Abstract：
:The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with doses larger than the tumor dose, while the tumor gets homogeneously irradiated. The aim of this study was to evaluate the effect of increasing channel width on potential side effects in the normal tissue. A rectangular 180 × 180 µm(2) and two Gaussian-type dose distributions of σ = 260 µm and σ = 520 µm with an interchannel distance of 1.8 mm have been applied by 20-MeV protons to a 3D human skin model in order to simulate the widened channels and to compare the irradiation effects at different endpoints to those of a homogeneous proton irradiation. The number of protons applied was kept constant at all irradiation modes resulting in the same average dose of 2 Gy. All kinds of proton microchannel irradiation lead to higher cell viability and produce significantly less genetic damage than homogeneous proton irradiation, but the reduction is lower for the wider channel sizes. Our findings point toward the application of microchannel irradiation for clinical proton or heavy ion therapy to further reduce damage of normal tissues while maintaining tumor control via a homogeneous dose distribution inside the tumor.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Girst S,Greubel C,Reindl J,Siebenwirth C,Zlobinskaya O,Dollinger G,Schmid TEdoi
10.1007/s00411-015-0600-ysubject
Has Abstractpub_date
2015-08-01 00:00:00pages
335-42issue
3eissn
0301-634Xissn
1432-2099journal_volume
54pub_type
杂志文章abstract：:The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...
journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/BF01328977
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01229821
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323421
更新日期：1975-12-04 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Radiation and environmental biophysics
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doi：10.1007/BF01221972
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
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