Abstract：
:In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future anti-hypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Sumners C,de Kloet AD,Krause EG,Unger T,Steckelings UMdoi
10.1016/j.coph.2015.01.004subject
Has Abstractpub_date
2015-04-01 00:00:00pages
115-21eissn
1471-4892issn
1471-4973pii
S1471-4892(15)00005-3journal_volume
21pub_type
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