Effect of thiol reagents and ionizing radiation on the permeability of erythrocyte membrane for spin-labeled non-electrolytes.

Abstract:

:Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) into bovine erythrocytes. Gamma-irradiation of erythrocytes amplified the effects of pCMB, HgCl2 and NEM of inhibition of TEMPOL transport and attenuated them in the case of TEMPO transport. These results suggest that the transport of TEMPOL across the erythrocyte membrane is controlled by both superficially and more deeply located membrane -SH groups while only superficial -SH groups control the transport of TEMPO. The lower extent of inhibition of TEMPO transport indicates a higher contribution of diffusion through the lipid phase to the transport of TEMPO across the erythrocyte membrane as compared with TEMPOL.

journal_name

Radiat Environ Biophys

authors

Gwoździński K,Bartosz G,Leyko W

doi

10.1007/BF01323760

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

53-9

issue

1

eissn

0301-634X

issn

1432-2099

journal_volume

22

pub_type

杂志文章
  • Effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate on smooth muscle preparations.

    abstract::The effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate (cAMP) in smooth muscle preparations from frog lung was studied. cAMP, given as dibutyryl salt (dib-cAMP) inhibited the radiation induced contractions of the muscle in a manner similar to the action of theophylline. In v...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323750

    authors: Schachinger L,Michailov M,Owusa Daaku S,Prechter I,Klöter H,Schippel C

    更新日期:1982-01-01 00:00:00

  • Are mouse lens epithelial cells more sensitive to γ-irradiation than lymphocytes?

    abstract::In this pilot study we compared for the first time the radiation sensitivity of mouse lens epithelial cells (LECs) and mouse lymphocytes. We freshly prepared LECs and lymphocytes and irradiated them with γ-rays ((137)Cs; doses ranging from 0.25 to 2 Gy). DNA damage and repair were evaluated by alkaline comet assay and...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0451-8

    authors: Bannik K,Rössler U,Faus-Kessler T,Gomolka M,Hornhardt S,Dalke C,Klymenko O,Rosemann M,Trott KR,Atkinson M,Kulka U,Graw J

    更新日期:2013-05-01 00:00:00

  • Time- and space-resolved Monte Carlo study of water radiolysis for photon, electron and ion irradiation.

    abstract::Time-dependent yields of the most important products of water radiolysis E(aq)(-), (*)OH, H(*), H(3)O(+), H(2), OH(-) and H(2)O(2) have been calculated for (60)Co-photons, electrons, protons, helium- and carbon-ions incident onto water. G values have been evaluated for the interval from 1 ps to 1 mus after initial ene...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-008-0194-8

    authors: Kreipl MS,Friedland W,Paretzke HG

    更新日期:2009-02-01 00:00:00

  • Radiation-epidemiological studies of thyroid cancer incidence among children and adolescents in the Bryansk oblast of Russia after the Chernobyl accident (1991-2001 follow-up period).

    abstract::In this study, thyroid cancer incidence (follow-up period: 1991-2001) has been analyzed, including persons who were exposed as children at an age between 0 and 17 years and who are living in the Bryansk oblast, the worst contaminated area of Russia after the Chernobyl accident. According to the census of 1989, the pop...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-006-0039-2

    authors: Ivanov VK,Gorski AI,Tsyb AF,Maksioutov MA,Tumanov KA,Vlasov OK

    更新日期:2006-05-01 00:00:00

  • Voxel-based computational models of real human anatomy: a review.

    abstract::Computational models of human anatomy are mathematical representations of human anatomy designed to be used in dosimetry calculations. They have been used in dosimetry calculations for radiography, radiotherapy, nuclear medicine, radiation protection and to investigate the effects of low frequency electromagnetic fiel...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-003-0221-8

    authors: Caon M

    更新日期:2004-02-01 00:00:00

  • Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE).

    abstract::Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-003-0214-7

    authors: Langner I,Blettner M,Gundestrup M,Storm H,Aspholm R,Auvinen A,Pukkala E,Hammer GP,Zeeb H,Hrafnkelsson J,Rafnsson V,Tulinius H,De Angelis G,Verdecchia A,Haldorsen T,Tveten U,Eliasch H,Hammar N,Linnersjö A

    更新日期:2004-02-01 00:00:00

  • Cell-free DNA in the urine of rats exposed to ionizing radiation.

    abstract::Investigation of cell-free DNA (cf-DNA) in body fluids, as a potential biomarker for assessing the effect of ionizing radiation on the organism, is of considerable interest. We investigated changes in the contents of cell-free mitochondrial DNA (cf-mtDNA) and cell-free nuclear DNA (cf-nDNA) in the urine of X-ray-expos...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-015-0599-0

    authors: Abdullaev SA,Minkabirova GM,Bezlepkin VG,Gaziev AI

    更新日期:2015-08-01 00:00:00

  • Radionuclide transfer to marine biota species: review of Russian language studies.

    abstract::An extensive programme of experiments on transfer of radionuclides to aquatic species was conducted in the former USSR starting from the early 1950s. Only a few of these studies were made available in the English language literature or taken into account in international reviews of radionuclide behaviour in marine eco...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-010-0324-y

    authors: Fesenko S,Fesenko E,Titov I,Karpenko E,Sanzharova N,Fonseca AG,Brown J

    更新日期:2010-11-01 00:00:00

  • Studies on mass attenuation coefficient, effective atomic number and electron density of some vitamins.

    abstract::Mass attenuation coefficient, μm, atomic cross-section, σi, electronic cross-section, σe, effective atomic number, Zeff and effective electron density, Nel, were determined experimentally and theoretically for some vitamins (retinol, beta-carotene, thiamine, riboflavin, niacinamide, pantothenic acid, pyridoxine, bioti...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0427-8

    authors: Demir D,Turşucu A,Oznülüer T

    更新日期:2012-11-01 00:00:00

  • Decrease of total activity with time at long distances from a nuclear accident or explosion.

    abstract::Two data groups were analyzed: (1) the exposure rate in the former Czechoslovakia after the Chernobyl accident in 1986, and (2) the decrease of beta activity of an atmospheric fallout sample taken in Bratislava during 24 h on 30 May 1965. Both quantities decreased with the first power of time. This pattern of decrease...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-005-0276-9

    authors: Dolejs J

    更新日期:2005-05-01 00:00:00

  • Neutron scattering and energy deposition spectra.

    abstract::The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01328977

    authors: Coppola M,Booz J

    更新日期:1975-06-18 00:00:00

  • Neutron relative biological effectiveness for solid cancer incidence in the Japanese A-bomb survivors: an analysis considering the degree of independent effects from γ-ray and neutron absorbed doses with hierarchical partitioning.

    abstract::It has generally been assumed that the neutron and γ-ray absorbed doses in the data from the life span study (LSS) of the Japanese A-bomb survivors are too highly correlated for an independent separation of the all solid cancer risks due to neutrons and due to γ-rays. However, with the release of the most recent data ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0445-6

    authors: Walsh L

    更新日期:2013-03-01 00:00:00

  • Low doses of ionizing radiation induce nuclear activity in human tumour cell lines which catalyzes homologous double-strand recombination.

    abstract::Activity catalysing double-strand DNA recombination has been investigated in human tumour cell lines using an in vitro assay in which nuclear extracts from tumour cells are used to catalyse homologous recombination between deletion plasmids. The cell lines investigated showed comparable constitutive levels of recombin...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110050056

    authors: Lehnert S,Chow TY

    更新日期:1997-02-01 00:00:00

  • Radiation-induced carcinogenesis: individual sensitivity and genomic instability.

    abstract::In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for th...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01209747

    authors: Sabatier L,Lebeau J,Dutrillaux B

    更新日期:1995-11-01 00:00:00

  • Microirradiation of cells with energetic heavy ions.

    abstract::The ion microprobe SNAKE at the Munich 14 MV tandem accelerator achieves beam focussing by a superconducting quadrupole doublet and can make use of a broad range of ions and ion energies, from 20 MeV protons to 200 MeV gold ions. Because of these properties, SNAKE is particularly attractive for biological microbeam ex...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-003-0222-7

    authors: Hauptner A,Dietzel S,Drexler GA,Reichart P,Krücken R,Cremer T,Friedl AA,Dollinger G

    更新日期:2004-02-01 00:00:00

  • The theory of tree bole and branch form.

    abstract::Working from the general postulate that natural selection of plant form operates so as to maximize the survival potential of a species, this paper examines the hypothesis that the mechanical support of tree foliage must approach optimality in the use of wood, i.e., that tree stems and branches will have "optimal form"...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323263

    authors: King D,Loucks OL

    更新日期:1978-08-10 00:00:00

  • Distribution of radiation induced lesions in human chromosomes and dose-effect relation analysed with G-banding.

    abstract::Human female lymphocytes were exposed to X-rays in vitro at 7 different doses between 40-280 R. In 830 metaphases chromosome analyses were carried out with either conventional staining or G-banding, respectively. 486 breakpoints are non-randomly distributed between chromosomes and chromosome arms. An excess of lesions...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01340573

    authors: Bauchinger M,Götz G

    更新日期:1979-01-01 00:00:00

  • The influence of the channel size on the reduction of side effects in microchannel proton therapy.

    abstract::The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with d...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-015-0600-y

    authors: Girst S,Greubel C,Reindl J,Siebenwirth C,Zlobinskaya O,Dollinger G,Schmid TE

    更新日期:2015-08-01 00:00:00

  • Calculation on spectrum of direct DNA damage induced by low-energy electrons including dissociative electron attachment.

    abstract::In this work, direct DNA damage induced by low-energy electrons (sub-keV) is simulated using a Monte Carlo method. The characteristics of the present simulation are to consider the new mechanism of DNA damage due to dissociative electron attachment (DEA) and to allow determining damage to specific bases (i.e., adenine...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-016-0681-2

    authors: Liu W,Tan Z,Zhang L,Champion C

    更新日期:2017-03-01 00:00:00

  • Survival of diploid yeast cells to bleomycin in combination with UV-light or hyperthermia.

    abstract::In the present work we have investigated the possible interaction between Bleomycin (B) and UV light or hyperthermia (HT) in the induction of lethal events in diploid yeast populations in the stationary phase of growth. UV and B acting as single agents determine sigmoid survival curves. The combination of UV + B produ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01219348

    authors: Barrios E,Candreva EC,Nunes E

    更新日期:1991-01-01 00:00:00

  • Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles.

    abstract::The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-006-0063-2

    authors: Jianshe Y,Xigang J,Wenjian L,Zhuanzi W,Guangming Z,Jufang W,Bingrong D,Qingxiang G,Linda W

    更新日期:2006-11-01 00:00:00

  • DS02 fluence spectra for neutrons and gamma rays at Hiroshima and Nagasaki with fluence-to-kerma coefficients and transmission factors for sample measurements.

    abstract::Fluence spectra at several ground distances in Hiroshima and Nagasaki are provided along with associated fluence-to-kerma coefficients from the Dosimetry System 2002 (DS02). Also included are transmission factors for calculating expected responses of in situ sample measurements of neutron activation products such as (...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-007-0120-5

    authors: Egbert SD,Kerr GD,Cullings HM

    更新日期:2007-11-01 00:00:00

  • Leukemia incidence among people exposed to chronic radiation from the contaminated Techa River, 1953-2005.

    abstract::Beginning in 1950, people living on the banks of the Techa River received chronic low-dose-rate internal and external radiation exposures as a result of releases from the Mayak nuclear weapons plutonium production facility in the Southern Urals region of the Russian Federation. The Techa River cohort includes about 30...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-009-0257-5

    authors: Krestinina L,Preston DL,Davis FG,Epifanova S,Ostroumova E,Ron E,Akleyev A

    更新日期:2010-05-01 00:00:00

  • On the mechanism of 60-Hz electric field induced effects in Pisum sativum L. roots: vertical field exposures.

    abstract::Roots of Pisum sativum L. were chronically exposed to 60-Hz vertical electric fields ranging from 150 to 450V/m in an aqueous medium whose conductivity was approximately 0.07 S/m. Control and exposed roots were grown concomitantly in the same tank whose medium was continuously circulated and maintained at 19 degrees C...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323679

    authors: Miller MW,Dooley DA,Cox C,Carstensen EL

    更新日期:1983-01-01 00:00:00

  • Interaction of smoking and radon in rats: a biologically based mechanistic model.

    abstract::Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acti...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-005-0006-3

    authors: Heidenreich WF,Morlier JP,Monchaux G

    更新日期:2005-10-01 00:00:00

  • Cause-of-death registers in radiation-contaminated areas of the Russian Federation and Kazakhstan.

    abstract::Since the early 1990s, information on radiation-exposed populations other than those exposed from the Chernobyl accident in 1986 has become increasingly available for international scientific research. It is essential to understand how the cohorts of exposed populations have been defined and what mechanisms can be use...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-001-0128-1

    authors: Winkelmann RA,Tretyakov FD,Startsev NV,Kolyado IB,Gusev BI,Grosche B,Storm HH,Hall P

    更新日期:2002-03-01 00:00:00

  • Blood clearance and occupational exposure for 177Lu-DOTATATE compared to 177Lu-PSMA radionuclide therapy.

    abstract::The main target of this work is to examine blood clearance and external exposure for 177Lu-DOTATATE compared with new emerging 177Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq 177Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq 177Lu-PSMA. Dose ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-017-0721-6

    authors: Abuqbeitah M,Demir M,Uslu-Beşli L,Yeyin N,Sönmezoğlu K

    更新日期:2018-03-01 00:00:00

  • Mechanisms of an increased level of serum iron in gamma-irradiated mice.

    abstract::The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions dec...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-015-0623-4

    authors: Xie LH,Zhang XH,Hu XD,Min XY,Zhou QF,Zhang HQ

    更新日期:2016-03-01 00:00:00

  • Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study.

    abstract::Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose f...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-019-00819-9

    authors: Schöllnberger H,Kaiser JC,Eidemüller M,Zablotska LB

    更新日期:2020-03-01 00:00:00

  • Irradiated stem cells and ageing of the haematopoietic system.

    abstract::In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0401-5

    authors: Vávrová J,Sinkorová Z,Rezáčová M,Tichý A,Filip S,Mokrý J,Lukášová E

    更新日期:2012-05-01 00:00:00