Abstract：
:About a century ago, Conrad Röentgen discovered X-rays, and Henri Becquerel discovered a new phenomenon, which Marie and Pierre Curie later coined as radio-activity. Since their seminal work, we have learned much about the physical properties of radiation and its effects on living matter. Alas, the more we discover, the more we appreciate the complexity of the biological processes that are triggered by radiation exposure and eventually lead (or do not lead) to disease. Equipped with modern biological methods of high-throughput experimentation, imaging, and vastly increased computational prowess, we are now entering an era where we can piece some of the multifold aspects of radiation exposure and its sequelae together, and develop a more systemic understanding of radiogenic effects such as radio-carcinogenesis than has been possible in the past. It is evident from the complexity of even the known processes that such an understanding can only be gained if it is supported by mathematical models. At this point, the construction of comprehensive models is hampered both by technical inadequacies and a paucity of appropriate data. Nonetheless, some initial steps have been taken already and the generally increased interest in systems biology may be expected to speed up future progress. In this context, we discuss in this article examples of relatively small, yet very useful models that elucidate selected aspects of the effects of exposure to ionizing radiation and may shine a light on the path before us.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Feinendegen L,Hahnfeldt P,Schadt EE,Stumpf M,Voit EOdoi
10.1007/s00411-007-0146-8subject
Has Abstractpub_date
2008-02-01 00:00:00pages
5-23issue
1eissn
0301-634Xissn
1432-2099journal_volume
47pub_type
杂志文章,评审abstract：:The use of Green's function has played a fundamental role in transport calculations for high-charge high-energy (HZE) ions. Two recent developments have greatly advanced the practical aspects of implementation of these methods. The first was the formulation of a closed-form solution as a multiple fragmentation perturb...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211542
更新日期：1995-08-01 00:00:00
abstract：:Many experimental studies are carried out to compare biological effectiveness of high dose rate (HDR) with that of low dose rate (LDR). The rational for this is the uncertainty regarding the value of the dose rate effectiveness factor (DREF) used in radiological protection. While a LDR is defined as 0.1 mGy/min or low...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00852-z
更新日期：2020-08-01 00:00:00
abstract：:To explore the expression level and the role of peroxisome proliferator-activated receptor gamma (PPAR-γ) in radiation-induced heart injury in a rat model, thirty-two Sprague-Dawley rats were divided into three groups (the control group, the 15-Gy irradiation group and the 18-Gy irradiation group). Experimental animal...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-011-0390-9
更新日期：2012-03-01 00:00:00
abstract：:Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose f...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-019-00819-9
更新日期：2020-03-01 00:00:00
abstract：:The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions dec...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-015-0623-4
更新日期：2016-03-01 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050065
更新日期：1997-09-01 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323416
更新日期：1975-12-04 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0039-2
更新日期：2006-05-01 00:00:00
abstract：:This study was undertaken to investigate the mechanism of chemical radiosensitization by halogenated bases incorporated into DNA. Radiation-induced base and sugar-phosphate backbone damage to 5-bromouridine-5'-monophosphate (5-BrUMP) was monitored using a flow system connected in series with a recording spectrophotome...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211508
更新日期：1992-01-01 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01328977
更新日期：1975-06-18 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01324230
更新日期：1981-01-01 00:00:00
abstract：:The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211238
更新日期：1996-02-01 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01325468
更新日期：1982-01-01 00:00:00
abstract：:Waterborne radioactive releases into the Techa River from the Mayak Production Association in Russia during 1949-1956 resulted in significant doses to about 30,000 persons who lived in downstream settlements. The residents were exposed to internal and external radiation. Two methods for reconstruction of the external ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-015-0611-8
更新日期：2015-11-01 00:00:00
abstract：:Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...
journal_title：Radiation and environmental biophysics
pub_type： 临床试验,杂志文章
doi：10.1007/s00411-018-0768-z
更新日期：2019-03-01 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-007-0154-8
更新日期：2008-04-01 00:00:00
abstract：:The TEL1 gene from Saccharomyces cerevisiae has been shown to be the closest sequence homologue to ATM, the gene mutated in ataxia-telangiectasia (A-T) patients. Functional homology shared between the ATM and Tell proteins has recently been demonstrated based on heterologous expression of the TEL1 gene in human cells ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-001-0125-4
更新日期：2001-12-01 00:00:00
abstract：:Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-o...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323760
更新日期：1983-01-01 00:00:00
abstract：:137Cs from global fallout of nuclear weapon testings in the 1950s and 1960s was determined in successive layers (0-30 cm) of eight undisturbed grassland soils in Bavaria, Germany. The maximum activity concentration was found in soil layers between 4 and 15 cm below the surface. Using the vertical distribution of the c...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050088
更新日期：1998-04-01 00:00:00
abstract：:Age-specific and cumulative mortality rates are presented for different cancer sites from 1970 until 1988 for the 11 individual federal states of West Germany (FRG). Sex- and age-specific evaluations are performed and temporal and regional trends in mortality from different cancer sites are revealed. In the FRG there ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01212802
更新日期：1993-01-01 00:00:00
abstract：:The method of iteratively reweighted least squares for the regression analysis of Poisson distributed chromosome aberration data is reviewed in the context of other fit procedures used in the cytogenetic literature. As an application of the resulting regression curves methods for calculating confidence intervals on do...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323412
更新日期：1983-01-01 00:00:00
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journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00835-0
更新日期：2020-05-01 00:00:00
abstract：:The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation r...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323754
更新日期：1982-01-01 00:00:00
abstract：:For the estimation of radiation doses to organisms, concentration ratios (C ( R )s) of radionuclides are required. In the present study, C(R)s of various elements were obtained as analogues of radionuclides for algae, molluscs, and crustaceans, in eight estuarine areas around Japan. The elements measured were Na, Mg, ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-010-0317-x
更新日期：2010-11-01 00:00:00
abstract：:Those working in interventional cardiology are exposed to varying radiation doses during diagnostic and interventional procedures. The work presented in this paper aimed to monitor the effective doses received by different categories of medical staff members practicing interventional cardiology procedures including se...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00862-x
更新日期：2020-11-01 00:00:00
abstract：:The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0063-2
更新日期：2006-11-01 00:00:00
abstract：:Working from the general postulate that natural selection of plant form operates so as to maximize the survival potential of a species, this paper examines the hypothesis that the mechanical support of tree foliage must approach optimality in the use of wood, i.e., that tree stems and branches will have "optimal form"...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323263
更新日期：1978-08-10 00:00:00
abstract：:The aim of this interdisciplinary project is to establish slice culture preparations from rodents and humans as a new model system for studying effects of X-rays and heavy ions within normal and tumor tissues. The advantage of such slice cultures relies on the conservation of an organotypic environment, the easy treat...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-010-0293-1
更新日期：2010-08-01 00:00:00
abstract：:Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01209769
更新日期：1993-01-01 00:00:00
abstract：:The root apex cells of Pisum sativum were irradiated in an U-240 isochronous cyclotron at the Institute for Nuclear Research of the Ukrainian National Academy of Sciences, Kyiv. Several types of micronuclei, differing in structural peculiarities, were observed in the 84 h following exposure to beams of accelerated 1H,...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01275215
更新日期：1995-06-01 00:00:00
