Abstract:
:It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently protected than the free compound. Furthermore, release of bound quinacrine from DNA is observed at higher doses.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Hissung A,Dertinger H,Heinrich Gdoi
10.1007/BF02339804keywords:
subject
Has Abstractpub_date
1975-06-13 00:00:00pages
5-12issue
1eissn
0301-634Xissn
1432-2099journal_volume
12pub_type
杂志文章abstract::Among the various methods for studying the relative effects of transmutation and radiation of incorporated nuclides, simulation of beta radiation by external gamma exposure is of practical importance. Self-irradiation and mutual irradiation of the labeled cells cannot be neglected in any case. Furthermore, additional ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326755
更新日期:1975-01-01 00:00:00
abstract::Growing hair follicles with their rapid cell proliferation would be expected to be sensitive organs to cytotoxic agents such as radiation. Various abnormalities in the hair and hair follicles have been reported in the past. Changes in the number of cells in the newly forming hair cortex have been shown in the mouse to...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF02434035
更新日期:1996-05-01 00:00:00
abstract::Several proteins are known to form foci at DNA sites damaged by ionizing radiation. We study DNA damage response by immunofluorescence microscopy after microirradiation of cells with energetic ions. By using microirradiation, it is possible to irradiate different regions on a single dish at different time-points and t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0181-0
更新日期:2008-11-01 00:00:00
abstract::The antioxidant properties of hydroxycinnamic acid derivatives (HCA) were studied by laser flash photolysis. The transient species with maximum absorption at 360 nm were assigned to the phenoxyl radical of HCA. The SO (4) (.-) induced oxidation of HCA was also investigated. It was shown that the interaction of SO (4) ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0041-8
更新日期:2006-05-01 00:00:00
abstract::Ionizing radiation can produce adverse biological effects in astronauts during space travel. Of particular concern are the types of radiation from highly energetic, heavy, charged particles known as HZE particles. The aims of our studies are to characterize HZE particle radiation induced biological effects and evaluat...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0089-5
更新日期:2007-06-01 00:00:00
abstract::To explore the expression level and the role of peroxisome proliferator-activated receptor gamma (PPAR-γ) in radiation-induced heart injury in a rat model, thirty-two Sprague-Dawley rats were divided into three groups (the control group, the 15-Gy irradiation group and the 18-Gy irradiation group). Experimental animal...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-011-0390-9
更新日期:2012-03-01 00:00:00
abstract::Cl-36 is an important component of nuclear waste. The concentrations of stable chlorine (Cl) in pig and cow tissues were measured to provide information which can be used to parameterize models of (36)Cl transfer into agricultural animals. The concentration of stable Cl in cows' milk was 1.0 +/- 0.2 g L(-1), in cow mu...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0137-9
更新日期:2008-02-01 00:00:00
abstract::In this work, direct DNA damage induced by low-energy electrons (sub-keV) is simulated using a Monte Carlo method. The characteristics of the present simulation are to consider the new mechanism of DNA damage due to dissociative electron attachment (DEA) and to allow determining damage to specific bases (i.e., adenine...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-016-0681-2
更新日期:2017-03-01 00:00:00
abstract::The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three radionuclides to sheep...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050078
更新日期:1998-02-01 00:00:00
abstract::In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for th...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/BF01209747
更新日期:1995-11-01 00:00:00
abstract::With a model system of pBR322 plasmid DNA solution in vitro, the dose effects of radiation-induced single- and double-strand breaks (SSB and DSB) were measured and DSB was distinguished into alpha- and beta-types. Under the condition of low scavenging capacity existing in the irradiated DNA solution, SSB and alpha DSB...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110000054
更新日期:2000-06-01 00:00:00
abstract::Model experiments with two structurally different proteins (alcohol dehydrogenase and salmine) show that glycine, alanine, and tyrosine are by far more frequently involved in photochemically induced cross-link formations with DNA than is cysteine. The yields for cross-link formation of thymidine with salmine (cysteine...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01332171
更新日期:1976-07-30 00:00:00
abstract::Activity catalysing double-strand DNA recombination has been investigated in human tumour cell lines using an in vitro assay in which nuclear extracts from tumour cells are used to catalyse homologous recombination between deletion plasmids. The cell lines investigated showed comparable constitutive levels of recombin...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050056
更新日期:1997-02-01 00:00:00
abstract::The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and i...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0267-3
更新日期:2010-05-01 00:00:00
abstract::The migration of radionuclides from waste repositories to the biosphere potentially leads to a contamination of soil. Due to the importance of food production, the mobilisation and accumulation behaviour of long-lived radionuclides in the soil plays a key role in performance assessment studies. In this paper, the main...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s004110100098
更新日期:2001-06-01 00:00:00
abstract::The objective of the present work is to apply the plasma clearance parameters to strontium, previously determined in our laboratory, to improve the biokinetic and dosimetric models of strontium-90 ((90)Sr) used in radiological protection; and also to apply this data for the estimation of the radiation doses from stron...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0154-8
更新日期:2008-04-01 00:00:00
abstract::Many experimental studies are carried out to compare biological effectiveness of high dose rate (HDR) with that of low dose rate (LDR). The rational for this is the uncertainty regarding the value of the dose rate effectiveness factor (DREF) used in radiological protection. While a LDR is defined as 0.1 mGy/min or low...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00852-z
更新日期:2020-08-01 00:00:00
abstract::Thorough studies of 28 water bodies, predominantly lakes from the younger moraine area of Schleswig-Holstein, Northern Germany but also some peat bog waters in Niedersachsen, Northern Germany and lake Balaton in Hungary, showed the presence of at least six redox systems: NO3-/NO2-; NO3-/NH4+; NO2-/NH4+; So/HS-; So/H2S...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01221229
更新日期:1986-01-01 00:00:00
abstract::Blue (F450) and green (F530) leaf fluorescence were studied together with the red chlorophyll fluorescence (emission maxima F690 and F735) during light-induced chlorophyll fluorescence induction kinetics (Kautsky effect) in predarkened leaves of wheat (Triticum aestivum L.) and soybean (Glycine max L.). The intensity ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01225923
更新日期:1993-01-01 00:00:00
abstract::The macroscopic reaction of the mouse skin was used to derive RBE values for negative pi-Mesons. Hind limbs of mice were irradiated with pions or X-rays. The pions were produced by the 590 MeV accelerator of the Schweizerisches Institut für Nuklearforschung (SIN). Early reaction was assessed over a period of 6--30 day...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01358292
更新日期:1979-08-10 00:00:00
abstract::Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01209769
更新日期:1993-01-01 00:00:00
abstract::Roots of Pisum sativum L. were chronically exposed to 60-Hz vertical electric fields ranging from 150 to 450V/m in an aqueous medium whose conductivity was approximately 0.07 S/m. Control and exposed roots were grown concomitantly in the same tank whose medium was continuously circulated and maintained at 19 degrees C...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323679
更新日期:1983-01-01 00:00:00
abstract::Radiocaesium absorption and retention in reindeer (Rangifer tarandus) calves was compared in groups fed diets containing different proportions of lichen and concentrates, and different chemical forms of radiocaesium ((134)CsCl in solution or fallout from the Chernobyl accident). Daily intakes of fallout radiocaesium w...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-004-0257-4
更新日期:2004-12-01 00:00:00
abstract::Carrier-free 11C-labeled carbon monoxide was produced by proton irradiation of a nitrogen gas flow target via the 14N(p, alpha)11C process followed by on-line reduction of the predominantly formed 11C-carbon dioxide with a yield of 0.4 mCi/muAmin. After appropriate quality control about 2 mCi of carrier-free 11C-carbo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323415
更新日期:1975-12-04 00:00:00
abstract::Non-linear mechanical response of viscoelastic strain responding media to high amplitude stress-strain is examined from a phenomenological point of view and found to lead to results compatible with empirical observations of high intensity ultrasound irradiation of brain, liver, and eye lens tissues. The proposed hyste...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01324230
更新日期:1981-01-01 00:00:00
abstract::It is usually assumed that sparsely ionizing radiation produces randomly distributed DNA breakages. This seems to be supported by the finding that in some DNA fragments single-strand scissions occur uniformly at all nucleotide sites, regardless of sequence. We performed experiments on two DNA fragments of about 300 bp...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01255271
更新日期:1994-01-01 00:00:00
abstract::Dose conversion coefficients (DCCs) for assessment of internal and external radiation exposures to terrestrial and aquatic biota are compiled for 75 radionuclides, for 14 terrestrial and 22 aquatic reference organisms. DCC values for internal exposure are calculated based on a homogeneous distribution of the radionucl...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0159-y
更新日期:2008-04-01 00:00:00
abstract::In head computed tomography, radiation upon the eye lens (as an organ with high radiosensitivity) may cause lenticular opacity and cataracts. Therefore, quantitative dose assessment due to exposure of the eye lens and surrounding tissue is a matter of concern. For this purpose, an accurate eye model with realistic geo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0686-5
更新日期:2017-05-01 00:00:00
abstract::The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0063-2
更新日期:2006-11-01 00:00:00
abstract::Combined action of irradiation (IR), shear stress, and high blood pressure is well recognized to induce damage to vasculature, while data on pathological effects of IR in large peripheral vessels with low blood pressure are scarce. The purpose of the present study was hence to investigate time- and dose-dependent effe...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-013-0492-7
更新日期:2014-03-01 00:00:00