Human therapeutic antibodies.

abstract：:Reporter-gene assays offer an alternative to biochemical assays for following signal transduction pathways from receptors at the cell surface to nuclear gene transcription in living cells. Specific reporter-gene systems are now available for the study of ligand activity at G alpha(i/o), G alpha(s) and G alpha(q) G-pro...

journal_title：Current opinion in pharmacology

authors： Hill SJ,Baker JG,Rees S

更新日期：2001-10-01 00:00:00

abstract：:Blood vessels deliver nutrients and oxygen to cells and tissues in the body. When blood supply is insufficient new vessels form to meet the metabolic tissue requirements. Several studies have examined the cellular and molecular principles of blood vessel formation, yet little is known about how vessels sense and integ...

journal_title：Current opinion in pharmacology

authors： Guarani V,Potente M

更新日期：2010-04-01 00:00:00

abstract：:Nitric oxide (NO) produced by the enteric nervous system represents an important regulatory mechanism in gut homeostasis. Aberrant NO signaling contributes significantly toward enteric disease by altering gut motility, vascular tone, blood supply, mucosal barrier function, secretions and immunity. Consequently, there ...

journal_title：Current opinion in pharmacology

authors： Savidge TC

更新日期：2014-12-01 00:00:00

abstract：:The majority of kidney cancers are clear-cell carcinomas (ccRCC), characterized by the accumulation of cholesterol, cholesterol esters, other neutral lipids and glycogen. Rather than being a passive bystander, the clear-cell phenotype is suggested to be a biomarker of deregulated cholesterol and lipid biosynthesis, wh...

journal_title：Current opinion in pharmacology

authors： Drabkin HA,Gemmill RM

更新日期：2012-12-01 00:00:00

abstract：:The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-1 reverse transcriptase and are classified into generations depending on their discovery and resistance profiles. The NNRTIs are used in combination regimens with antiretroviral agents that target two or more enzymes in the v...

journal_title：Current opinion in pharmacology

authors： Vanangamudi M,Kurup S,Namasivayam V

更新日期：2020-10-01 00:00:00

abstract：:Angiotensin II blockade has become a standard anti-fibrotic therapy in renal diseases because it slows progression to end-stage renal disease. However, current data support the notion that angiotensin II blockade alone cannot stop progressive fibrotic disease. Of an increasing number of therapies showing efficacy in a...

journal_title：Current opinion in pharmacology

authors： Yu L,Noble NA,Border WA

更新日期：2002-04-01 00:00:00

abstract：:Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain transmission and inflammation and for these reasons to the mechanism of migraine. CGRP is, in fact, expressed in and released from a subset of polymodal primary sensory neurons of the trigeminal ganglion. Release of CGRP in the dorsal spina...

journal_title：Current opinion in pharmacology

authors： Benemei S,Nicoletti P,Capone JG,Geppetti P

更新日期：2009-02-01 00:00:00

abstract：:Antimicrobial resistance is a global threat to the management of infections in our patients. Sound stewardship of antibacterial agents at our disposal must be accompanied by a concerted effort to develop new agents to bolster our armamentarium. This review will cover the latest antibiotics that have come through the p...

journal_title：Current opinion in pharmacology

authors： Gould IM,Gunasekera C,Khan A

更新日期：2019-10-01 00:00:00

abstract：:Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation an...

journal_title：Current opinion in pharmacology

authors： Lidgerwood GE,Hewitt AW,Pébay A

更新日期：2019-10-01 00:00:00

abstract：:Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype o...

journal_title：Current opinion in pharmacology

authors： Inoue K

更新日期：2019-08-01 00:00:00

abstract：:Successful cancer therapy requires the selective killing of cancer cells. Many molecular components of the pathways that lead to cell death have recently been identified and a number of these, including p53, Apaf-1, and members of the inhibitor of apoptosis protein and Bcl-2 gene families, have been found to be altere...

journal_title：Current opinion in pharmacology

authors： Bunz F

更新日期：2001-08-01 00:00:00

abstract：:Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Re...

journal_title：Current opinion in pharmacology

authors： Savage DJ,Liu X,Curley SA,Ferrari M,Serda RE

更新日期：2013-10-01 00:00:00

abstract：:The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and a...

journal_title：Current opinion in pharmacology

authors： Ahern GP

更新日期：2011-02-01 00:00:00

abstract：:In vitro surveillance data, which provide key information to interpret the results of pharmacokinetic/pharmacodynamics (PK-PD) target attainment studies, are used to support dose selection decisions and recommendations for in vitro susceptibility testing criteria for antibacterial agents during drug development. Consi...

journal_title：Current opinion in pharmacology

authors： Flamm RK,Sader HS,Castanheira M,Jones RN

更新日期：2017-10-01 00:00:00

abstract：:Clostridium difficile disease is the major, known cause of nosocomial diarrhea and is an emerging cause of community-associated diarrhea. Recent outbreaks due to a strain of apparent increased virulence, BI/NAP1, and recognition of increasing metronidazole treatment failures as well as the morbidity associated with re...

journal_title：Current opinion in pharmacology

authors： Balagopal A,Sears CL

更新日期：2007-10-01 00:00:00

abstract：:Tuberculosis now ranks as the leading cause of death in the world due to a single infectious agent. Current standard of care treatment can achieve very high cure rates for drug-sensitive disease but requires a 6-month duration of chemotherapy. Drug-resistant disease requires significantly longer treatment durations wi...

journal_title：Current opinion in pharmacology

authors： J Libardo MD,Boshoff HI,Barry CE 3rd

更新日期：2018-10-01 00:00:00

abstract：:Antidepressants are among the most widely prescribed drugs, however the mechanism underlying their therapeutic efficacy is not known. Neurotrophic factors represent a promising class of targets for antidepressant treatments. We recently characterized a role for vascular endothelial growth factor (VEGF) in cellular and...

journal_title：Current opinion in pharmacology

authors： Warner-Schmidt JL,Duman RS

更新日期：2008-02-01 00:00:00

abstract：:During the past decade, evidence has accumulated for the involvement of purines and purine receptors in the pathogenesis and pathophysiology of asthma and chronic obstructive pulmonary diseases. In particular, the indirect bronchospasmic and inflammatory actions of purines via the activation and degranulation of mast ...

journal_title：Current opinion in pharmacology

authors： Adriaensen D,Timmermans JP

更新日期：2004-06-01 00:00:00

abstract：:Among the methods based on molecular imaging, the measure of the tracer uptake variation between a baseline and follow-up scan with the SUV and [(18)F]FDG-PET/CT is a very powerful tool for assessing response to treatment in oncology. However, the development of new targeted therapeutics and tissue pharmacokinetic eva...

journal_title：Current opinion in pharmacology

authors： Tomasi G,Rosso L

更新日期：2012-10-01 00:00:00

abstract：:Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) has been extensively investigated in the pre-clinical setting as a strategy for chemo- or radio-potentiation. Recent evidence has suggested that PARP inhibitors might be active as single agents in certain rare inherited cancers that carry DNA r...

journal_title：Current opinion in pharmacology

authors： Plummer ER

更新日期：2006-08-01 00:00:00

abstract：:Gut microbiota has a crucial role in the maintenance of health. Increasing evidence suggests that changes or disturbances in gut microbiota may be associated with various diseases. Therefore, preclinical and clinical studies related to gut microbiota are becoming increasingly important. Germ-free animal experimentatio...

journal_title：Current opinion in pharmacology

authors： Uzbay T

更新日期：2019-12-01 00:00:00

abstract：:Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be use...

journal_title：Current opinion in pharmacology

authors： Knowles DJ,Foloppe N,Matassova NB,Murchie AI

更新日期：2002-10-01 00:00:00

abstract：:Orthostatic hypotension (OH) is a fall in blood pressure after assuming an upright position. Whereas asymptomatic patients usually need no treatment, the majority of symptomatic patients can be cured by avoidance of trigger mechanisms and the use of physical countermaneuvers and non-pharmacological interventions. Seve...

journal_title：Current opinion in pharmacology

authors： Oldenburg O,Kribben A,Baumgart D,Philipp T,Erbel R,Cohen MV

更新日期：2002-12-01 00:00:00

abstract：:About one third of people in the world suffer from metabolic syndrome (MetS), with symptoms such as hypertension and elevated blood cholesterol, and with increased risk of developing additional diseases such as diabetes mellitus and heart disease. The progression of this multifactorial pathology, which targets various...

journal_title：Current opinion in pharmacology

authors： Lugnier C

更新日期：2011-12-01 00:00:00

abstract：:Chronic vulnerability to relapse is a formidable challenge for the treatment of drug addiction. The neurobiological basis of relapse and its prevention has, therefore, attracted major attention in addiction research. Current conceptualizations of addiction recognize craving as a central driving force for ongoing drug ...

journal_title：Current opinion in pharmacology

authors： Weiss F

更新日期：2005-02-01 00:00:00

abstract：:The metabolic syndrome constitutes a group of metabolic conditions that increase the risk of developing diseases, including cardiovascular disease (CVD) and type 2 diabetes (T2D). LXRα/β are regulators of lipogenesis, cholesterol/glucose homoeostasis and inflammatory pathways, processes that are intertwined with devel...

journal_title：Current opinion in pharmacology

authors： Faulds MH,Zhao C,Dahlman-Wright K

更新日期：2010-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to morbidity and mortality in patients with cystic fibrosis. Defective mucociliary clearance associated with the absence of the functional cystic fibrosis transmembrane conductance regulator in airway epithelium plays a critical role in...

journal_title：Current opinion in pharmacology

authors： Gómez MI,Prince A

更新日期：2007-06-01 00:00:00

abstract：:Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that ...

journal_title：Current opinion in pharmacology

authors： Clark AR,Lasa M

更新日期：2003-08-01 00:00:00

abstract：:For decades it has been thought that a neuron releases only one classical neurotransmitter from all of its processes. However, recent work has shown that most neuronal populations release more than one classical transmitter, and indeed that the transmitters can be segregated into different processes of the same neuron...

journal_title：Current opinion in pharmacology

authors： Seal RP,Edwards RH

更新日期：2006-02-01 00:00:00

abstract：:In spite of the recent advancement in the molecular characterization of malignant gliomas and medulloblastomas, the treatment of primary brain tumors remains suboptimal. The use of small molecule inhibitors of intracellular signaling pathways, inhibitors of angiogenesis, and immunotherapic agents is limited by systemi...

journal_title：Current opinion in pharmacology

authors： Iacovelli L,Orlando R,Rossi A,Spinsanti P,Melchiorri D,Nicoletti F

更新日期：2018-02-01 00:00:00