Abstract:
:Circadian rhythms impact cardiac and vascular pathophysiology, resulting in 24-hour patterning of symptoms and life-threatening/ending events (chronopathology), plus kinetics and dynamics of medications (chronopharmacology), resulting in administration-time differences in efficacy and safety. Scheduling medications according to circadian rhythm determinants (chronotherapy) can improve treatment effects, for example, before dinner/bedtime ingestion of cholesterol-lowering medications and acetylsalicylic acid, respectively, exerts enhanced control of hypercholesterolemia and after-awakening peak of platelet aggregation; bedtime ingestion of conventional hypertension medications optimizes normalization of sleep-time blood pressure (BP)-strongest independent BP marker of cardiovascular disease (CVD) risk-and most effectively prevents (chronoprevention) CVD morbidity and mortality. Exploration of chronotherapeutic strategies to improve management of cardiac arrhythmias and vascular pathophysiology is still awaited.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Smolensky MH,Hermida RC,Geng YJdoi
10.1016/j.coph.2020.10.014subject
Has Abstractpub_date
2020-12-03 00:00:00pages
41-48eissn
1471-4892issn
1471-4973pii
S1471-4892(20)30117-Xjournal_volume
57pub_type
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