Porous silicon advances in drug delivery and immunotherapy.

abstract：:Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects in regulating mitochondrial function are emerging. Given that mitoch...

journal_title：Current opinion in pharmacology

authors： Hendriks KD,Maassen H,van Dijk PR,Henning RH,van Goor H,Hillebrands JL

更新日期：2019-04-01 00:00:00

abstract：:Sulfonylurea receptor 1 (SUR1) is a molecule with more diverse and critically important functions than previously recognized. Long viewed simply as a subunit involved in formation of a subset of K(ATP) channels, accumulating evidence indicates that SUR1 is newly upregulated in CNS ischemia and injury and is surprising...

journal_title：Current opinion in pharmacology

authors： Simard JM,Woo SK,Bhatta S,Gerzanich V

更新日期：2008-02-01 00:00:00

abstract：:The first therapeutic aptamer was approved for human use in 2004, and a range of chemical substitutions that improve the drug-like properties of aptamers has recently been shown to increase the utility of this modality. Currently there are both anticoagulant and antithrombotic aptamers in the clinic, and additionally ...

journal_title：Current opinion in pharmacology

authors： Keefe AD,Schaub RG

更新日期：2008-04-01 00:00:00

abstract：:Stroke and multiple sclerosis (MS) illustrate how clinical imaging can facilitate early phase drug development and most effective medicine use in the clinic. Imaging has enhanced understanding of the dynamics of evolution of disease pathophysiology, better defining treatment targets. Imaging measures can enable strati...

journal_title：Current opinion in pharmacology

authors： Matthews PM,Geraghty OC

更新日期：2014-02-01 00:00:00

abstract：:High occurrence of penicillin-resistant and multidrug-resistant Streptococcus pneumoniae and reports of resistance with Haemophilus influenzae and Moraxella catarrhalis are influencing the empiric treatment of community-acquired respiratory infections and allowing the new fluoroquinolones to serve as important treatme...

journal_title：Current opinion in pharmacology

authors： Zhanel GG,Noreddin AM

更新日期：2001-10-01 00:00:00

abstract：:Prostate cancer risk can be modified by environmental factors, however the molecular mechanisms affecting susceptibility to this disease are not well understood. As a result of a series of recently published studies, the steroidal lipid, cholesterol, has emerged as a clinically relevant therapeutic target in prostate ...

journal_title：Current opinion in pharmacology

authors： Pelton K,Freeman MR,Solomon KR

更新日期：2012-12-01 00:00:00

abstract：:Although only 5-10% of patients with asthma are relatively unresponsive to treatment with inhaled corticosteroids, refractory asthma represents an important condition, as these patients suffer considerable morbidity and mortality and consume a disproportionately large amount of health resource. Treatment options are l...

journal_title：Current opinion in pharmacology

authors： Berry M,Brightling C,Pavord I,Wardlaw A

更新日期：2007-06-01 00:00:00

abstract：:Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating...

journal_title：Current opinion in pharmacology

authors： Marcelin G,Chua S Jr

更新日期：2010-10-01 00:00:00

abstract：:Despite multiple efforts to find treatments, prion diseases are still incurable. The currently available therapeutic strategies are mostly based on compounds to inhibit pathological PrP (PrPSc) accumulation, and cellular PrP (PrPC) conversion into PrPSc. However, they cannot reverse the pathological changes already pr...

journal_title：Current opinion in pharmacology

authors： Relaño-Ginés A,Lehmann S,Crozet C

更新日期：2019-02-01 00:00:00

abstract：:The CD28 and B7 protein families are critical regulators of immune responses and, in the past few years, several new family members have been identified. Preclinical studies exploring the role of members of the CD28 and B7 families support the targeting of these pathways for new therapeutic approaches. Indeed, recent ...

journal_title：Current opinion in pharmacology

authors： Carreno BM,Carter LL,Collins M

更新日期：2005-08-01 00:00:00

abstract：:About one third of people in the world suffer from metabolic syndrome (MetS), with symptoms such as hypertension and elevated blood cholesterol, and with increased risk of developing additional diseases such as diabetes mellitus and heart disease. The progression of this multifactorial pathology, which targets various...

journal_title：Current opinion in pharmacology

authors： Lugnier C

更新日期：2011-12-01 00:00:00

abstract：:Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins. Given the fact that structurally not related compounds cause an identical phenotype pinpoints to common targets or pathways, responsible for executing rhabdomyoly...

journal_title：Current opinion in pharmacology

authors： Hohenegger M

更新日期：2012-06-01 00:00:00

abstract：:Monoclonal antibodies have been used successfully to elucidate the roles of putative mediators of pulmonary disease. In particular, clinical trials with monoclonal antibodies directed against interleukin-5, IgE or CD4 yielded results that were critical in dissecting the pathophysiology of asthma; but, more importantly...

journal_title：Current opinion in pharmacology

authors： Torphy TJ,Li L,Griswold DE

更新日期：2001-06-01 00:00:00

abstract：:It has been a few decades since Ca(2+) was identified as one of the important factors that can accelerate gastric wound repair as well as contribute to epithelial homeostasis and regulation of gastric secretions. The mechanistic basis has remained largely unexplored in vivo because it was not possible to track in real...

journal_title：Current opinion in pharmacology

authors： Aihara E,Montrose MH

更新日期：2014-12-01 00:00:00

abstract：:The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease. We review the pros and cons of intestinal organoid culture systems. The molecular and gen...

journal_title：Current opinion in pharmacology

authors： Tsakmaki A,Fonseca Pedro P,Bewick GA

更新日期：2017-12-01 00:00:00

abstract：:The neuroepithelial bodies (NEB) of the intrapulmonary airways (AW) are multimodal AW sensors responding to a variety of stimuli including hypoxia, hypercarbia, and mechanical stretch. NEBs are richly innervated by a diverse population of mostly vagal afferent nerve fibers and owing to their early developmental matura...

journal_title：Current opinion in pharmacology

authors： Domnik NJ,Cutz E

更新日期：2011-06-01 00:00:00

abstract：:Adiponectin, a novel hormone made by fat tissue, regulates energy metabolism and endothelial activation. Serum levels of adiponectin are reduced in conditions that are associated with an increased risk of cardiovascular disease, such as diabetes and the metabolic syndrome. Adiponectin trimers assemble into higher-orde...

journal_title：Current opinion in pharmacology

authors： Hug C,Lodish HF

更新日期：2005-04-01 00:00:00

abstract：:Inhibition is a fundamental property of behaviour required for flexible responding and humans have evolved executive brain systems that can engage inhibitory processes in order to reduce interference from irrelevant distracting stimuli, block unwanted memories and emotions and suppress inappropriate choices and action...

journal_title：Current opinion in pharmacology

authors： Humby T,Wilkinson LS

更新日期：2011-10-01 00:00:00

abstract：:The repertoire of signal transduction pathways activated by dopamine in brain includes the increase of intracellular calcium. However the mechanism(s) by which dopamine activated this important second messenger system was/were unknown. Although we showed that activation of the D5 dopamine receptor increased calcium co...

journal_title：Current opinion in pharmacology

authors： Hasbi A,O'Dowd BF,George SR

更新日期：2010-02-01 00:00:00

abstract：:Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection and inflammation to provide early defence against invading microorganisms. This function is facilitated by the expression of Toll-like receptor (TLR) family members by neutrophils, allowing the recognition of an extensive...

journal_title：Current opinion in pharmacology

authors： Prince LR,Whyte MK,Sabroe I,Parker LC

更新日期：2011-08-01 00:00:00

abstract：:A complex network operates in the spinal dorsal horn to integrate peripheral nociceptive inputs with local and descending control mechanisms, and to cross-talk with higher brain areas. Injury to peripheral sensory nerves can trigger a cascade of events within this relay which, in some cases, may turn into abnormal res...

journal_title：Current opinion in pharmacology

authors： Berliocchi L,Russo R,Tassorelli C,Morrone LA,Bagetta G,Corasaniti MT

更新日期：2012-02-01 00:00:00

abstract：:Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol. ChEH is a hetero-oligomeric complex called the anti-estrogen binding site (AEBS) comprising 3β-hydroxysterol-Δ(8)-Δ(7)-isomerase (D8D7I) and 3β-hydroxysterol-Δ(7)-reductase (DHCR7). D8D7I a...

journal_title：Current opinion in pharmacology

authors： Silvente-Poirot S,Poirot M

更新日期：2012-12-01 00:00:00

abstract：:There have been significant developments in Ebola virus therapeutics. While the efficacy of several products was evaluated in the recent West Africa outbreak, a licensed treatment for EBOV disease remains elusive. Factors that negatively impacted the execution of clinical trials included an overall lack of world readi...

journal_title：Current opinion in pharmacology

authors： Cardile AP,Downey LG,Wiseman PD,Warren TK,Bavari S

更新日期：2016-10-01 00:00:00

abstract：:Chronic inflammation is a risk factor for several gastrointestinal malignancies, including colorectal cancer. Recent epidemiological studies and clinical trials demonstrate that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) markedly reduced the relative risk of colorectal cancer. Chronic inflammation...

journal_title：Current opinion in pharmacology

authors： Wang D,Dubois RN,Richmond A

更新日期：2009-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to morbidity and mortality in patients with cystic fibrosis. Defective mucociliary clearance associated with the absence of the functional cystic fibrosis transmembrane conductance regulator in airway epithelium plays a critical role in...

journal_title：Current opinion in pharmacology

authors： Gómez MI,Prince A

更新日期：2007-06-01 00:00:00

abstract：:In recent decades there has been an upsurge of interest in mechanisms of cell death in the central nervous system. Much attention has been focused on two cell death processes - excitotoxicity and apoptosis - and much confusion has arisen regarding how one relates to the other, and how either relates to neurological di...

journal_title：Current opinion in pharmacology

authors： Olney JW

更新日期：2003-02-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is the most common form of the interstitial lung diseases and is characterized by chronic progressive pulmonary parenchymal fibrosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there remains no effective therapy for t...

journal_title：Current opinion in pharmacology

authors： Bhatt N,Baran CP,Allen J,Magro C,Marsh CB

更新日期：2006-06-01 00:00:00

abstract：:Two new approaches for the treatment of osteoporosis are summarized, each having arisen out of important new discoveries in bone biology. Odanacatib (ODN) inhibits the enzyme, cathepsin K, that is essential for the resorbing activity of osteoclasts. It is effective in preventing ovariectomy-induced bone loss in precli...

journal_title：Current opinion in pharmacology

authors： Ng KW,Martin TJ

更新日期：2014-06-01 00:00:00

abstract：:Neuropsychiatric disorders as schizophrenia, autism and mood disorders represent one of the leading causes of disability. The cost of bringing a drug to the market is increasing and becoming more risky. Pharmaceutical investments in neuroscience are decreasing. At the same time we are facing an unprecedented rate of d...

journal_title：Current opinion in pharmacology

authors： Muglia P

更新日期：2011-10-01 00:00:00

abstract：:Chemokines in the brain have been recognised as essential elements in neurodegenerative diseases and related neuroinflammation. Recent studies suggest that in addition to the orchestration of chemotaxis of immune cells, chemokines are also involved in neurodevelopment and neurophysiological signalling. ...

journal_title：Current opinion in pharmacology

authors： Biber K,Zuurman MW,Dijkstra IM,Boddeke HW

更新日期：2002-02-01 00:00:00