Abstract:
:In vitro surveillance data, which provide key information to interpret the results of pharmacokinetic/pharmacodynamics (PK-PD) target attainment studies, are used to support dose selection decisions and recommendations for in vitro susceptibility testing criteria for antibacterial agents during drug development. Considerations for designing the in vitro surveillance database to support the development of antibacterial agents include the choice of pathogens to study, the sample size of isolate collections needed, and target patient populations from which clinical isolates should be collected. Post-approval, global in vitro surveillance data produced by reference quality antibacterial susceptibility tests together with PK-PD target attainment analyses provide the opportunity to evaluate approved and clinically used antibacterial dosing regimens. These data enable the optimal use of antibacterial agents in an environment in which we face changing and challenging bacterial pathogens.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Flamm RK,Sader HS,Castanheira M,Jones RNdoi
10.1016/j.coph.2017.10.009subject
Has Abstractpub_date
2017-10-01 00:00:00pages
130-138eissn
1471-4892issn
1471-4973pii
S1471-4892(17)30011-5journal_volume
36pub_type
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journal_title:Current opinion in pharmacology
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