Abstract:
:Heavy charged particle therapy, started at research institutes three decades ago, is now on the verge of entering a clinical phase. This phase has resulted from the evolution and development of various beam delivery systems and techniques with existing research accelerators and with newly built accelerators. For the first thirty years, heavy charged particle therapy was administered with a fixed horizontal beam line. In 1991, the first treatment with an isocentric gantry was administered. The development of the isocentric gantry, the newest beam delivery system, and clearly a consequence of all the experience gained at the earlier facilities has many advantages. It offers advantageous physical properties of the particles as well as being equal in the flexibility of dose delivery to the modern photon radiotherapy gantries.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Blattmann Hdoi
10.1007/BF01214829keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
219-31issue
3eissn
0301-634Xissn
1432-2099journal_volume
31pub_type
杂志文章,评审abstract::To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01325468
更新日期:1982-01-01 00:00:00
abstract::The use of Green's function has played a fundamental role in transport calculations for high-charge high-energy (HZE) ions. Two recent developments have greatly advanced the practical aspects of implementation of these methods. The first was the formulation of a closed-form solution as a multiple fragmentation perturb...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211542
更新日期:1995-08-01 00:00:00
abstract::The radiation-induced process of strand breaks on pBR322 plasmid DNA in aqueous solution for different energy electrons was studied by Monte Carlo simulation. Assumptions of induction mechanisms of single- and double-strand breaks (SSBs and DSBs) used in the simulation are that SSB is induced by OH or H reaction with ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-002-0161-8
更新日期:2002-09-01 00:00:00
abstract::Hematoporphyrin (Hp) solutions were subjected to a wide range high intensity (0.2-10.0 GW/cm2) near-UV laser pulse radiation (lambda exc = 355 nm, pulse duration 30 ps). The formation of stable Hp photoproducts was followed by UV-VIS absorption spectroscopy and liquid-gel column chromatography. As judged by the influe...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01210525
更新日期:1990-01-01 00:00:00
abstract::The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation r...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323754
更新日期:1982-01-01 00:00:00
abstract::For studies on cell membranes, mice were exposed to mixed neutron + gamma reactor-radiation in the range of total doses from 0.5 to 4.5 Gy. Changes in functional activity of plasma membranes of erythrocytes, platelets, and lymphocytes were followed by a lectin-binding technique at various intervals afterwards. The amo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01407598
更新日期:1984-01-01 00:00:00
abstract::Fluence spectra at several ground distances in Hiroshima and Nagasaki are provided along with associated fluence-to-kerma coefficients from the Dosimetry System 2002 (DS02). Also included are transmission factors for calculating expected responses of in situ sample measurements of neutron activation products such as (...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0120-5
更新日期:2007-11-01 00:00:00
abstract::The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211238
更新日期:1996-02-01 00:00:00
abstract::The effect of supplying three different stable iodine levels (about 70, 80, and 160 mg day-1) in the daily feed of four dairy cows has been studied for the excretion pattern of 131I. None of the different treatments had a statistically significant effect. A mean milk transfer coefficient of 0.015 +/- 0.001 d l-1 was d...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01212680
更新日期:1994-01-01 00:00:00
abstract::A new device for the measurement of complete laser induced fluorescence emission spectra (maxima near 690 and 735 nm) of leaves during the induction of the chlorophyll fluorescence is described. In this the excitation light (cw He/Ne laser, 632.8 nm) is switched on by a fast electro-mechanical shutter which provides a...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211213
更新日期:1992-01-01 00:00:00
abstract::The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0063-2
更新日期:2006-11-01 00:00:00
abstract::C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL). Peripheral blood was harvested from animals from 1 to 12 days after total body irradiation (TBI) to quantify the level o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0291-3
更新日期:2010-08-01 00:00:00
abstract::It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF02339804
更新日期:1975-06-13 00:00:00
abstract::About a century ago, Conrad Röentgen discovered X-rays, and Henri Becquerel discovered a new phenomenon, which Marie and Pierre Curie later coined as radio-activity. Since their seminal work, we have learned much about the physical properties of radiation and its effects on living matter. Alas, the more we discover, t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-007-0146-8
更新日期:2008-02-01 00:00:00
abstract::Investigation of cell-free DNA (cf-DNA) in body fluids, as a potential biomarker for assessing the effect of ionizing radiation on the organism, is of considerable interest. We investigated changes in the contents of cell-free mitochondrial DNA (cf-mtDNA) and cell-free nuclear DNA (cf-nDNA) in the urine of X-ray-expos...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-015-0599-0
更新日期:2015-08-01 00:00:00
abstract::Preliminary results on the spectral dependence of the absorption of light in tissue are presented and discussed with respect to medical laser application. ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323942
更新日期:1977-10-12 00:00:00
abstract::This study aimed to evaluate the biological effects of gamma irradiation on zebrafish embryos. Different doses of gamma rays (0.01, 0.05, 0.1, 0.5 and 1 Gy) were used to irradiate zebrafish embryos at three developmental stages (stage 1, 6 h post-fertilization (hpf); stage 2, 12 hpf; stage three, 24 hpf), respectively...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-016-0663-4
更新日期:2016-11-01 00:00:00
abstract::The lethal effects of high-voltage capacitor-discharges in suspensions of E. coli K12 with varying electrolytes have been examined. A reduction of more than 99.9% of living cells, dependent on the applied voltage could be proved. The bactericidal action is assumed to be due to direct effects of high electric fields. E...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01324271
更新日期:1980-01-01 00:00:00
abstract::Those working in interventional cardiology are exposed to varying radiation doses during diagnostic and interventional procedures. The work presented in this paper aimed to monitor the effective doses received by different categories of medical staff members practicing interventional cardiology procedures including se...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00862-x
更新日期:2020-11-01 00:00:00
abstract::The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01328977
更新日期:1975-06-18 00:00:00
abstract::Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01209769
更新日期:1993-01-01 00:00:00
abstract::Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323760
更新日期:1983-01-01 00:00:00
abstract::Microcalorimetric experiments on growth and maintenance metabolism of Saccharomyces strains ranging from haploid to hexaploid are described. During growth, the mean dry weight, the mean volume and the maximum heat flux of the cells are nearly linear functions of ploidy. These parameters are correlated with the cell co...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323624
更新日期:1976-03-30 00:00:00
abstract::It is shown that the properties of ATPase (EC 3.6.1.3) of Micrococcus luteus depend only to some extent on the state of the membrane to which it is attached. Its interaction with the membrane appears to be largely controlled by polar forces. It is shown, however, that the UV-sensitivity of the membrane-bound ATPase is...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323619
更新日期:1976-03-30 00:00:00
abstract::In the process of developing a new dosimetry system for atomic bomb survivors in Hiroshima and Nagasaki (DS02), an intercomparison study between (152)Eu and (36)Cl measurements was proposed, to reconcile the discrepancy previously observed in the Hiroshima data between measurements and calculations of thermal neutron ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0166-z
更新日期:2008-07-01 00:00:00
abstract::The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various param...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-012-0410-4
更新日期:2012-05-01 00:00:00
abstract::Total body Irradiation (TBI) is often used for conditioning, prior to bone marrow transplantation. Doses of 8-14 Gy in 1-8 fractions over 1-4 days are administered using low dose rate external beam radiotherapy (EBRT). When necessary, consolidation EBRT using conventional doses, fractionation and dose rate is given. T...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-009-0238-8
更新日期:2009-11-01 00:00:00
abstract::Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0728-z
更新日期:2018-05-01 00:00:00
abstract::Analyses of structural aberrations of chromosomes and of the body burden of lead-210 were carried out in a group of workers occupationally exposed to chemical pollutants and low doses of ionizing radiation during a technological process in which coal is used as fuel. A parallel study was performed in a control group o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326048
更新日期:1980-01-01 00:00:00
abstract::An extensive programme of experiments on transfer of radionuclides to aquatic species was conducted in the former USSR starting from the early 1950s. Only a few of these studies were made available in the English language literature or taken into account in international reviews of radionuclide behaviour in marine eco...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-010-0324-y
更新日期:2010-11-01 00:00:00