Abstract：
:G protein-coupled receptors (GPCRs), in recent years, have been shown to signal via multiple distinct pathways. Furthermore, biased ligands for some receptors can differentially stimulate or inhibit these pathways versus unbiased endogenous ligands or drugs. Biased ligands can be used to gain a deeper understanding of the molecular targets and cellular responses associated with a GPCR, and may be developed into therapeutics with improved efficacy, safety and/or tolerability. Here we review examples and approaches to pathway validation that establish the relevance and therapeutic potential of distinct pathways that can be selectively activated or blocked by biased ligands.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Rominger DH,Cowan CL,Gowen-MacDonald W,Violin JDdoi
10.1016/j.coph.2014.04.002subject
Has Abstractpub_date
2014-06-01 00:00:00pages
108-15eissn
1471-4892issn
1471-4973pii
S1471-4892(14)00041-1journal_volume
16pub_type
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journal_title：Current opinion in pharmacology
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