Statistical methods in regression and calibration analysis of chromosome aberration data.

Abstract:

:The method of iteratively reweighted least squares for the regression analysis of Poisson distributed chromosome aberration data is reviewed in the context of other fit procedures used in the cytogenetic literature. As an application of the resulting regression curves methods for calculating confidence intervals on dose from aberration yield are described and compared, and, for the linear quadratic model lambda = beta 0 + beta 1 chi + beta 2 chi 2 a confidence interval for the ratio beta 1/ beta 2 is given. Emphasis is placed on the rationale, interpretation and the limitations of various methods from a statistical point of view.

journal_name

Radiat Environ Biophys

authors

Merkle W

doi

10.1007/BF01323412

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

217-33

issue

3

eissn

0301-634X

issn

1432-2099

journal_volume

21

pub_type

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