Abstract：
:The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three radionuclides to sheep tissues. The structure of these models is based upon a simplified understanding of the transfer of the macro-elements C, H and S by processes such as respiration and protein synthesis/degradation. A consequence of this approach is that the three models have many common parameters. The models reproduced the general trends of the observations, accounting for 74%, 66%, and 58% of the observed variation in the 14C, 3H and 35S data, respectively, suggesting that they may provide a useful alternative approach to modelling the transfer of these radionuclides. The models presented are limited to the particular experimental situation for which they were developed, and further experimental work would be required to extend them. However, such metabolically based models have great potential: for example, they should be able to account for the influence of dietary intake, physiological status or the form of the radionuclide in the animals diet (e.g. tritiated water or organically bound tritium).
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Crout NM,Mayes RW,Beresford NA,Lamb CS,Howard BJdoi
10.1007/s004110050078subject
Has Abstractpub_date
1998-02-01 00:00:00pages
243-50issue
4eissn
0301-634Xissn
1432-2099journal_volume
36pub_type
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