medicine. The use of ∼omics technologies has exponentially increased the knowledge on active anti-infective structures, where to search for them and their mechanisms of action. Research involving extreme and unique environments (such as endophytes) revealed their potential for many yet unknown active molecules. This work intends to review a recent research involving discovery of secondary metabolites with an established anti-infective action which was mediated by one of the ∼omics sciences: genomics, proteomics, transcriptomics, metabolomics, glycomics or their combinations, as well as the software at the base of these discoveries.

journal_name

Curr Opin Pharmacol

authors

Maldonado-Carmona N,Vázquez-Hernández M,Patiño Chávez OJ,Rodríguez-Luna SD,Jiménez Rodríguez O,Sanchez S,Ceapă CD

doi

10.1016/j.coph.2019.02.008

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

1-7

eissn

1471-4892

issn

1471-4973

pii

S1471-4892(18)30134-6

journal_volume

48

pub_type

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