Effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate on smooth muscle preparations.

Abstract:

:The effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate (cAMP) in smooth muscle preparations from frog lung was studied. cAMP, given as dibutyryl salt (dib-cAMP) inhibited the radiation induced contractions of the muscle in a manner similar to the action of theophylline. In vitro irradiation of dib-cAMP resulted in an alteration of the chemical structure of this substance, i.e., formation of monobutyryl-cAMP and further derivatives as well as a decomposition of the purine structure. There was also a loss of the relaxing activity of irradiated cAMP on the muscle tone of frog lung preparations. The physiologically measured inactivation of dib-cAMP was far more pronounced than the chemical alteration. An inhibitory effect of the reaction products is postulated.

journal_name

Radiat Environ Biophys

authors

Schachinger L,Michailov M,Owusa Daaku S,Prechter I,Klöter H,Schippel C

doi

10.1007/BF01323750

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

245-54

issue

4

eissn

0301-634X

issn

1432-2099

journal_volume

20

pub_type

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