Abstract:
:Neuromuscular blocking drugs were introduced into clinical practice in 1942. Although these drugs made new surgical techniques possible, they also led to morbidity and mortality owing to respiratory muscle paralysis and paralysis in the face of inadequate anesthesia. Newer competitive antagonists at the neuromuscular junction have been developed that have a more rapid onset of action, including rocuronium and mivacurium, making them suitable for use at the onset of anesthesia. Rapid titratable offset of action has been more difficult to achieve, but has been attempted with the inclusion of ester bonds (mivacurium) and binding agents that are in clinical trials. These novel approaches to pharmaceuticals, along with improved understanding of the physiology of the neuromuscular junction in health and disease, have made surgical treatment possible in a wide breadth of clinical situations.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Flood Pdoi
10.1016/j.coph.2004.12.009keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
322-7issue
3eissn
1471-4892issn
1471-4973pii
S1471-4892(05)00046-9journal_volume
5pub_type
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::Recent advances in the management of gastric cancer, especially in the arena of chemotherapy, are paving the way for optimization of treatment that maximizes effectiveness while minimizing toxicity. The expansion of the chemotherapeutic armamentarium has led to multiple combinations of cytotoxic agents. Unfortunately,...
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