Abstract:
:Stem cells surviving radiation injury may carry defects which contribute to long-term effects. The ratio of 125-iododeoxyuridine (IUdR) uptake into spleens of lethally irradiated recipient mice between day 3 and day 5 after cell transfusion revealed reduced proliferative ability (PF) of spleen seeding cells in parallel with reduced CFU-S content of donors throughout the study period of one year after 5 Gy gamma irradiation. Additional data aided in evaluating possible mechanisms of PF reduction. Within the range of the graft sizes used, PF was independent of the numbers of cells or CFU-S transfused. Radiation-induced increase in loss of label between days 3 and 5 and prolonged doubling time of proliferating cells indicated enhancement of cell maturation and increase in mitotic cycle time. Increased IUdR uptake per transfused CFU-S suggested extra divisions of transit cells due to insufficiency in the stem cell compartment. It is concluded that persisting defects in surviving stem cells interfere in a complex way with cell proliferation in the hemopoietic system.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
von Wangenheim KH,Peterson HP,Feinendegen LEdoi
10.1007/BF01211733subject
Has Abstractpub_date
1986-01-01 00:00:00pages
93-106issue
2eissn
0301-634Xissn
1432-2099journal_volume
25pub_type
杂志文章abstract::Radiation-related risks of cancer can be transported from one population to another population at risk, for the purpose of calculating lifetime risks from radiation exposure. Transfer via excess relative risks (ERR) or excess absolute risks (EAR) or a mixture of both (i.e., from the life span study (LSS) of Japanese a...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-012-0441-x
更新日期:2013-03-01 00:00:00
abstract::To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01325468
更新日期:1982-01-01 00:00:00
abstract::Blue (F450) and green (F530) leaf fluorescence were studied together with the red chlorophyll fluorescence (emission maxima F690 and F735) during light-induced chlorophyll fluorescence induction kinetics (Kautsky effect) in predarkened leaves of wheat (Triticum aestivum L.) and soybean (Glycine max L.). The intensity ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01225923
更新日期:1993-01-01 00:00:00
abstract::Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01209769
更新日期:1993-01-01 00:00:00
abstract::The ion microprobe SNAKE at the Munich 14 MV tandem accelerator achieves beam focussing by a superconducting quadrupole doublet and can make use of a broad range of ions and ion energies, from 20 MeV protons to 200 MeV gold ions. Because of these properties, SNAKE is particularly attractive for biological microbeam ex...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-003-0222-7
更新日期:2004-02-01 00:00:00
abstract::Microcalorimetric experiments on growth and maintenance metabolism of Saccharomyces strains ranging from haploid to hexaploid are described. During growth, the mean dry weight, the mean volume and the maximum heat flux of the cells are nearly linear functions of ploidy. These parameters are correlated with the cell co...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323624
更新日期:1976-03-30 00:00:00
abstract::Combined action of irradiation (IR), shear stress, and high blood pressure is well recognized to induce damage to vasculature, while data on pathological effects of IR in large peripheral vessels with low blood pressure are scarce. The purpose of the present study was hence to investigate time- and dose-dependent effe...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-013-0492-7
更新日期:2014-03-01 00:00:00
abstract::The evolution of the proflavine triplet state population with the extent of aggregation is examines, by ESRmeasurements, as a function of organic solvents and mineral salts, well known for their ability to influence the aggregation process. The intensity of the triplet state population has also been investigated as a ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323421
更新日期:1975-12-04 00:00:00
abstract::An inter-comparison of five models designed to predict the effect of ionizing radiation on populations of non-human wildlife, performed under the IAEA EMRAS II programme, is presented and discussed. A benchmark scenario 'Population response to chronic irradiation' was developed in which stable generic populations of m...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-012-0430-0
更新日期:2012-11-01 00:00:00
abstract::The radiation-induced process of strand breaks on pBR322 plasmid DNA in aqueous solution for different energy electrons was studied by Monte Carlo simulation. Assumptions of induction mechanisms of single- and double-strand breaks (SSBs and DSBs) used in the simulation are that SSB is induced by OH or H reaction with ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-002-0161-8
更新日期:2002-09-01 00:00:00
abstract::Ehrlich ascites tumour cells were irradiated with negative pions at different positions in the plateau and the peak of the depth absorbed dose curve. Dose-survival curves for immediate testing of the viability of the cells are given and are compared with other types of radiations in use for therapy. From the data obta...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01358286
更新日期:1979-08-10 00:00:00
abstract::The fluorescent intercalation complex of ethidium bromide with DNA was used as a probe to demonstrate damage in the base-pair region of DNA, due to the action of superoxide radicals. The O.2- radical itself, generated by gamma-radiolysis of oxygenated aqueous Na-formate solutions, is rather ineffective with respect to...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326732
更新日期:1984-01-01 00:00:00
abstract::In mice, persisting radiation-induced growth retardation of hematopoietic tissue suggested that at least part of the surviving stem cells are genetically injured. Additional mitotic stress some time after the radiation insult might remove injured stem cells, thus improving the overall recovery of the irradiated bone m...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211410
更新日期:1987-01-01 00:00:00
abstract::Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,meta分析
doi:10.1007/s00411-018-0770-5
更新日期:2019-03-01 00:00:00
abstract::In this pilot study we compared for the first time the radiation sensitivity of mouse lens epithelial cells (LECs) and mouse lymphocytes. We freshly prepared LECs and lymphocytes and irradiated them with γ-rays ((137)Cs; doses ranging from 0.25 to 2 Gy). DNA damage and repair were evaluated by alkaline comet assay and...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-012-0451-8
更新日期:2013-05-01 00:00:00
abstract::An extensive programme of experiments on transfer of radionuclides to aquatic species was conducted in the former USSR starting from the early 1950s. Only a few of these studies were made available in the English language literature or taken into account in international reviews of radionuclide behaviour in marine eco...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-010-0324-y
更新日期:2010-11-01 00:00:00
abstract::125I incorporated in DNA is known to be exceptionally toxic. Values of D0 range from about 40 to about 90 decays for survival of mammalian cells. The effectiveness of 125I in DNA with respect to the induction of breaks of the DNA strands, however, appears to be comparatively low. The numbers of strand breaks per energ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01213705
更新日期:1987-01-01 00:00:00
abstract::The majority of the public in industrial countries believes that pollution and low doses of radiation are threats to good health. As a matter of fact, when these putative risks are compared to those originating from lifestyle, they appear very small. In particular, the risks associated with low doses of irradiation, e...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/pl00007682
更新日期:2000-03-01 00:00:00
abstract::Radiological impact assessment for flora and fauna requires adequate dosimetric data. Due to the variability of habitats, shapes, and masses of the non-human biota, assessment of doses is a challenging task. External and internal dose conversion coefficients for photons and electrons have been systematically calculate...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0061-4
更新日期:2006-09-01 00:00:00
abstract::The root apex cells of Pisum sativum were irradiated in an U-240 isochronous cyclotron at the Institute for Nuclear Research of the Ukrainian National Academy of Sciences, Kyiv. Several types of micronuclei, differing in structural peculiarities, were observed in the 84 h following exposure to beams of accelerated 1H,...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01275215
更新日期:1995-06-01 00:00:00
abstract::In this study, temporal variations of indoor radon concentrations in Bulgaria were investigated. The radon concentrations were measured by nuclear track detectors as part of the Bulgarian National Survey, performed in the dwellings of 28 regional districts. The detectors were exposed through a year in two consecutive ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-019-00789-y
更新日期:2019-08-01 00:00:00
abstract::In this study, thyroid cancer incidence (follow-up period: 1991-2001) has been analyzed, including persons who were exposed as children at an age between 0 and 17 years and who are living in the Bryansk oblast, the worst contaminated area of Russia after the Chernobyl accident. According to the census of 1989, the pop...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0039-2
更新日期:2006-05-01 00:00:00
abstract::The study reported in the present paper aimed to evaluate the effective energy (Eeff) of X-rays emitted from the surface of a bare X-ray probe and from different spherical applicators with various diameters, which are widely employed for low kV intraoperative radiotherapy (IORT) of breast cancer. A previously validate...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00887-2
更新日期:2021-01-03 00:00:00
abstract::The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they we...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050149
更新日期:1999-07-01 00:00:00
abstract::In the process of developing a new dosimetry system for atomic bomb survivors in Hiroshima and Nagasaki (DS02), an intercomparison study between (152)Eu and (36)Cl measurements was proposed, to reconcile the discrepancy previously observed in the Hiroshima data between measurements and calculations of thermal neutron ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0166-z
更新日期:2008-07-01 00:00:00
abstract::The major part of the liquid radioactive waste released by the Mayak Production Association (PA) radiochemical plant into the Techa river occurred in 1949-1951, but there is information on only one single radiochemical analysis of a water sample taken on 24 and 25 September 1951. These data are here used to assess the...
journal_title:Radiation and environmental biophysics
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00411-003-0182-y
更新日期:2003-04-01 00:00:00
abstract::With a model system of pBR322 plasmid DNA solution in vitro, the dose effects of radiation-induced single- and double-strand breaks (SSB and DSB) were measured and DSB was distinguished into alpha- and beta-types. Under the condition of low scavenging capacity existing in the irradiated DNA solution, SSB and alpha DSB...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110000054
更新日期:2000-06-01 00:00:00
abstract::Quantitative cancer incidence data exist for various laboratory animal models, but little of this information is usable for estimating human risks, primarily because of uncertainties about possible mechanistic differences among species. Acceptance and utilization of animal data for human risk assessment will require a...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0106-3
更新日期:2007-06-01 00:00:00
abstract::Since the early 1990s, information on radiation-exposed populations other than those exposed from the Chernobyl accident in 1986 has become increasingly available for international scientific research. It is essential to understand how the cohorts of exposed populations have been defined and what mechanisms can be use...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-001-0128-1
更新日期:2002-03-01 00:00:00
abstract::137Cs from global fallout of nuclear weapon testings in the 1950s and 1960s was determined in successive layers (0-30 cm) of eight undisturbed grassland soils in Bavaria, Germany. The maximum activity concentration was found in soil layers between 4 and 15 cm below the surface. Using the vertical distribution of the c...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050088
更新日期:1998-04-01 00:00:00