Abstract：
:Reactive oxygen species play important roles in the pathophysiology of chronic heart failure secondary to chronic left ventricular hypertrophy or myocardial infarction. Reactive oxygen species influence several components of the phenotype of the failing heart, including contractile function, interstitial fibrosis, endothelial dysfunction and myocyte hypertrophy. Recent studies implicate the production of reactive oxygen species by a family of NADPH oxidases in these effects. NADPH oxidases are activated in an isoform-specific manner by many pathophysiological stimuli and exert distinct downstream effects. Understanding NADPH oxidase activation and regulation, and their downstream effectors, could help to develop novel therapeutic targets.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Murdoch CE,Grieve DJ,Cave AC,Looi YH,Shah AMdoi
10.1016/j.coph.2005.10.008keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
148-53issue
2eissn
1471-4892issn
1471-4973pii
S1471-4892(06)00021-Xjournal_volume
6pub_type
杂志文章,评审abstract：:Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the...
journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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abstract：:Nitric oxide (NO) produced by the enteric nervous system represents an important regulatory mechanism in gut homeostasis. Aberrant NO signaling contributes significantly toward enteric disease by altering gut motility, vascular tone, blood supply, mucosal barrier function, secretions and immunity. Consequently, there ...
journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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abstract：:After a decade of intense pharmacological and drug development activity by the pharmaceutical industry, compounds derived from two key strategies for reducing gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been subjected to rigorous clinical appraisal. Despite the undoubted therapeutic...
journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2008.06.012
更新日期：2008-08-01 00:00:00
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journal_title：Current opinion in pharmacology
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doi：10.1016/j.coph.2005.02.005
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journal_title：Current opinion in pharmacology
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doi：10.1016/j.coph.2018.07.008
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2012.12.001
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journal_title：Current opinion in pharmacology
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abstract：:Extracellular matrix (ECM) components, commonly thought to function purely as structural elements are now demonstrated to act as signaling molecules. With the identification of matrix-derived endogenous ligands of Toll-like and NOD-like receptors of innate immunity, a general question about the mechanisms of soluble E...
journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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abstract：:The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-1 reverse transcriptase and are classified into generations depending on their discovery and resistance profiles. The NNRTIs are used in combination regimens with antiretroviral agents that target two or more enzymes in the v...
journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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