Abstract：
:With a model system of pBR322 plasmid DNA solution in vitro, the dose effects of radiation-induced single- and double-strand breaks (SSB and DSB) were measured and DSB was distinguished into alpha- and beta-types. Under the condition of low scavenging capacity existing in the irradiated DNA solution, SSB and alpha DSB were mainly induced by hydroxyl radicals (.OH). Moreover, a certain relationship was obtained between the SSB and alpha DSB yields and the DNA concentration. It was found that when the DNA solution was irradiated in the presence of 2.5 mmol dm-3 mannitol, the reciprocals of G(SSB) and G(alpha DSB), respectively, were linearly related to the reciprocal of the DNA concentration, i.e. the competition reactions of DNA and mannitol for .OH radicals can be described by second-order kinetics. The rate coefficients and the efficiencies of the .OH radical inducing SSB were deduced. Also, the reaction rate coefficients and the efficiencies for the induction of alpha DSB from SSB by the .OH radical transfer mechanism, were first derived from the competition kinetics.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Shao C,Yu Z,Saito Mdoi
10.1007/s004110000054keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
121-4issue
2eissn
0301-634Xissn
1432-2099journal_volume
39pub_type
杂志文章abstract：:The Auger electron emitter 123I was examined in the form of 4-[123I]iodoantipyrine and as [123I]NaI for its effectiveness in killing cells of different sensitivity to photon irradiation. Micronucleus assays showed that 4-[123I]iodoantipyrine is 2-3 times more effective in cell inactivation than [123I]NaI. This can be ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110000083
更新日期：2001-03-01 00:00:00
abstract：:A Monte Carlo model is presented to study details of the energy deposition inside tracks of heavy charged particles in water vapor. The input data for most of the calculations based on the binary encounter approximation are double-differential cross sections for electron emission after heavy-ion impact. The paths of t...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/BF01219334
更新日期：1994-01-01 00:00:00
abstract：:To explore the expression level and the role of peroxisome proliferator-activated receptor gamma (PPAR-γ) in radiation-induced heart injury in a rat model, thirty-two Sprague-Dawley rats were divided into three groups (the control group, the 15-Gy irradiation group and the 18-Gy irradiation group). Experimental animal...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-011-0390-9
更新日期：2012-03-01 00:00:00
abstract：:The rare earth radionuclides 177 Lu and 153Sm were administered as single i.p. injections in NMRI mice. Lu was deposited principally (up to 60%) in the skeleton if the quantity of stable carrier was low. Increase of stable carrier enhanced deposition in the reticulo-endothelial system. Sm was preferentially deposited ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01324368
更新日期：1980-01-01 00:00:00
abstract：:Ehrlich ascites tumour cells were irradiated with negative pions at different positions in the plateau and the peak of the depth absorbed dose curve. Dose-survival curves for immediate testing of the viability of the cells are given and are compared with other types of radiations in use for therapy. From the data obta...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01358286
更新日期：1979-08-10 00:00:00
abstract：:The main aim of this study was to investigate the dosimetric characteristics of the INTRABEAM ® system in the presence of air gaps between the surface of applicators (APs) and tumor bed. Additionally, the effect of tissue heterogeneities was another focus. Investigating the dosimetric characteristics of the INTRABEAM®...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00835-0
更新日期：2020-05-01 00:00:00
abstract：:At five stages of gestation, mice were exposed dorsally to ultrasonic irradiation at 1 W/cm2 (spatial and temporal average), 2 MHz, and 34 and 37 degrees C (temperature at beginning of exposure). The results indicated that ultrasonic exposure up to at least 100 s is not hazardous to a pregnant mouse or its offspring i...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323651
更新日期：1980-01-01 00:00:00
abstract：:The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they we...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050149
更新日期：1999-07-01 00:00:00
abstract：:The sulphur-containing radioprotectors mercaptoethylamine (MEA), aminoethylisothiourea (AET), 2- aminothiazoline , 4-oxo-2- aminothiazoline , and S-S-3- oxapentane -1,5- diisothiourea , and the radioprotective biogenic amines serotonin, histamine, and dopamine, caused the elevation of cAMP content and intensified the ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01213732
更新日期：1984-01-01 00:00:00
abstract：:The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211238
更新日期：1996-02-01 00:00:00
abstract：:The biological phenomena observed at low doses of ionizing radiation (adaptive response, bystander effects, genomic instability, etc.) are still not well understood. While at high irradiation doses, cellular death may be directly linked to DNA damage, at low doses, other cellular structures may be involved in what are...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-015-0622-5
更新日期：2016-03-01 00:00:00
abstract：:Growing hair follicles with their rapid cell proliferation would be expected to be sensitive organs to cytotoxic agents such as radiation. Various abnormalities in the hair and hair follicles have been reported in the past. Changes in the number of cells in the newly forming hair cortex have been shown in the mouse to...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF02434035
更新日期：1996-05-01 00:00:00
abstract：:Non-linear mechanical response of viscoelastic strain responding media to high amplitude stress-strain is examined from a phenomenological point of view and found to lead to results compatible with empirical observations of high intensity ultrasound irradiation of brain, liver, and eye lens tissues. The proposed hyste...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01324230
更新日期：1981-01-01 00:00:00
abstract：:Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...
journal_title：Radiation and environmental biophysics
pub_type： 临床试验,杂志文章
doi：10.1007/s00411-018-0768-z
更新日期：2019-03-01 00:00:00
abstract：:The rate constants for the photodynamic inactivation of hen egg-white lysozyme at different temperatures were studied. Arrhenius plots of the methylene blue sensitized photo-inactivation of lysozyme gave an experimental activation energy of 7.5 kcal/mol. The rate constants for the photodynamic inactivation of lysozyme...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01326898
更新日期：1979-02-23 00:00:00
abstract：:Blue (F450) and green (F530) leaf fluorescence were studied together with the red chlorophyll fluorescence (emission maxima F690 and F735) during light-induced chlorophyll fluorescence induction kinetics (Kautsky effect) in predarkened leaves of wheat (Triticum aestivum L.) and soybean (Glycine max L.). The intensity ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01225923
更新日期：1993-01-01 00:00:00
abstract：:Computational models of human anatomy are mathematical representations of human anatomy designed to be used in dosimetry calculations. They have been used in dosimetry calculations for radiography, radiotherapy, nuclear medicine, radiation protection and to investigate the effects of low frequency electromagnetic fiel...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/s00411-003-0221-8
更新日期：2004-02-01 00:00:00
abstract：:Several proteins are known to form foci at DNA sites damaged by ionizing radiation. We study DNA damage response by immunofluorescence microscopy after microirradiation of cells with energetic ions. By using microirradiation, it is possible to irradiate different regions on a single dish at different time-points and t...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-008-0181-0
更新日期：2008-11-01 00:00:00
abstract：:The TEL1 gene from Saccharomyces cerevisiae has been shown to be the closest sequence homologue to ATM, the gene mutated in ataxia-telangiectasia (A-T) patients. Functional homology shared between the ATM and Tell proteins has recently been demonstrated based on heterologous expression of the TEL1 gene in human cells ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-001-0125-4
更新日期：2001-12-01 00:00:00
abstract：:The antioxidant properties of hydroxycinnamic acid derivatives (HCA) were studied by laser flash photolysis. The transient species with maximum absorption at 360 nm were assigned to the phenoxyl radical of HCA. The SO (4) (.-) induced oxidation of HCA was also investigated. It was shown that the interaction of SO (4) ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0041-8
更新日期：2006-05-01 00:00:00
abstract：:Osteosarcoma is the most frequent secondary malignancy following radiotherapy of patients with bilateral retinoblastoma. This suggests that the Rb1 tumour suppressor gene might confer genetic susceptibility towards radiation-induced osteosarcoma. To define the contribution of the Rb1 pathway in the multistep process o...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-010-0339-4
更新日期：2011-03-01 00:00:00
abstract：:In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-012-0401-5
更新日期：2012-05-01 00:00:00
abstract：:Age-specific and cumulative mortality rates are presented for different cancer sites from 1970 until 1988 for the 11 individual federal states of West Germany (FRG). Sex- and age-specific evaluations are performed and temporal and regional trends in mortality from different cancer sites are revealed. In the FRG there ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01212802
更新日期：1993-01-01 00:00:00
abstract：:Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,meta分析
doi：10.1007/s00411-018-0770-5
更新日期：2019-03-01 00:00:00
abstract：:The main target of this work is to examine blood clearance and external exposure for 177Lu-DOTATATE compared with new emerging 177Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq 177Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq 177Lu-PSMA. Dose ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-017-0721-6
更新日期：2018-03-01 00:00:00
abstract：:In this study, temporal variations of indoor radon concentrations in Bulgaria were investigated. The radon concentrations were measured by nuclear track detectors as part of the Bulgarian National Survey, performed in the dwellings of 28 regional districts. The detectors were exposed through a year in two consecutive ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-019-00789-y
更新日期：2019-08-01 00:00:00
abstract：:The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with d...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-015-0600-y
更新日期：2015-08-01 00:00:00
abstract：:The migration of radionuclides from waste repositories to the biosphere potentially leads to a contamination of soil. Due to the importance of food production, the mobilisation and accumulation behaviour of long-lived radionuclides in the soil plays a key role in performance assessment studies. In this paper, the main...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/s004110100098
更新日期：2001-06-01 00:00:00
abstract：:Activity concentrations of the selected radionuclides (40)K, (226)Ra and (232)Th were measured in surface soil samples collected from 38 cities in the southwest region of Nigeria by means of gamma spectroscopy with a high-purity germanium detector. Measured activity concentration values of (40)K varied from 34.9 +/- 4...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-009-0225-0
更新日期：2009-08-01 00:00:00
abstract：:To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01325468
更新日期：1982-01-01 00:00:00
