Mechanisms of an increased level of serum iron in gamma-irradiated mice.


:The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions decreased, whereas the serum iron concentration increased. The concentration of ferrous ions in irradiated mice returned to normal at 21 day post-exposure. The concentration of reactive oxygen species in irradiated mice increased immediately following irradiation but returned to normal at 7 day post-exposure. Serum iron concentration in gamma-irradiated mice that were pretreated with reduced glutathione was significant lower (p < 0.01) than that in mice exposed to gamma radiation only. However, the serum iron concentration was still higher than that in normal mice (p < 0.01). This change was biphasic, characterized by a maximal decrease phase occurring immediately after gamma irradiation (relative to the irradiated mice) and a recovery plateau observed during the 7th and 21st day post-irradiation, but serum iron recovery was still less than that in the gamma-irradiated mice (4 Gy). In gamma-irradiated mice, ceruloplasmin activity increased and serum copper concentration decreased immediately after irradiation, and both of them were constant during the 7th and 21st day post-irradiation. It was concluded that ferrous ions in irradiated mice were oxidized to ferric ions by ionizing radiation. Free radicals induced by gamma radiation and ceruloplasmin mutually participated in this oxidation process. The ferroxidase effect of ceruloplasmin was achieved by transfer of electrons from ferrous ions to cupric ions.


Radiat Environ Biophys


Xie LH,Zhang XH,Hu XD,Min XY,Zhou QF,Zhang HQ




Has Abstract


2016-03-01 00:00:00














  • The effect of radiation in combination with carcinogens on the growth of normal urothelium in explant culture.

    abstract::Radiation is known to be carcinogenic to humans but attempts to demonstrate the process using human tissue culture models have met with little success. In the present study explants were established from urothelium and exposed to radiation and a range of chemical carcinogens, suspected promotor or metabolic agents. Th...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Mothersill C,O'Brien A,Seymour CB

    更新日期:1990-01-01 00:00:00

  • Biophysical aspects of Am-241 and Pu-241 in the environment.

    abstract::Most of plutonium released by nuclear explosions is Pu-241 which decays to Am-241. We have studied the deposition of Pu-241 and Am-241 in lichens collected since 1958 in the central part of Sweden (62.3 degrees N, 12. 4 degrees E). Comparative studies with Pu-isotopes, Pu-239 + 240 and Pu-238 were also performed. In 1...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Holm E,Persson RB

    更新日期:1978-10-12 00:00:00

  • Fixation, retention and exhalation of carrier-free 11C-labeled carbon monoxide by man.

    abstract::Carrier-free 11C-labeled carbon monoxide was produced by proton irradiation of a nitrogen gas flow target via the 14N(p, alpha)11C process followed by on-line reduction of the predominantly formed 11C-carbon dioxide with a yield of 0.4 mCi/muAmin. After appropriate quality control about 2 mCi of carrier-free 11C-carbo...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Weinreich R,Ritzl F,Feinendegen LE,Schnippering HG,Stöcklin G

    更新日期:1975-12-04 00:00:00

  • Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study.

    abstract::Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose f...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Schöllnberger H,Kaiser JC,Eidemüller M,Zablotska LB

    更新日期:2020-03-01 00:00:00

  • Criteria of applicability for autoradiography of tritium.

    abstract::Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Kellerer AM,Chen J,Roos H

    更新日期:1993-01-01 00:00:00

  • Effective dose conversion coefficients for radionuclides exponentially distributed in the ground.

    abstract::In order to provide fundamental data required for dose evaluation due to environmental exposures, effective dose conversion coefficients, that is, the effective dose rate per unit activity per unit area, were calculated for a number of potentially important radionuclides, assuming an exponential distribution in ground...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Saito K,Ishigure N,Petoussi-Henss N,Schlattl H

    更新日期:2012-11-01 00:00:00

  • Effects of lithium chloride as a potential radioprotective agent on radiation response of DNA synthesis in mouse germinal cells.

    abstract::Mouse spermatogonial germ cells are highly sensitive to ionizing radiation. Lithium salts are reported to stimulate the postirradiation recovery of hematopoietic marrow cells. We have, therefore, examined whether administered lithium chloride (LiCl) would also be able to protect the mouse germinal cells against radiat...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Bhattacharjee D,Rajan R,Krishnamoorthy L,Singh BB

    更新日期:1997-06-01 00:00:00

  • Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.

    abstract::Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Dalke C,Neff F,Bains SK,Bright S,Lord D,Reitmeir P,Rößler U,Samaga D,Unger K,Braselmann H,Wagner F,Greiter M,Gomolka M,Hornhardt S,Kunze S,Kempf SJ,Garrett L,Hölter SM,Wurst W,Rosemann M,Azimzadeh O,Tapio S,Au

    更新日期:2018-05-01 00:00:00

  • Measurement of resuspended aerosol in the Chernobyl area. Part III. Size distribution and dry deposition velocity of radioactive particles during anthropogenic enhanced resuspension.

    abstract::During anthropogenic activities, such as agricultural soil management and traffic on unpaved roads, size distribution measurements were performed of atmospheric particulate radionuclides at a site in the Chernobyl 30-km exclusion zone. Analysis of cascade impactor measurements showed an increase of the total atmospher...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Garger EK,Paretzke HG,Tschiersch J

    更新日期:1998-10-01 00:00:00

  • Modeling cell response to low doses of photon irradiation: Part 2--application to radiation-induced chromosomal aberrations in human carcinoma cells.

    abstract::The biological phenomena observed at low doses of ionizing radiation (adaptive response, bystander effects, genomic instability, etc.) are still not well understood. While at high irradiation doses, cellular death may be directly linked to DNA damage, at low doses, other cellular structures may be involved in what are...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Cunha M,Testa E,Komova OV,Nasonova EA,Mel'nikova LA,Shmakova NL,Beuve M

    更新日期:2016-03-01 00:00:00

  • p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields.

    abstract::Our recent results suggest that 50 Hz magnetic fields (MF) enhance ultraviolet (UV)-induced tumorigenesis in mouse skin. The aim of the present experiment was to study suppression of apoptosis as a possible mechanism for MF effects on skin tumorigenesis. Another aim was to test the importance of a UV and MF exposure s...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Kumlin T,Heikkinen P,Kosma VM,Alhonen L,Jänne J,Juutilainen J

    更新日期:2002-06-01 00:00:00

  • Transfer of Cl from herbage into tissues and milk products of dairy cattle and pigs.

    abstract::Cl-36 is an important component of nuclear waste. The concentrations of stable chlorine (Cl) in pig and cow tissues were measured to provide information which can be used to parameterize models of (36)Cl transfer into agricultural animals. The concentration of stable Cl in cows' milk was 1.0 +/- 0.2 g L(-1), in cow mu...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Levchuk S,Kashparov V,Lazarev N,Colle C,Howard B,Yoschenko V,Yoschenko L

    更新日期:2008-02-01 00:00:00

  • Considerations on the behavior of long-lived radionuclides in the soil.

    abstract::The migration of radionuclides from waste repositories to the biosphere potentially leads to a contamination of soil. Due to the importance of food production, the mobilisation and accumulation behaviour of long-lived radionuclides in the soil plays a key role in performance assessment studies. In this paper, the main...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Koch-Steindl H,Pröhl G

    更新日期:2001-06-01 00:00:00

  • Neutron scattering and energy deposition spectra.

    abstract::The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Coppola M,Booz J

    更新日期:1975-06-18 00:00:00

  • Leukemia incidence among people exposed to chronic radiation from the contaminated Techa River, 1953-2005.

    abstract::Beginning in 1950, people living on the banks of the Techa River received chronic low-dose-rate internal and external radiation exposures as a result of releases from the Mayak nuclear weapons plutonium production facility in the Southern Urals region of the Russian Federation. The Techa River cohort includes about 30...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Krestinina L,Preston DL,Davis FG,Epifanova S,Ostroumova E,Ron E,Akleyev A

    更新日期:2010-05-01 00:00:00

  • Measurement of resuspended aerosol in the Chernobyl area. I. Discussion of instrumentation and estimation of measurement uncertainty.

    abstract::Results of measurements of the resuspended radioactive aerosols in the Chernobyl area are presented which were obtained soon after the Chernobyl reactor accident and in a European project in 1992-1993. The measurements were carried out with the intention of obtaining a data base for dose assessment of resuspended radi...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Garger EK,Kashpur V,Belov G,Demchuk V,Tschiersch J,Wagenpfeil F,Paretzke HG,Besnus F,Holländer W,Martinez-Serrano J,Vintersved I

    更新日期:1997-09-01 00:00:00

  • Mutation induction by inhaled radon progeny modeled at the tissue level.

    abstract::The observable responses of living systems to ionizing radiation depend on the level of biological organization studied. Understanding the relationships between the responses characteristic of the different levels of organization is of crucial importance. The main objective of the present study is to investigate how s...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Madas BG,Balásházy I

    更新日期:2011-11-01 00:00:00

  • Development and testing of a revised dynamic model of radiocaesium transfer to sheep tissues.

    abstract::The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Crout NM,Beresford NA,Howard BJ,Mayes RW,Assimakopoulos PA,Vandecasteele CM

    更新日期:1996-02-01 00:00:00

  • Stem cell kinetics in spleen and bone marrow after single and fractionated irradiation of infant mice.

    abstract::The number and type of stem cells in spleen and bone marrow of mice were determined after exposure to a single dose of 150 R on day 6, to a single dose of 500 R on day 6 or day 9 or to a fractionated dose of 150 R + 350 R on day 6 and 9. The stem cells were assayed on the basis of colony forming units (CFU) in spleen ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Gerber GB,Maes J

    更新日期:1980-01-01 00:00:00

  • On the probability of interaction between elementary radiation-induced chromosomal injuries.

    abstract::Within the Theory of Dual Radiation Action, the heuristically useful function, gamma(chi), that two energy depositions, a distance chi apart, will result in observable damage can be written in terms of two more fundamental quantities: One, s(chi), describes the structure of the sensitive matrix of the cell. The other,...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Brenner DJ

    更新日期:1988-01-01 00:00:00

  • Time course solutions of the Sax-Markov binary eurejoining/misrejoining model of DNA double-strand breaks.

    abstract::The Sax-Markov binary eurejoining/misrejoining (SMBE) model is a stochastic representation of Sax's breakage-and-reunion mechanism of misrejoining DNA double-strand breaks (DSBs). In this model, to approximate DSB misrejoining probabilities that decrease with increasing distance, the nucleus is treated as a collection...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Radivoyevitch T

    更新日期:2000-12-01 00:00:00

  • Ultrasonic hysteresis in biological media.

    abstract::Non-linear mechanical response of viscoelastic strain responding media to high amplitude stress-strain is examined from a phenomenological point of view and found to lead to results compatible with empirical observations of high intensity ultrasound irradiation of brain, liver, and eye lens tissues. The proposed hyste...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Johnston RL,Dunn F

    更新日期:1981-01-01 00:00:00

  • Oxygenation of malignant tumors after localized microwave hyperthermia.

    abstract::The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation r...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Vaupel PW,Otte J,Manz R

    更新日期:1982-01-01 00:00:00

  • Residual radiation effect in the murine hematopoietic stem cell compartment.

    abstract::Stem cells surviving radiation injury may carry defects which contribute to long-term effects. The ratio of 125-iododeoxyuridine (IUdR) uptake into spleens of lethally irradiated recipient mice between day 3 and day 5 after cell transfusion revealed reduced proliferative ability (PF) of spleen seeding cells in paralle...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: von Wangenheim KH,Peterson HP,Feinendegen LE

    更新日期:1986-01-01 00:00:00

  • Influence of DNA conformation on radiation-induced single-strand breaks.

    abstract::It is usually assumed that sparsely ionizing radiation produces randomly distributed DNA breakages. This seems to be supported by the finding that in some DNA fragments single-strand scissions occur uniformly at all nucleotide sites, regardless of sequence. We performed experiments on two DNA fragments of about 300 bp...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Barone F,Belli M,Mazzei F

    更新日期:1994-01-01 00:00:00

  • The contribution of soil adhesion to radiocaesium uptake by leafy vegetables.

    abstract::The Goiânia accident, Brazil, was used as an opportunity to quantify the contributions of different mechanisms, in particular mass loading, leading to caesium uptake by leafy vegetables in a semi-urban environment contaminated with 137Cs. Soil splash contributions of 70-90% were quantified for lettuce and 50-60% for g...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Amaral EC,Paretzke HG,Campos MJ,Pires do Rio MA,Franklin M

    更新日期:1994-01-01 00:00:00

  • 5-Fluorouracil treatment after irradiation impairs recovery of bone marrow functions.

    abstract::In mice, persisting radiation-induced growth retardation of hematopoietic tissue suggested that at least part of the surviving stem cells are genetically injured. Additional mitotic stress some time after the radiation insult might remove injured stem cells, thus improving the overall recovery of the irradiated bone m...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: von Wangenheim KH,Peterson HP,Cronkite EP,Feinendegen LE

    更新日期:1987-01-01 00:00:00

  • Voxel-based computational models of real human anatomy: a review.

    abstract::Computational models of human anatomy are mathematical representations of human anatomy designed to be used in dosimetry calculations. They have been used in dosimetry calculations for radiography, radiotherapy, nuclear medicine, radiation protection and to investigate the effects of low frequency electromagnetic fiel...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Caon M

    更新日期:2004-02-01 00:00:00

  • Effects of ultrasound on the mouse exposed at different stages of gestation: acute studies.

    abstract::At five stages of gestation, mice were exposed dorsally to ultrasonic irradiation at 1 W/cm2 (spatial and temporal average), 2 MHz, and 34 and 37 degrees C (temperature at beginning of exposure). The results indicated that ultrasonic exposure up to at least 100 s is not hazardous to a pregnant mouse or its offspring i...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Stolzenberg SJ,Torbit CA,Edmonds PD,Taenzer JC

    更新日期:1980-01-01 00:00:00

  • The riboflavin-sensitized photooxidation of horseradish apoperoxidase.

    abstract::Native horseradish peroxidase, as well as its reduced and carboxymethylated form, and the apoenzyme, showed resistance to photodynamic action. Sensitivity to this action was detected only in reduced and carboxymethylated apoenzyme, when the photooxidation of its histidine residues was observed. When analyzing the bulk...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Silva E,Barrera M

    更新日期:1985-01-01 00:00:00