Abstract:
:The method of iteratively reweighted least squares for the regression analysis of Poisson distributed chromosome aberration data is reviewed in the context of other fit procedures used in the cytogenetic literature. As an application of the resulting regression curves methods for calculating confidence intervals on dose from aberration yield are described and compared, and, for the linear quadratic model lambda = beta 0 + beta 1 chi + beta 2 chi 2 a confidence interval for the ratio beta 1/ beta 2 is given. Emphasis is placed on the rationale, interpretation and the limitations of various methods from a statistical point of view.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Merkle Wdoi
10.1007/BF01323412subject
Has Abstractpub_date
1983-01-01 00:00:00pages
217-33issue
3eissn
0301-634Xissn
1432-2099journal_volume
21pub_type
杂志文章abstract::Growth rates and cell diameters were determined from 12 species of plant roots exposed to a 60-Hertz (Hz) electric field of 360 Volts per meter (V/m) in an aqueous inorganic nutrient medium [conductivity: 0.07-0.09 Siemens per meter (S/m)]. The degree of growth depression ranged from zero to nearly 100 percent of cont...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01210937
更新日期:1985-01-01 00:00:00
abstract::A Monte Carlo model is presented to study details of the energy deposition inside tracks of heavy charged particles in water vapor. The input data for most of the calculations based on the binary encounter approximation are double-differential cross sections for electron emission after heavy-ion impact. The paths of t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/BF01219334
更新日期:1994-01-01 00:00:00
abstract::The development of biophysical models of chromosome aberration induction has undergone considerable improvements in the past few years. This is mainly due to the development of new experimental techniques, such as fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC), and to a better kn...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s004110050132
更新日期:1999-05-01 00:00:00
abstract::The TEL1 gene from Saccharomyces cerevisiae has been shown to be the closest sequence homologue to ATM, the gene mutated in ataxia-telangiectasia (A-T) patients. Functional homology shared between the ATM and Tell proteins has recently been demonstrated based on heterologous expression of the TEL1 gene in human cells ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-001-0125-4
更新日期:2001-12-01 00:00:00
abstract::Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323760
更新日期:1983-01-01 00:00:00
abstract::Quantitative cancer incidence data exist for various laboratory animal models, but little of this information is usable for estimating human risks, primarily because of uncertainties about possible mechanistic differences among species. Acceptance and utilization of animal data for human risk assessment will require a...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0106-3
更新日期:2007-06-01 00:00:00
abstract::Many experimental studies are carried out to compare biological effectiveness of high dose rate (HDR) with that of low dose rate (LDR). The rational for this is the uncertainty regarding the value of the dose rate effectiveness factor (DREF) used in radiological protection. While a LDR is defined as 0.1 mGy/min or low...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00852-z
更新日期:2020-08-01 00:00:00
abstract::Stem cells surviving radiation injury may carry defects which contribute to long-term effects. The ratio of 125-iododeoxyuridine (IUdR) uptake into spleens of lethally irradiated recipient mice between day 3 and day 5 after cell transfusion revealed reduced proliferative ability (PF) of spleen seeding cells in paralle...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211733
更新日期:1986-01-01 00:00:00
abstract::Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-003-0214-7
更新日期:2004-02-01 00:00:00
abstract::Monte Carlo codes have been used for approximately 80 years to solve various problems in medical physics. In this paper, the importance of the MCNPX code in treatment planning is highlighted. As illustrative examples of the role of MCNPX in this field, some dosimetric parameters, isodose distribution curves, and figur...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00841-2
更新日期:2020-05-01 00:00:00
abstract::Results of measurements of the resuspended radioactive aerosols in the Chernobyl area are presented which were obtained soon after the Chernobyl reactor accident and in a European project in 1992-1993. The measurements were carried out with the intention of obtaining a data base for dose assessment of resuspended radi...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050065
更新日期:1997-09-01 00:00:00
abstract::At five stages of gestation, mice were exposed dorsally to ultrasonic irradiation at 1 W/cm2 (spatial and temporal average), 2 MHz, and 34 and 37 degrees C (temperature at beginning of exposure). The results indicated that ultrasonic exposure up to at least 100 s is not hazardous to a pregnant mouse or its offspring i...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323651
更新日期:1980-01-01 00:00:00
abstract::Since the early 1990s, information on radiation-exposed populations other than those exposed from the Chernobyl accident in 1986 has become increasingly available for international scientific research. It is essential to understand how the cohorts of exposed populations have been defined and what mechanisms can be use...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-001-0128-1
更新日期:2002-03-01 00:00:00
abstract::A number of approaches have been proposed to estimate the exposure of non-human biota to ionizing radiation. This paper reports an inter-comparison of the unweighted absorbed dose rates for the whole organism (compared as dose conversion coefficients, or DCCs) for both internal and external exposure, estimated by 11 o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0124-1
更新日期:2007-11-01 00:00:00
abstract::Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...
journal_title:Radiation and environmental biophysics
pub_type: 临床试验,杂志文章
doi:10.1007/s00411-018-0768-z
更新日期:2019-03-01 00:00:00
abstract::Working from the general postulate that natural selection of plant form operates so as to maximize the survival potential of a species, this paper examines the hypothesis that the mechanical support of tree foliage must approach optimality in the use of wood, i.e., that tree stems and branches will have "optimal form"...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323263
更新日期:1978-08-10 00:00:00
abstract::Beginning in 1950, people living on the banks of the Techa River received chronic low-dose-rate internal and external radiation exposures as a result of releases from the Mayak nuclear weapons plutonium production facility in the Southern Urals region of the Russian Federation. The Techa River cohort includes about 30...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-009-0257-5
更新日期:2010-05-01 00:00:00
abstract::137Cs from global fallout of nuclear weapon testings in the 1950s and 1960s was determined in successive layers (0-30 cm) of eight undisturbed grassland soils in Bavaria, Germany. The maximum activity concentration was found in soil layers between 4 and 15 cm below the surface. Using the vertical distribution of the c...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050088
更新日期:1998-04-01 00:00:00
abstract::The objective of the present work is to apply the plasma clearance parameters to strontium, previously determined in our laboratory, to improve the biokinetic and dosimetric models of strontium-90 ((90)Sr) used in radiological protection; and also to apply this data for the estimation of the radiation doses from stron...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0154-8
更新日期:2008-04-01 00:00:00
abstract::This article describes the application of a simplified Bayesian method for estimation of doses from a mixed field using cytogenetic biological dosimetry, taking as an example neutron and gamma radiation emitted from the MARIA nuclear research reactor in Poland. The Bayesian approach is a good alternative to the common...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-018-0764-3
更新日期:2019-03-01 00:00:00
abstract::This study was undertaken to investigate the mechanism of chemical radiosensitization by halogenated bases incorporated into DNA. Radiation-induced base and sugar-phosphate backbone damage to 5-bromouridine-5'-monophosphate (5-BrUMP) was monitored using a flow system connected in series with a recording spectrophotome...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211508
更新日期:1992-01-01 00:00:00
abstract::Age-specific and cumulative mortality rates are presented for different cancer sites from 1970 until 1988 for the 11 individual federal states of West Germany (FRG). Sex- and age-specific evaluations are performed and temporal and regional trends in mortality from different cancer sites are revealed. In the FRG there ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01212802
更新日期:1993-01-01 00:00:00
abstract::More accurate reconstruction of the radioactive contamination of the Techa River system in 1949-1951 has been made on the basis of refined data on the amounts and the rate of discharge of radionuclides into the Techa River from the Mayak Production Association; this has led to the development of a modified Techa River...
journal_title:Radiation and environmental biophysics
pub_type: 历史文章,杂志文章
doi:10.1007/s00411-012-0414-0
更新日期:2012-11-01 00:00:00
abstract::The root apex cells of Pisum sativum were irradiated in an U-240 isochronous cyclotron at the Institute for Nuclear Research of the Ukrainian National Academy of Sciences, Kyiv. Several types of micronuclei, differing in structural peculiarities, were observed in the 84 h following exposure to beams of accelerated 1H,...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01275215
更新日期:1995-06-01 00:00:00
abstract::Analyses of structural aberrations of chromosomes and of the body burden of lead-210 were carried out in a group of workers occupationally exposed to chemical pollutants and low doses of ionizing radiation during a technological process in which coal is used as fuel. A parallel study was performed in a control group o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326048
更新日期:1980-01-01 00:00:00
abstract::A human total-body counter was designed and built with two 20 X 10 cm NaI (Tl) crystals suspended over an "isoresponse surface" upon which the subject reclines. This surface is curved from head to knee and from left to right, so that a gamma-ray emitting object is detected with equal efficiency when placed anywhere up...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323223
更新日期:1979-04-30 00:00:00
abstract::The fluorescent intercalation complex of ethidium bromide with DNA was used as a probe to demonstrate damage in the base-pair region of DNA, due to the action of superoxide radicals. The O.2- radical itself, generated by gamma-radiolysis of oxygenated aqueous Na-formate solutions, is rather ineffective with respect to...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326732
更新日期:1984-01-01 00:00:00
abstract::The effect of negative pions (peak and plateau), photons (140 kV and 29 MeV), and 20 MeV electrons on the proliferative capacity of Ehrlich ascites carcinoma cells was investigated. Proliferative survival curves plotted for the modalities employed are presented. Under the experimental conditions used, the peak pions w...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01358287
更新日期:1979-08-10 00:00:00
abstract::An LBO (Li2B4O7) walled ionization chamber was designed to monitor the epithermal neutron fluence in boron neutron capture therapy clinical irradiation. The thermal and epithermal neutron sensitivities of the device were evaluated using accelerator neutrons from the 9Be(d, n) reaction at a deuteron energy of 4 MeV (4 ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0700-y
更新日期:2017-08-01 00:00:00
abstract::Mouse spermatogonial germ cells are highly sensitive to ionizing radiation. Lithium salts are reported to stimulate the postirradiation recovery of hematopoietic marrow cells. We have, therefore, examined whether administered lithium chloride (LiCl) would also be able to protect the mouse germinal cells against radiat...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050063
更新日期:1997-06-01 00:00:00