Abstract:
:To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad whole body gamma irradiation. In the bone marrow a rapid and a slow turnover component of 125-IUdR retention were found. Both components were almost identical for unirradiated and irradiated mice. In the spleen the 125-IUdR retention curves exhibited three components with increasingly prolonged half-times. In the second component the half-time was longer in irradiated than in unirradiated mice. This was dose-dependent. The increased half-time of 125-IUdR retention in irradiated spleens may be caused by direct cellular damage of long-lived cells (lymphocytes, early hematopoietic progenitor cells) or/and by diminished stimulation of proliferation by microenvironmental or long-range factors.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Hübner GE,von Wangenheim KH,Feinendegen LEdoi
10.1007/BF01325468subject
Has Abstractpub_date
1982-01-01 00:00:00pages
195-200issue
3eissn
0301-634Xissn
1432-2099journal_volume
20pub_type
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