Abstract：
:Cachexia is a multi-organ syndrome associated with cancer and other chronic diseases, characterized by body weight loss, muscle and adipose tissue wasting and inflammation, being often associated with anorexia. Skeletal muscle tissue represents more than 40% of body weight and seems to be one of the main tissues involved in the wasting that occurs during cachexia. Sarcopenia is a degenerative loss of skeletal muscle mass, quality, and strength associated with healthy ageing. The molecular mechanisms behind cachexia and sarcopenia share some common trends. Muscle wasting is the result of a combination of an imbalance between synthetic and degradative protein pathways together with increased myocyte apoptosis and decreased regenerative capacity. Oxidative pathways are also altered in skeletal muscle during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling. The aim of the present review is to analyse common molecular pathways between cachexia and sarcopenia in order to put forward potential targets for intervention.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Argilés JM,Busquets S,Stemmler B,López-Soriano FJdoi
10.1016/j.coph.2015.04.003subject
Has Abstractpub_date
2015-06-01 00:00:00pages
100-6eissn
1471-4892issn
1471-4973pii
S1471-4892(15)00040-5journal_volume
22pub_type
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