Abstract:
:Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) into bovine erythrocytes. Gamma-irradiation of erythrocytes amplified the effects of pCMB, HgCl2 and NEM of inhibition of TEMPOL transport and attenuated them in the case of TEMPO transport. These results suggest that the transport of TEMPOL across the erythrocyte membrane is controlled by both superficially and more deeply located membrane -SH groups while only superficial -SH groups control the transport of TEMPO. The lower extent of inhibition of TEMPO transport indicates a higher contribution of diffusion through the lipid phase to the transport of TEMPO across the erythrocyte membrane as compared with TEMPOL.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Gwoździński K,Bartosz G,Leyko Wdoi
10.1007/BF01323760subject
Has Abstractpub_date
1983-01-01 00:00:00pages
53-9issue
1eissn
0301-634Xissn
1432-2099journal_volume
22pub_type
杂志文章abstract::The effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate (cAMP) in smooth muscle preparations from frog lung was studied. cAMP, given as dibutyryl salt (dib-cAMP) inhibited the radiation induced contractions of the muscle in a manner similar to the action of theophylline. In v...
journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01328977
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
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更新日期:1995-11-01 00:00:00
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323263
更新日期:1978-08-10 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01340573
更新日期:1979-01-01 00:00:00
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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更新日期:2010-05-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323679
更新日期:1983-01-01 00:00:00
abstract::Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acti...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-005-0006-3
更新日期:2005-10-01 00:00:00
abstract::Since the early 1990s, information on radiation-exposed populations other than those exposed from the Chernobyl accident in 1986 has become increasingly available for international scientific research. It is essential to understand how the cohorts of exposed populations have been defined and what mechanisms can be use...
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pub_type: 杂志文章,评审
doi:10.1007/s00411-001-0128-1
更新日期:2002-03-01 00:00:00
abstract::The main target of this work is to examine blood clearance and external exposure for 177Lu-DOTATATE compared with new emerging 177Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq 177Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq 177Lu-PSMA. Dose ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
abstract::The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions dec...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-015-0623-4
更新日期:2016-03-01 00:00:00
abstract::Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose f...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-019-00819-9
更新日期:2020-03-01 00:00:00
abstract::In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00