Abstract：
:Neurodegenerative diseases represent a large group of neurological disorders with heterogeneous clinical and pathological profiles. The majority of current therapeutic strategies provide temporary symptomatic relief but do not target the underlying disease pathobiology and thus do not affect disease progression. G protein-coupled receptors (GPCRs) are among the most successful targets for therapeutic development of central nervous system (CNS) disorders. Many current clinical therapeutic agents act by targeting this class of receptors and downstream signaling pathways. Here, we review evidence that perturbation of GPCR function contributes to the pathophysiology of various neurodegenerative diseases, including Alzheimer's disease, Frontotemporal dementia, Vascular dementia, Parkinson's disease, and Huntington's disease.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Huang Y,Todd N,Thathiah Adoi
10.1016/j.coph.2017.02.001subject
Has Abstractpub_date
2017-02-01 00:00:00pages
96-110eissn
1471-4892issn
1471-4973pii
S1471-4892(17)30024-3journal_volume
32pub_type
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