Abstract:
:Survival and G2 dalay following exposure to either 60Cobalt-gamma-rays or 241Americium-alpha-particles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared to gamma-rays. RBE values for G2 delay (4.6-9.2) were in general comparable to RBE values derived from initial slopes of survival curves (RBE alpha) but higher compared to the ratio of mean inactivation doses (RB-DML). Ataxia cells were particularly sensitive to cell killing by gamma-irradiation (D37 = 0.57 Gy), however, showed average sensitivity to alpha-particles of high LET (D37 = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Lücke-Huhle C,Comper W,Hieber L,Pech Mdoi
10.1007/BF01325466subject
Has Abstractpub_date
1982-01-01 00:00:00pages
171-85issue
3eissn
0301-634Xissn
1432-2099journal_volume
20pub_type
杂志文章abstract::Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-o...
journal_title:Radiation and environmental biophysics
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更新日期:1983-01-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326732
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journal_title:Radiation and environmental biophysics
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更新日期:2013-05-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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journal_title:Radiation and environmental biophysics
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doi:10.1007/s00411-012-0427-8
更新日期:2012-11-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211257
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050028
更新日期:1996-08-01 00:00:00
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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更新日期:1997-02-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323624
更新日期:1976-03-30 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050088
更新日期:1998-04-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0700-y
更新日期:2017-08-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-016-0636-7
更新日期:2016-05-01 00:00:00
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journal_title:Radiation and environmental biophysics
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doi:10.1007/s00411-008-0181-0
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01210458
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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journal_title:Radiation and environmental biophysics
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更新日期:1993-01-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/BF01214829
更新日期:1992-01-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01213705
更新日期:1987-01-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0137-9
更新日期:2008-02-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01210524
更新日期:1990-01-01 00:00:00
abstract::High steady-state transcriptional activity is essential for normal mitochondrial function. The requisite transcription rate is satisfied in part by high copy number of mitochondrial DNA (mtDNA). In the present study, we analyze mtDNA copy number by real-time PCR in nucleated blood cells from control mice and mice expo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0329-6
更新日期:2011-03-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-004-0257-4
更新日期:2004-12-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract::About a century ago, Conrad Röentgen discovered X-rays, and Henri Becquerel discovered a new phenomenon, which Marie and Pierre Curie later coined as radio-activity. Since their seminal work, we have learned much about the physical properties of radiation and its effects on living matter. Alas, the more we discover, t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-007-0146-8
更新日期:2008-02-01 00:00:00
abstract::The relationship between occupational exposure to extremely low-frequency electromagnetic fields and adult leukaemia has been studied extensively during the last decade. The first studies were based on crude exposure assessments, estimated through job titles, with no or only limited control confounding factors. The re...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s004110050036
更新日期:1996-11-01 00:00:00