Biological impact of low dose-rate simulated solar particle event radiation in vivo.

Abstract:

:C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL). Peripheral blood was harvested from animals from 1 to 12 days after total body irradiation (TBI) to quantify the level of circulating reticulocytes (RET) and micronucleated reticulocytes (MN-RET) as an early indicator of radiation-induced genotoxicity. Bone marrow lymphocytes and hippocampal tissues from each animal were collected at 12 days and up to two months, to evaluate dose-dependent late effects after sSPE exposure. Early hematopoietic changes show that the % RET was reduced up to 3 days in response to radiation exposure but recovered at 12 days postirradiation. The % MN-RET in peripheral blood was temporally regulated and dependant on the total accumulated dose. Total chromosome aberrations in lymphocytes increased linearly with dose within a week after radiation and remained significantly higher than the control values at 4 weeks after exposure. The level of aberrations in the irradiated animals returned to control levels by 8 weeks postirradiation. Measurements of chromosome 2 and 8 specific aberrations indicate that, consistent with conventional giemsa-staining methods, the level of aberrations is also not significantly higher than in control animals at 8 weeks postirradiation. The hippocampus was surveyed for differential transcriptional regulation of genes known to be associated with neurogenesis. Our results showed differential expression of neurotrophin and their associated receptor genes within 1 week after sSPE exposure. Progressive changes in the profile of expressed genes known to be involved in neurogenic signaling pathways were dependent on the sSPE dose. Our results to date suggest that radiation-induced changes in the hematopoietic system, i.e., chromosome aberrations in lymphocytes, are transient and do not persist past 4 weeks after radiation. On the other hand, alteration in the profile of genes known to be involved in neurotrophic functions in the hippocampal tissue appears to persist for up to 8 weeks after radiation exposure. Such temporal changes confirm that, although cytogenetic changes after a single dose of low-dose and low-dose-rate protons appear to be transient, the impact of this exposure is sufficient to lead to persistent dynamic changes in neuronal tissues long after the initial radiation exposure.

journal_name

Radiat Environ Biophys

authors

Chang PY,Doppalapudi R,Bakke J,Wang A,Menda S,Davis Z

doi

10.1007/s00411-010-0291-3

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

379-88

issue

3

eissn

0301-634X

issn

1432-2099

journal_volume

49

pub_type

杂志文章
  • Statistical methods in regression and calibration analysis of chromosome aberration data.

    abstract::The method of iteratively reweighted least squares for the regression analysis of Poisson distributed chromosome aberration data is reviewed in the context of other fit procedures used in the cytogenetic literature. As an application of the resulting regression curves methods for calculating confidence intervals on do...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323412

    authors: Merkle W

    更新日期:1983-01-01 00:00:00

  • Are pre- or postnatal diagnostic X-rays a risk factor for childhood cancer? A systematic review.

    abstract::The risk of cancer after diagnostic X-rays received as fetus or during early childhood has been investigated in many studies. The results of recent epidemiological studies are summarized in a present systematic review. The strategies for literature search, inclusion criteria, and items for study quality assessment wer...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-008-0171-2

    authors: Schulze-Rath R,Hammer GP,Blettner M

    更新日期:2008-07-01 00:00:00

  • Neutron relative biological effectiveness for solid cancer incidence in the Japanese A-bomb survivors: an analysis considering the degree of independent effects from γ-ray and neutron absorbed doses with hierarchical partitioning.

    abstract::It has generally been assumed that the neutron and γ-ray absorbed doses in the data from the life span study (LSS) of the Japanese A-bomb survivors are too highly correlated for an independent separation of the all solid cancer risks due to neutrons and due to γ-rays. However, with the release of the most recent data ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0445-6

    authors: Walsh L

    更新日期:2013-03-01 00:00:00

  • Damage at two levels of DNA folding measured by fluorescent halo technique in X-irradiated L5178Y-R and L5178Y-S cells. I. Initial lesions.

    abstract::We examined, by the fluorescent halo assay, alterations in the nucleoid structure (structure formed from cells under mild lysis conditions: in non-ionic detergent Triton X-100, 0.0005% and 1.5 mol/l NaCl) of L5178Y (LY) cell sublines which had been untreated, treated with reducing/chelating agents (beta-mercaptoethano...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01210211

    authors: Kapiszewska M,Szumiel I,Lange CS

    更新日期:1992-01-01 00:00:00

  • [Separation of the effects of transmutation and radiation after incorporation of radionuclides into DNA (author's transl)].

    abstract::Among the various methods for studying the relative effects of transmutation and radiation of incorporated nuclides, simulation of beta radiation by external gamma exposure is of practical importance. Self-irradiation and mutual irradiation of the labeled cells cannot be neglected in any case. Furthermore, additional ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01326755

    authors: Hamann HJ,Irskens M

    更新日期:1975-01-01 00:00:00

  • NOREC, a Monte Carlo code for simulating electron tracks in liquid water.

    abstract::The work reported here was originally motivated by a discussion of Monte Carlo computer codes for electron transport in water given in Report No. 130 by the National Council on Radiation Protection and Measurements (NCRP). It was pointed out (correctly) that a published depth-dose distribution calculated by the Oak Ri...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-003-0201-z

    authors: Semenenko VA,Turner JE,Borak TB

    更新日期:2003-10-01 00:00:00

  • Radiation-induced carcinogenesis: individual sensitivity and genomic instability.

    abstract::In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for th...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01209747

    authors: Sabatier L,Lebeau J,Dutrillaux B

    更新日期:1995-11-01 00:00:00

  • Confocal microscopy for modeling electron microbeam irradiation of skin.

    abstract::For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tiss...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-011-0371-z

    authors: Miller JH,Chrisler WB,Wang X,Sowa MB

    更新日期:2011-08-01 00:00:00

  • Induction and prevention of carcinogenesis in rat skin exposed to space radiation.

    abstract::Quantitative cancer incidence data exist for various laboratory animal models, but little of this information is usable for estimating human risks, primarily because of uncertainties about possible mechanistic differences among species. Acceptance and utilization of animal data for human risk assessment will require a...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-007-0106-3

    authors: Burns FJ,Tang MS,Frenkel K,Nádas A,Wu F,Uddin A,Zhang R

    更新日期:2007-06-01 00:00:00

  • Mechanisms of an increased level of serum iron in gamma-irradiated mice.

    abstract::The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions dec...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-015-0623-4

    authors: Xie LH,Zhang XH,Hu XD,Min XY,Zhou QF,Zhang HQ

    更新日期:2016-03-01 00:00:00

  • Nuclear energy: health impact of carbon-14.

    abstract::Estimates are presented on the carbon-14 generation rates in several reactor types and in peaceful nuclear explosions. If the carbon-14 generated in light water reactors is released, the population radiation dose rate it causes initially will be comparable to that resulting from the krypton-85 and tritium generated in...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01331176

    authors: Pohl RO

    更新日期:1976-12-23 00:00:00

  • Residual radiation effect in the murine hematopoietic stem cell compartment.

    abstract::Stem cells surviving radiation injury may carry defects which contribute to long-term effects. The ratio of 125-iododeoxyuridine (IUdR) uptake into spleens of lethally irradiated recipient mice between day 3 and day 5 after cell transfusion revealed reduced proliferative ability (PF) of spleen seeding cells in paralle...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01211733

    authors: von Wangenheim KH,Peterson HP,Feinendegen LE

    更新日期:1986-01-01 00:00:00

  • Development and testing of a revised dynamic model of radiocaesium transfer to sheep tissues.

    abstract::The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01211238

    authors: Crout NM,Beresford NA,Howard BJ,Mayes RW,Assimakopoulos PA,Vandecasteele CM

    更新日期:1996-02-01 00:00:00

  • Analysis of chromosome aberrations in human peripheral lymphocytes induced by in vitro alpha-particle irradiation.

    abstract::Irradiation of human lymphocytes by alpha-particles under different conditions has been seen to be substantially more effective in the induction of dicentric chromosomes than irradiation by gamma-rays. However, the relative biological effectiveness (RBE) determined in these studies differed by a factor of more than 10...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110050028

    authors: Schmid E,Hieber L,Heinzmann U,Roos H,Kellerer AM

    更新日期:1996-08-01 00:00:00

  • Radionuclide transfer to marine biota species: review of Russian language studies.

    abstract::An extensive programme of experiments on transfer of radionuclides to aquatic species was conducted in the former USSR starting from the early 1950s. Only a few of these studies were made available in the English language literature or taken into account in international reviews of radionuclide behaviour in marine eco...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-010-0324-y

    authors: Fesenko S,Fesenko E,Titov I,Karpenko E,Sanzharova N,Fonseca AG,Brown J

    更新日期:2010-11-01 00:00:00

  • Potential survival of the lichen Caloplaca flavovirescens under high helium-beam doses.

    abstract::Testing the limits of survivability in space is the primary focus in astrobiological research. Although a number of previous studies have examined terrestrial life survival in an extraterrestrial environment, only a few have investigated how life systems respond to high doses of alpha cosmic ray, the main component of...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-019-00803-3

    authors: Miki K,Kawashima S,Takahashi Y,Yonemura S

    更新日期:2019-08-01 00:00:00

  • Neutron scattering and energy deposition spectra.

    abstract::The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01328977

    authors: Coppola M,Booz J

    更新日期:1975-06-18 00:00:00

  • Comparative study of G2 delay and survival after 241 Americium-alpha and 60cobalt-gamma irradiation.

    abstract::Survival and G2 dalay following exposure to either 60Cobalt-gamma-rays or 241Americium-alpha-particles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effec...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01325466

    authors: Lücke-Huhle C,Comper W,Hieber L,Pech M

    更新日期:1982-01-01 00:00:00

  • Measurement of resuspended aerosol in the Chernobyl area. Part III. Size distribution and dry deposition velocity of radioactive particles during anthropogenic enhanced resuspension.

    abstract::During anthropogenic activities, such as agricultural soil management and traffic on unpaved roads, size distribution measurements were performed of atmospheric particulate radionuclides at a site in the Chernobyl 30-km exclusion zone. Analysis of cascade impactor measurements showed an increase of the total atmospher...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110050118

    authors: Garger EK,Paretzke HG,Tschiersch J

    更新日期:1998-10-01 00:00:00

  • Studies on incorporated short-lived beta-emitters with regard to the induction of late effects.

    abstract::The rare earth radionuclides 177 Lu and 153Sm were administered as single i.p. injections in NMRI mice. Lu was deposited principally (up to 60%) in the skeleton if the quantity of stable carrier was low. Increase of stable carrier enhanced deposition in the reticulo-endothelial system. Sm was preferentially deposited ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01324368

    authors: Müller WA,Scháffer EH,Linzner U

    更新日期:1980-01-01 00:00:00

  • Effect of negative pions, relative to 140 kV -- 29 MeV photons and 20 MeV electrons, on proliferation of Ehrlich ascites carcinoma cells.

    abstract::The effect of negative pions (peak and plateau), photons (140 kV and 29 MeV), and 20 MeV electrons on the proliferative capacity of Ehrlich ascites carcinoma cells was investigated. Proliferative survival curves plotted for the modalities employed are presented. Under the experimental conditions used, the peak pions w...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01358287

    authors: Rao KR,Blattmann H,Cordt I,Fritz-Niggli H

    更新日期:1979-08-10 00:00:00

  • Impact assessment of ionizing radiation on human and non-human biota from the vicinity of a near-surface radioactive waste repository.

    abstract::This work describes the radiological assessment of the near-surface Maisiagala radioactive waste repository (Lithuania) over the period 2005-2012, with focus on water pathways and special emphasis on tritium. The study includes an assessment of the effect of post-closure upgrading, the durability of which is greater t...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-013-0459-8

    authors: Nedveckaite T,Gudelis A,Vives i Batlle J

    更新日期:2013-05-01 00:00:00

  • Leukemia incidence among people exposed to chronic radiation from the contaminated Techa River, 1953-2005.

    abstract::Beginning in 1950, people living on the banks of the Techa River received chronic low-dose-rate internal and external radiation exposures as a result of releases from the Mayak nuclear weapons plutonium production facility in the Southern Urals region of the Russian Federation. The Techa River cohort includes about 30...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-009-0257-5

    authors: Krestinina L,Preston DL,Davis FG,Epifanova S,Ostroumova E,Ron E,Akleyev A

    更新日期:2010-05-01 00:00:00

  • Occupational exposure to electromagnetic fields and adult leukaemia: a review of the epidemiological evidence.

    abstract::The relationship between occupational exposure to extremely low-frequency electromagnetic fields and adult leukaemia has been studied extensively during the last decade. The first studies were based on crude exposure assessments, estimated through job titles, with no or only limited control confounding factors. The re...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s004110050036

    authors: Feychting M

    更新日期:1996-11-01 00:00:00

  • Enhanced proliferation of cells from human tissue explants following irradiation in the presence of environmental carcinogens.

    abstract::A method which allows growth of normal human tissue to be studied in vitro is used to investigate possible interactive effects of radiation and environmentally important carcinogens on oesophageal and urothelial cell growth. Carcinogens chosen were selected for their known or suspected effect on the oesophageal mucosa...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01211257

    authors: Mothersill C,Cusack A,Seymour CB

    更新日期:1989-01-01 00:00:00

  • Are cancer risks associated with exposures to ionising radiation from internal emitters greater than those in the Japanese A-bomb survivors?

    abstract::After ingestion or inhalation of radionuclides, internal organs of the human body will be exposed to ionising radiation. Current risk estimates of radiation-associated cancer from internal emitters are largely based on extrapolation of risk from high-dose externally exposed groups. Concerns have been expressed that ex...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00411-007-0122-3

    authors: Little MP,Hall P,Charles MW

    更新日期:2007-11-01 00:00:00

  • The IRI-DICE hypothesis: ionizing radiation-induced DSBs may have a functional role for non-deterministic responses at low doses.

    abstract::Low-dose ionizing radiation (IR) responses remain an unresolved issue in radiation biology and risk assessment. Accurate knowledge of low-dose responses is important for estimation of normal tissue risk in cancer radiotherapy or health risks from occupational or hazard exposure. Cellular responses to low-dose IR appea...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-020-00854-x

    authors: Langen B,Helou K,Forssell-Aronsson E

    更新日期:2020-08-01 00:00:00

  • Variability of water content and of depth profiles of global fallout 137Cs in grassland soils and the resulting external gamma-dose rates.

    abstract::137Cs from global fallout of nuclear weapon testings in the 1950s and 1960s was determined in successive layers (0-30 cm) of eight undisturbed grassland soils in Bavaria, Germany. The maximum activity concentration was found in soil layers between 4 and 15 cm below the surface. Using the vertical distribution of the c...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110050088

    authors: Schimmack W,Steindl H,Bunzl K

    更新日期:1998-04-01 00:00:00

  • Survival of diploid yeast cells to bleomycin in combination with UV-light or hyperthermia.

    abstract::In the present work we have investigated the possible interaction between Bleomycin (B) and UV light or hyperthermia (HT) in the induction of lethal events in diploid yeast populations in the stationary phase of growth. UV and B acting as single agents determine sigmoid survival curves. The combination of UV + B produ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01219348

    authors: Barrios E,Candreva EC,Nunes E

    更新日期:1991-01-01 00:00:00

  • Cellular and tissue responses to heavy ions: basic considerations.

    abstract::Responses of the S/S variant of the L5178Y murine leukemic lymphoblast, the photoreceptor cell of the rabbit retina and the lenticular epithelium of the rabbit to heavy ions (20Ne, 28Si, 40Ar and 56Fe) are described and discussed primarily from the standpoint of the need for a comprehensive theory of cellular radiosen...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01209679

    authors: Lett JT,Cox AB,Bergtold DS

    更新日期:1986-01-01 00:00:00