Mechanisms of an increased level of serum iron in gamma-irradiated mice.


:The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions decreased, whereas the serum iron concentration increased. The concentration of ferrous ions in irradiated mice returned to normal at 21 day post-exposure. The concentration of reactive oxygen species in irradiated mice increased immediately following irradiation but returned to normal at 7 day post-exposure. Serum iron concentration in gamma-irradiated mice that were pretreated with reduced glutathione was significant lower (p < 0.01) than that in mice exposed to gamma radiation only. However, the serum iron concentration was still higher than that in normal mice (p < 0.01). This change was biphasic, characterized by a maximal decrease phase occurring immediately after gamma irradiation (relative to the irradiated mice) and a recovery plateau observed during the 7th and 21st day post-irradiation, but serum iron recovery was still less than that in the gamma-irradiated mice (4 Gy). In gamma-irradiated mice, ceruloplasmin activity increased and serum copper concentration decreased immediately after irradiation, and both of them were constant during the 7th and 21st day post-irradiation. It was concluded that ferrous ions in irradiated mice were oxidized to ferric ions by ionizing radiation. Free radicals induced by gamma radiation and ceruloplasmin mutually participated in this oxidation process. The ferroxidase effect of ceruloplasmin was achieved by transfer of electrons from ferrous ions to cupric ions.


Radiat Environ Biophys


Xie LH,Zhang XH,Hu XD,Min XY,Zhou QF,Zhang HQ




Has Abstract


2016-03-01 00:00:00














  • Neutron scattering and energy deposition spectra.

    abstract::The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Coppola M,Booz J

    更新日期:1975-06-18 00:00:00

  • Transfer of Cl from herbage into tissues and milk products of dairy cattle and pigs.

    abstract::Cl-36 is an important component of nuclear waste. The concentrations of stable chlorine (Cl) in pig and cow tissues were measured to provide information which can be used to parameterize models of (36)Cl transfer into agricultural animals. The concentration of stable Cl in cows' milk was 1.0 +/- 0.2 g L(-1), in cow mu...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Levchuk S,Kashparov V,Lazarev N,Colle C,Howard B,Yoschenko V,Yoschenko L

    更新日期:2008-02-01 00:00:00

  • Reaction rate coefficients of hydroxyl radical-induced DNA single- and alpha-type double-strand breaks.

    abstract::With a model system of pBR322 plasmid DNA solution in vitro, the dose effects of radiation-induced single- and double-strand breaks (SSB and DSB) were measured and DSB was distinguished into alpha- and beta-types. Under the condition of low scavenging capacity existing in the irradiated DNA solution, SSB and alpha DSB...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Shao C,Yu Z,Saito M

    更新日期:2000-06-01 00:00:00

  • Modelling radiation-induced biological lesions: from initial energy depositions to chromosome aberrations.

    abstract::The development of biophysical models of chromosome aberration induction has undergone considerable improvements in the past few years. This is mainly due to the development of new experimental techniques, such as fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC), and to a better kn...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Ottolenghi A,Ballarini F,Merzagora M

    更新日期:1999-05-01 00:00:00

  • Induction of micronuclei in plant cells after exposure to accelerated ion irradiation.

    abstract::The root apex cells of Pisum sativum were irradiated in an U-240 isochronous cyclotron at the Institute for Nuclear Research of the Ukrainian National Academy of Sciences, Kyiv. Several types of micronuclei, differing in structural peculiarities, were observed in the 84 h following exposure to beams of accelerated 1H,...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Vasilenko A,Sidorenko PG

    更新日期:1995-06-01 00:00:00

  • Simplified Bayesian method: application in cytogenetic biological dosimetry of mixed n + γ radiation fields.

    abstract::This article describes the application of a simplified Bayesian method for estimation of doses from a mixed field using cytogenetic biological dosimetry, taking as an example neutron and gamma radiation emitted from the MARIA nuclear research reactor in Poland. The Bayesian approach is a good alternative to the common...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Słonecka I,Łukasik K,Fornalski KW

    更新日期:2019-03-01 00:00:00

  • Radiation chemical studies of sensitization by 5-bromouridine-5'-monophosphate (5-BrUMP).

    abstract::This study was undertaken to investigate the mechanism of chemical radiosensitization by halogenated bases incorporated into DNA. Radiation-induced base and sugar-phosphate backbone damage to 5-bromouridine-5'-monophosphate (5-BrUMP) was monitored using a flow system connected in series with a recording spectrophotome...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Greenstock CL,Whitehouse RP

    更新日期:1992-01-01 00:00:00

  • Late effects of local irradiation on the expression of inflammatory markers in the Arteria saphena of C57BL/6 wild-type and ApoE-knockout mice.

    abstract::Combined action of irradiation (IR), shear stress, and high blood pressure is well recognized to induce damage to vasculature, while data on pathological effects of IR in large peripheral vessels with low blood pressure are scarce. The purpose of the present study was hence to investigate time- and dose-dependent effe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Patties I,Habelt B,Rosin B,Dörr W,Hildebrandt G,Glasow A

    更新日期:2014-03-01 00:00:00

  • Genetic mechanisms of formation of radiation-induced instability of the genome and its transgenerational effects in the descendants of chronically irradiated individuals of Drosophila melanogaster.

    abstract::The article is devoted to the study of the role of intracellular mechanisms in the formation of radiation-induced genetic instability and its transgenerational effect in cells of different tissues of the descendants of Drosophila melanogaster mutant strains whose parents were exposed to chronic radiation (0.42 and 3.5...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Yushkova E

    更新日期:2020-05-01 00:00:00

  • Cause-of-death registers in radiation-contaminated areas of the Russian Federation and Kazakhstan.

    abstract::Since the early 1990s, information on radiation-exposed populations other than those exposed from the Chernobyl accident in 1986 has become increasingly available for international scientific research. It is essential to understand how the cohorts of exposed populations have been defined and what mechanisms can be use...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Winkelmann RA,Tretyakov FD,Startsev NV,Kolyado IB,Gusev BI,Grosche B,Storm HH,Hall P

    更新日期:2002-03-01 00:00:00

  • Quantitative analysis of DNA-damage response factors after sequential ion microirradiation.

    abstract::Several proteins are known to form foci at DNA sites damaged by ionizing radiation. We study DNA damage response by immunofluorescence microscopy after microirradiation of cells with energetic ions. By using microirradiation, it is possible to irradiate different regions on a single dish at different time-points and t...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Greubel C,Hable V,Drexler GA,Hauptner A,Dietzel S,Strickfaden H,Baur I,Krücken R,Cremer T,Friedl AA,Dollinger G

    更新日期:2008-11-01 00:00:00

  • A method for determining weights for excess relative risk and excess absolute risk when applied in the calculation of lifetime risk of cancer from radiation exposure.

    abstract::Radiation-related risks of cancer can be transported from one population to another population at risk, for the purpose of calculating lifetime risks from radiation exposure. Transfer via excess relative risks (ERR) or excess absolute risks (EAR) or a mixture of both (i.e., from the life span study (LSS) of Japanese a...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Walsh L,Schneider U

    更新日期:2013-03-01 00:00:00

  • Impact of the Great East Japan Earthquake on feeding methods and newborn growth at 1 month postpartum: results from the Fukushima Health Management Survey.

    abstract::This study examined the effects of three disasters (the Great East Japan Earthquake of March 11, 2011, followed by a tsunami and the Fukushima Daiichi Nuclear Power Plant accident) on feeding methods and growth in infants born after the disasters. Using results from the Fukushima Health Management Survey, Soso Distric...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Kyozuka H,Yasuda S,Kawamura M,Nomura Y,Fujimori K,Goto A,Yasumura S,Abe M

    更新日期:2016-05-01 00:00:00

  • Microirradiation of cells with energetic heavy ions.

    abstract::The ion microprobe SNAKE at the Munich 14 MV tandem accelerator achieves beam focussing by a superconducting quadrupole doublet and can make use of a broad range of ions and ion energies, from 20 MeV protons to 200 MeV gold ions. Because of these properties, SNAKE is particularly attractive for biological microbeam ex...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Hauptner A,Dietzel S,Drexler GA,Reichart P,Krücken R,Cremer T,Friedl AA,Dollinger G

    更新日期:2004-02-01 00:00:00

  • Confocal microscopy for modeling electron microbeam irradiation of skin.

    abstract::For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tiss...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Miller JH,Chrisler WB,Wang X,Sowa MB

    更新日期:2011-08-01 00:00:00

  • Induction and prevention of carcinogenesis in rat skin exposed to space radiation.

    abstract::Quantitative cancer incidence data exist for various laboratory animal models, but little of this information is usable for estimating human risks, primarily because of uncertainties about possible mechanistic differences among species. Acceptance and utilization of animal data for human risk assessment will require a...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Burns FJ,Tang MS,Frenkel K,Nádas A,Wu F,Uddin A,Zhang R

    更新日期:2007-06-01 00:00:00

  • Correlation between initial chromatid damage and survival of various cell lines exposed to heavy charged particles.

    abstract::The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Jianshe Y,Xigang J,Wenjian L,Zhuanzi W,Guangming Z,Jufang W,Bingrong D,Qingxiang G,Linda W

    更新日期:2006-11-01 00:00:00

  • Reference man for radiological protection: 71 chemical elements' content of the prostate gland (normal and cancerous).

    abstract::Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Zaichick V,Wynchank S

    更新日期:2021-01-02 00:00:00

  • Effective energy assessment during breast cancer intraoperative radiotherapy by low-energy X-rays: A Monte Carlo study.

    abstract::The study reported in the present paper aimed to evaluate the effective energy (Eeff) of X-rays emitted from the surface of a bare X-ray probe and from different spherical applicators with various diameters, which are widely employed for low kV intraoperative radiotherapy (IORT) of breast cancer. A previously validate...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Shamsabadi R,Baghani HR,Mowlavi AA,Azadegan B

    更新日期:2021-01-03 00:00:00

  • Reconstruction of the radionuclide spectrum of liquid radioactive waste released into the Techa river in 1949-1951.

    abstract::The major part of the liquid radioactive waste released by the Mayak Production Association (PA) radiochemical plant into the Techa river occurred in 1949-1951, but there is information on only one single radiochemical analysis of a water sample taken on 24 and 25 September 1951. These data are here used to assess the...

    journal_title:Radiation and environmental biophysics

    pub_type: 历史文章,杂志文章,评审


    authors: Mokrov YG

    更新日期:2003-04-01 00:00:00

  • Absorption, retention and tissue distribution of radiocaesium in reindeer: effects of diet and radiocaesium source.

    abstract::Radiocaesium absorption and retention in reindeer (Rangifer tarandus) calves was compared in groups fed diets containing different proportions of lichen and concentrates, and different chemical forms of radiocaesium ((134)CsCl in solution or fallout from the Chernobyl accident). Daily intakes of fallout radiocaesium w...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Skuterud L,Pedersen Ø,Staaland H,Røed KH,Salbu B,Liken A,Hove K

    更新日期:2004-12-01 00:00:00

  • Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.

    abstract::Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Dalke C,Neff F,Bains SK,Bright S,Lord D,Reitmeir P,Rößler U,Samaga D,Unger K,Braselmann H,Wagner F,Greiter M,Gomolka M,Hornhardt S,Kunze S,Kempf SJ,Garrett L,Hölter SM,Wurst W,Rosemann M,Azimzadeh O,Tapio S,Au

    更新日期:2018-05-01 00:00:00

  • Blood clearance and occupational exposure for 177Lu-DOTATATE compared to 177Lu-PSMA radionuclide therapy.

    abstract::The main target of this work is to examine blood clearance and external exposure for 177Lu-DOTATATE compared with new emerging 177Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq 177Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq 177Lu-PSMA. Dose ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Abuqbeitah M,Demir M,Uslu-Beşli L,Yeyin N,Sönmezoğlu K

    更新日期:2018-03-01 00:00:00

  • Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE).

    abstract::Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Langner I,Blettner M,Gundestrup M,Storm H,Aspholm R,Auvinen A,Pukkala E,Hammer GP,Zeeb H,Hrafnkelsson J,Rafnsson V,Tulinius H,De Angelis G,Verdecchia A,Haldorsen T,Tveten U,Eliasch H,Hammar N,Linnersjö A

    更新日期:2004-02-01 00:00:00

  • Rate constants studies of the dye-sensitized photoinactivation of lysozyme.

    abstract::The rate constants for the photodynamic inactivation of hen egg-white lysozyme at different temperatures were studied. Arrhenius plots of the methylene blue sensitized photo-inactivation of lysozyme gave an experimental activation energy of 7.5 kcal/mol. The rate constants for the photodynamic inactivation of lysozyme...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Silva E

    更新日期:1979-02-23 00:00:00

  • Radiation-epidemiological studies of thyroid cancer incidence among children and adolescents in the Bryansk oblast of Russia after the Chernobyl accident (1991-2001 follow-up period).

    abstract::In this study, thyroid cancer incidence (follow-up period: 1991-2001) has been analyzed, including persons who were exposed as children at an age between 0 and 17 years and who are living in the Bryansk oblast, the worst contaminated area of Russia after the Chernobyl accident. According to the census of 1989, the pop...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Ivanov VK,Gorski AI,Tsyb AF,Maksioutov MA,Tumanov KA,Vlasov OK

    更新日期:2006-05-01 00:00:00

  • Early hematopoiesis inhibition under chronic radiation exposure in humans.

    abstract::The major goal of this study was to identify and quantitatively describe the association between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing radiation and cellularity of peripheral blood cell lines. About 3,200 hemograms (i.e., spectra of blood counts) obtained over the years of maxim...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Akleyev AV,Akushevich IV,Dimov GP,Veremeyeva GA,Varfolomeyeva TA,Ukraintseva SV,Yashin AI

    更新日期:2010-05-01 00:00:00

  • Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.

    abstract::The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various param...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Schöllnberger H,Kaiser JC,Jacob P,Walsh L

    更新日期:2012-05-01 00:00:00

  • Subtraction of background damage in PFGE experiments on DNA fragment-size distributions.

    abstract::The non-random distribution of DNA breakage in pulsed-field gel electrophoresis (PFGE) experiments poses a problem of proper subtraction of the background damage to obtain a fragment-size distribution due to radiation only. As been pointed out by various authors, a naive bin-to-bin subtraction of the background signal...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Ponomarev AL,Belli M,Hahnfeldt PJ,Hlatky L,Sachs RK,Cucinotta FA

    更新日期:2007-06-01 00:00:00

  • Influence of human biokinetics of strontium on internal ingestion dose of 90Sr and absorbed dose of 89Sr to organs and metastases.

    abstract::The objective of the present work is to apply the plasma clearance parameters to strontium, previously determined in our laboratory, to improve the biokinetic and dosimetric models of strontium-90 ((90)Sr) used in radiological protection; and also to apply this data for the estimation of the radiation doses from stron...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Li WB,Höllriegl V,Roth P,Oeh U

    更新日期:2008-04-01 00:00:00