Abstract:
:Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Dalke C,Neff F,Bains SK,Bright S,Lord D,Reitmeir P,Rößler U,Samaga D,Unger K,Braselmann H,Wagner F,Greiter M,Gomolka M,Hornhardt S,Kunze S,Kempf SJ,Garrett L,Hölter SM,Wurst W,Rosemann M,Azimzadeh O,Tapio S,Audoi
10.1007/s00411-017-0728-zsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
99-113issue
2eissn
0301-634Xissn
1432-2099pii
10.1007/s00411-017-0728-zjournal_volume
57pub_type
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