Abstract：
:Immunotherapies revolutionised the treatment of several disorders but show specific side-effect profiles which frequently involve psychological symptoms. Long term interferon-alpha (IFN-alpha) therapy can cause wide-ranging psychiatric side-effects from fatigue, insomnia, anxiety to full-blown depression. This treatment-emergent depression shares several symptoms with major depressive disorder (MDD) with a predominance of somatic/neurovegetative symptoms, and can be treated with antidepressants. However, this experience directed research to inflammatory mechanisms in MDD. MDD has been confirmed as a heterogeneous disorder with a subgroup of patients suffering from low-grade chronic inflammation and frequently resistant to traditional antidepressant treatment. Thus future research should develop strategies to identify those MDD patients who could benefit from drugs acting through inflammatory pathways.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Kovacs D,Kovacs P,Eszlari N,Gonda X,Juhasz Gdoi
10.1016/j.coph.2016.06.008subject
Has Abstractpub_date
2016-08-01 00:00:00pages
97-103eissn
1471-4892issn
1471-4973pii
S1471-4892(16)30057-1journal_volume
29pub_type
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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doi：10.1016/j.coph.2005.10.008
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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abstract：:Antimicrobial resistance is a global threat to the management of infections in our patients. Sound stewardship of antibacterial agents at our disposal must be accompanied by a concerted effort to develop new agents to bolster our armamentarium. This review will cover the latest antibiotics that have come through the p...
journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2011.02.005
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