Nanotechnology in pulmonary medicine.

Abstract:

:Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to address historical clinical challenges in pulmonary diseases including multidrug resistance, adverse side effects of conventional therapeutic agents, novel imaging, and earlier disease detection. Nanomedicine is also being applied to tackle the new emerging infectious diseases, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), influenza A virus subtype H1N1 (A/H1N1), and more recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review we provide both a historical overview of the application of nanomedicine to respiratory diseases and more recent cutting-edge approaches such as nanoparticle-mediated combination therapies, novel double-targeted nondrug delivery system for targeting, stimuli-responsive nanoparticles, and theranostic imaging in the diagnosis and treatment of pulmonary diseases.

journal_name

Curr Opin Pharmacol

authors

Doroudian M,O' Neill A,Mac Loughlin R,Prina-Mello A,Volkov Y,Donnelly SC

doi

10.1016/j.coph.2020.11.002

subject

Has Abstract

pub_date

2020-12-17 00:00:00

pages

85-92

eissn

1471-4892

issn

1471-4973

pii

S1471-4892(20)30129-6

journal_volume

56

pub_type

杂志文章,评审
  • Death in pain: peripheral nerve injury and spinal neurodegenerative mechanisms.

    abstract::A complex network operates in the spinal dorsal horn to integrate peripheral nociceptive inputs with local and descending control mechanisms, and to cross-talk with higher brain areas. Injury to peripheral sensory nerves can trigger a cascade of events within this relay which, in some cases, may turn into abnormal res...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2011.10.021

    authors: Berliocchi L,Russo R,Tassorelli C,Morrone LA,Bagetta G,Corasaniti MT

    更新日期:2012-02-01 00:00:00

  • CFTR pharmacology and its role in intestinal fluid secretion.

    abstract::The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) channel expressed in epithelial cells in the airways, pancreas, intestine and other fluid-transporting tissues. Cystic fibrosis is caused by mutations in the CFTR, resulting in impaired Cl(-) transport and plasma membrane targetin...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2003.06.012

    authors: Thiagarajah JR,Verkman AS

    更新日期:2003-12-01 00:00:00

  • The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease.

    abstract:PURPOSE OF THE REVIEW:Faecal microbiota transplantation (FMT) has emerged as a potent form of therapeutic microbial manipulation. There is much interest in exploring its potential in conditions such as inflammatory bowel disease (IBD) where disturbances in the gastrointestinal microbiota play a crucial role in disease ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2020.08.009

    authors: Haifer C,Leong RW,Paramsothy S

    更新日期:2020-12-01 00:00:00

  • New approaches to targeting the bone marrow microenvironment in multiple myeloma.

    abstract::Multiple myeloma is a tumour with a remarkably destructive effect on its host organ, the bone marrow. Through expression or secretion of adhesion molecules, growth factors, exosomes, miRNAs, chemokines and inhibitors, the tumour substantially alters its microenvironment, promoting both tumour survival and osteolytic b...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2016.02.013

    authors: Gooding S,Edwards CM

    更新日期:2016-06-01 00:00:00

  • Neurotrophic effects of antidepressant drugs.

    abstract::The past decade has witnessed a growing interest in the trophic effects of antidepressant drugs. Antidepressants stimulate the production and signaling of plasticity-related proteins such as neurotrophins and cAMP response element binding protein, and neurotrophin signaling appears to be both sufficient and necessary ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2003.10.004

    authors: Castrén E

    更新日期:2004-02-01 00:00:00

  • Aptamers as candidate therapeutics for cardiovascular indications.

    abstract::The first therapeutic aptamer was approved for human use in 2004, and a range of chemical substitutions that improve the drug-like properties of aptamers has recently been shown to increase the utility of this modality. Currently there are both anticoagulant and antithrombotic aptamers in the clinic, and additionally ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2007.12.005

    authors: Keefe AD,Schaub RG

    更新日期:2008-04-01 00:00:00

  • Receptor classification: post genome.

    abstract::Most of the G-protein-coupled receptors (GPCRs) in the human genome have been described. Investigation will now shift from discovery to analysis. Like many other genes, those encoding GPCRs are frequently found adjacent to each other in clusters. Duplicated genes often share ligands, signalling pathways and amino acid...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1471-4892(02)00214-x

    authors: Foord SM

    更新日期:2002-10-01 00:00:00

  • In silico models in drug development: where we are.

    abstract::The use and utility of computational models in drug development has significantly grown in the last decades, fostered by the availability of high throughput datasets and new data analysis strategies. These in silico approaches are demonstrating their ability to generate reliable predictions as well as new knowledge on...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2018.08.007

    authors: Piñero J,Furlong LI,Sanz F

    更新日期:2018-10-01 00:00:00

  • The abandonment of antibacterials: why and wherefore?

    abstract::The pharmaceutical industry is currently abandoning its antibacterial discovery research efforts. This seems to be part of a cyclical pattern in this therapeutic area. The reasons behind these ongoing cycles of feast and famine are multiple, but most revolve around the perception of market opportunities from the conti...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2003.04.003

    authors: Shlaes DM

    更新日期:2003-10-01 00:00:00

  • Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis.

    abstract::Oxidation-specific epitopes (OSE), present on oxidized LDL (OxLDL), apoptotic cells, cell debris and modified proteins in the vessel wall, accumulate in response to hypercholesterolemia, and generate potent pro-inflammatory, disease-specific antigens. They represent an important class of 'danger associated molecular p...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2013.02.005

    authors: Leibundgut G,Witztum JL,Tsimikas S

    更新日期:2013-04-01 00:00:00

  • Capsules with external navigation and triggered release.

    abstract::Encapsulation is an important technology for pharmaceutical industry, food production, et cetera. Its current level of development requires capsule functionalization. One of the interesting ideas to provide new functionality to the microcapsule and nanocapsule is layer-by-layer deposition of functional species. This t...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2014.09.002

    authors: Shchukin DG,Shchukina E

    更新日期:2014-10-01 00:00:00

  • MicroRNA involvement in esophageal carcinogenesis.

    abstract::MicroRNAs (miRs) have recently emerged as a novel class of gene expression regulators. The number of studies documenting an altered miR expression pattern in cancer continues to expand rapidly. Critical information is continuously gained regarding how aberrantly expressed miRs contribute to carcinogenesis. Current stu...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2011.09.006

    authors: David S,Meltzer SJ

    更新日期:2011-12-01 00:00:00

  • Opioid receptor signaling: relevance for gastrointestinal therapy.

    abstract::Opiate drugs, such as morphine, are renowned for their analgesic properties. To date, opioid narcotics represent the largest and most potent class of pain relievers available to treat both acute and chronic pain conditions. The use of opiates, however, is severely limited by several adverse side effects. Upon chronic ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2006.06.007

    authors: Bohn LM,Raehal KM

    更新日期:2006-12-01 00:00:00

  • Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen/aromatase inhibitors.

    abstract::Several mechanisms of resistance have been identified, underscoring the complex nature of estrogen receptor (ER) signaling and the many connections between this pathway and other essential signaling pathways in breast cancer cells. Many therapeutic targets of cell signaling and cell cycle pathways have met success wit...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2018.04.009

    authors: Mills JN,Rutkovsky AC,Giordano A

    更新日期:2018-08-01 00:00:00

  • Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?

    abstract::Inverse agonism has gone from an initial curiosity to a now well-recognized phenomenon. This has demanded expansion of receptor theory models to account for multiple receptor states and a re-definition of ligand efficacy. However, after several decades of discovery, the clinical importance of inverse agonist ligands i...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2006.10.005

    authors: Parra S,Bond RA

    更新日期:2007-04-01 00:00:00

  • The bacterial ribosome, a promising focus for structure-based drug design.

    abstract::Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be use...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1471-4892(02)00205-9

    authors: Knowles DJ,Foloppe N,Matassova NB,Murchie AI

    更新日期:2002-10-01 00:00:00

  • Antibody therapy for rheumatoid arthritis.

    abstract::High-quality monoclonal antibodies (mAbs) with specificity for relevant disease molecules can now be produced in abundance. Anti-tumour necrosis factor-alpha therapies have set a new standard for symptom control in rheumatoid arthritis, and blockade of tumour necrosis factor has the potential to protect joints from st...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1471-4892(03)00032-8

    authors: Taylor PC

    更新日期:2003-06-01 00:00:00

  • From purified GPCRs to drug discovery: the promise of protein-based methodologies.

    abstract::G-protein-coupled receptors (GPCRs), the largest family of membrane proteins, represent ideal therapeutic targets for a number of disorders and diseases. Besides cell-based assays and high throughput screening (HTS), and thanks to the availability of milligram quantities of active purified receptors, protein-based app...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2009.04.002

    authors: Alkhalfioui F,Magnin T,Wagner R

    更新日期:2009-10-01 00:00:00

  • Genomic landscape analyses in cervical carcinoma and consequences for treatment.

    abstract::Where we are on the road to 'tailor-made' precision medicine for drug-resistant cervical carcinoma? We explored studies about analyses of viral and human genomes, epigenomes and transcriptomes, DNA mutation analyses, their importance in detecting HPV sequences, mechanisms of drug resistance to established and targeted...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2020.09.013

    authors: Diefenbach D,Greten HJ,Efferth T

    更新日期:2020-10-01 00:00:00

  • Role of HMGB1 in cardiovascular diseases.

    abstract::A nuclear protein, high mobility group box 1 (HMGB1), is released passively by necrotic cells, and actively by macrophages/monocytes in response to exogenous and endogenous inflammatory stimuli. After binding to the receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4), HMGB1 activates vas...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2005.10.010

    authors: Li W,Sama AE,Wang H

    更新日期:2006-04-01 00:00:00

  • Retrieving GPCR data from public databases.

    abstract::Improvements in databases have already impacted GPCR research. The purpose of the review is to give a snapshot of the GPCR data available and provide utility examples. Consequently, this review covers a small set of major databases, including UniProt for proteins, Ensembl for genes, ChEMBL for bioactive chemistry and ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2016.07.002

    authors: Southan C

    更新日期:2016-10-01 00:00:00

  • New developments in Toll-like receptor targeted therapeutics.

    abstract::Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a significant amount of evidence implicates TLRs in the pathogenesis of immune diseases and cancer, and their activation occurs early in the inflammatory cascade, they are attractive targets for novel therapeutic agents. Potent...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2012.06.002

    authors: Connolly DJ,O'Neill LA

    更新日期:2012-08-01 00:00:00

  • Recent advances in the non-invasive assessment of fibrosis using biomarkers.

    abstract::Fibrosis can occur in most organs and is characterised by excessive and progressive extracellular matrix deposition and destruction of normal tissue architecture and function. In many cases treatment options are limited. Fibrotic diseases are therefore associated with high morbidity and mortality. Tissue biopsies rema...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2019.09.010

    authors: Tatler AL

    更新日期:2019-12-01 00:00:00

  • Clinical effectiveness of novel rosacea therapies.

    abstract::Rosacea is a common inflammatory skin disease that is difficult to manage because of the unknown etiology and due to its variable manifestations. These facts and the few new available treatment options make it difficult to select a really effective treatment. This review aims to assess the efficacy and safety of novel...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2018.12.001

    authors: Feaster B,Cline A,Feldman SR,Taylor S

    更新日期:2019-06-01 00:00:00

  • Biased ligands: pathway validation for novel GPCR therapeutics.

    abstract::G protein-coupled receptors (GPCRs), in recent years, have been shown to signal via multiple distinct pathways. Furthermore, biased ligands for some receptors can differentially stimulate or inhibit these pathways versus unbiased endogenous ligands or drugs. Biased ligands can be used to gain a deeper understanding of...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2014.04.002

    authors: Rominger DH,Cowan CL,Gowen-MacDonald W,Violin JD

    更新日期:2014-06-01 00:00:00

  • Neurobiology of craving, conditioned reward and relapse.

    abstract::Chronic vulnerability to relapse is a formidable challenge for the treatment of drug addiction. The neurobiological basis of relapse and its prevention has, therefore, attracted major attention in addiction research. Current conceptualizations of addiction recognize craving as a central driving force for ongoing drug ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2004.11.001

    authors: Weiss F

    更新日期:2005-02-01 00:00:00

  • Airway nerves: in vivo electrophysiology.

    abstract::Information about the activity of airway sensory afferent nerves in vivo can be obtained electrophysiologically by extracellular recording of action potentials. Apart from data capture, the basic techniques used for recording sensory nerve activity have not advanced greatly in 50 years. However, clearly they continue ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1471-4892(02)00153-4

    authors: Adcock JJ

    更新日期:2002-06-01 00:00:00

  • GDNF and somatostatin in sensory neurones.

    abstract::Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, the SOM stable analogue octreotide (OCT) is used to treat opioid-resistant pain. In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/s1471-4892(02)00007-3

    authors: Malcangio M

    更新日期:2003-02-01 00:00:00

  • Gastroesophageal reflux disease.

    abstract::Gastroesophageal reflux disease (GERD) is increasingly common worldwide; symptoms differ between individuals and endoscopically visible injury is present in only about 50% of cases. Although GERD is a disorder of gastrointestinal motility and structure, the most effective therapy is based on the use of acid antisecret...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2005.09.001

    authors: Armstrong D

    更新日期:2005-12-01 00:00:00

  • Invasive treatment in peripheral artery disease.

    abstract::Invasive treatment in peripheral artery disease (PAD) has evolved as a viable alternative to surgical treatment. However, beyond the common pathophysiological substrate, as far as treatment is concerned, each site of atherosclerotic disease (subclavian and vertebral arteries; carotid arteries; intracranial arterial tr...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.coph.2018.01.013

    authors: Deftereos SG,Vrachatis DA,Tolis C,Giannopoulos G

    更新日期:2018-04-01 00:00:00