Repair of cellular radiation damage in space under microgravity conditions.

Abstract:

:The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they were incubated at the permissive temperature to allow repair. Before re-entry they were again cooled down and kept at a low temperature until final analysis. The experiment, which was flown on the shuttle Atlantis on flight STS-76 (SMM-03), showed that repair of pre-formed DNA double-strand breaks in yeast is not impaired by microgravity.

journal_name

Radiat Environ Biophys

authors

Pross HD,Kiefer J

doi

10.1007/s004110050149

keywords:

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

133-8

issue

2

eissn

0301-634X

issn

1432-2099

journal_volume

38

pub_type

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