Abstract：
:Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have been genetically deleted in mice toward identifying biological and medically relevant roles. In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Noguchi K,Herr D,Mutoh T,Chun Jdoi
10.1016/j.coph.2008.11.010subject
Has Abstractpub_date
2009-02-01 00:00:00pages
15-23issue
1eissn
1471-4892issn
1471-4973pii
S1471-4892(08)00196-3journal_volume
9pub_type
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journal_title：Current opinion in pharmacology
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pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2009.07.002
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2012.01.012
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2010.05.009
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2012.03.008
更新日期：2012-08-01 00:00:00
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4892(03)00039-0
更新日期：2003-06-01 00:00:00
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2006.08.002
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2008.12.018
更新日期：2009-02-01 00:00:00
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
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abstract：:During the past few years, a possible link between skeletal muscle contractile activity and immune changes has been established. This concept is based on the finding that exercise provokes an increase in a number of cytokines. We have suggested that cytokines and other peptides that are produced; expressed and release...
journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.coph.2008.02.005
更新日期：2008-06-01 00:00:00
