Mechanisms of an increased level of serum iron in gamma-irradiated mice.


:The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions decreased, whereas the serum iron concentration increased. The concentration of ferrous ions in irradiated mice returned to normal at 21 day post-exposure. The concentration of reactive oxygen species in irradiated mice increased immediately following irradiation but returned to normal at 7 day post-exposure. Serum iron concentration in gamma-irradiated mice that were pretreated with reduced glutathione was significant lower (p < 0.01) than that in mice exposed to gamma radiation only. However, the serum iron concentration was still higher than that in normal mice (p < 0.01). This change was biphasic, characterized by a maximal decrease phase occurring immediately after gamma irradiation (relative to the irradiated mice) and a recovery plateau observed during the 7th and 21st day post-irradiation, but serum iron recovery was still less than that in the gamma-irradiated mice (4 Gy). In gamma-irradiated mice, ceruloplasmin activity increased and serum copper concentration decreased immediately after irradiation, and both of them were constant during the 7th and 21st day post-irradiation. It was concluded that ferrous ions in irradiated mice were oxidized to ferric ions by ionizing radiation. Free radicals induced by gamma radiation and ceruloplasmin mutually participated in this oxidation process. The ferroxidase effect of ceruloplasmin was achieved by transfer of electrons from ferrous ions to cupric ions.


Radiat Environ Biophys


Xie LH,Zhang XH,Hu XD,Min XY,Zhou QF,Zhang HQ




Has Abstract


2016-03-01 00:00:00














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    abstract::Within the Theory of Dual Radiation Action, the heuristically useful function, gamma(chi), that two energy depositions, a distance chi apart, will result in observable damage can be written in terms of two more fundamental quantities: One, s(chi), describes the structure of the sensitive matrix of the cell. The other,...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Brenner DJ

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  • Are cancer risks associated with exposures to ionising radiation from internal emitters greater than those in the Japanese A-bomb survivors?

    abstract::After ingestion or inhalation of radionuclides, internal organs of the human body will be exposed to ionising radiation. Current risk estimates of radiation-associated cancer from internal emitters are largely based on extrapolation of risk from high-dose externally exposed groups. Concerns have been expressed that ex...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,meta分析


    authors: Little MP,Hall P,Charles MW

    更新日期:2007-11-01 00:00:00

  • The effects of simulating a realistic eye model on the eye dose of an adult male undergoing head computed tomography.

    abstract::In head computed tomography, radiation upon the eye lens (as an organ with high radiosensitivity) may cause lenticular opacity and cataracts. Therefore, quantitative dose assessment due to exposure of the eye lens and surrounding tissue is a matter of concern. For this purpose, an accurate eye model with realistic geo...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Akhlaghi P,Ebrahimi-Khankook A,Vejdani-Noghreiyan A

    更新日期:2017-05-01 00:00:00

  • Changes in the cellularity of the cortex of human hairs as an indicator of radiation exposure.

    abstract::Growing hair follicles with their rapid cell proliferation would be expected to be sensitive organs to cytotoxic agents such as radiation. Various abnormalities in the hair and hair follicles have been reported in the past. Changes in the number of cells in the newly forming hair cortex have been shown in the mouse to...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Potten CS,Burt PA,Roberts SA,Deshpande NA,Williams PC,Ramsden J

    更新日期:1996-05-01 00:00:00

  • Response of membrane-bound ATPase of Micrococcus luteus to heat and ultraviolet light.

    abstract::It is shown that the properties of ATPase (EC of Micrococcus luteus depend only to some extent on the state of the membrane to which it is attached. Its interaction with the membrane appears to be largely controlled by polar forces. It is shown, however, that the UV-sensitivity of the membrane-bound ATPase is...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Volotovskij J,Risi S,Dose K

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  • Photochemically induced cross-links between DNA and alcohol dehydrogenase or salmine, respectively.

    abstract::Model experiments with two structurally different proteins (alcohol dehydrogenase and salmine) show that glycine, alanine, and tyrosine are by far more frequently involved in photochemically induced cross-link formations with DNA than is cysteine. The yields for cross-link formation of thymidine with salmine (cysteine...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Toth B,Dose K

    更新日期:1976-07-30 00:00:00

  • Residual radiation effect in the murine spleen. In situ measurement by 125-iodo-deoxyuridine retention.

    abstract::To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Hübner GE,von Wangenheim KH,Feinendegen LE

    更新日期:1982-01-01 00:00:00

  • 5-Fluorouracil treatment after irradiation impairs recovery of bone marrow functions.

    abstract::In mice, persisting radiation-induced growth retardation of hematopoietic tissue suggested that at least part of the surviving stem cells are genetically injured. Additional mitotic stress some time after the radiation insult might remove injured stem cells, thus improving the overall recovery of the irradiated bone m...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: von Wangenheim KH,Peterson HP,Cronkite EP,Feinendegen LE

    更新日期:1987-01-01 00:00:00

  • Voxel-based computational models of real human anatomy: a review.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Caon M

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    journal_title:Radiation and environmental biophysics

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    authors: Walsh L

    更新日期:2013-03-01 00:00:00

  • Neutron scattering and energy deposition spectra.

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    journal_title:Radiation and environmental biophysics

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    authors: Coppola M,Booz J

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    authors: Vahabi SM,Shamsaie Zafarghandi M

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    authors: Ulanowski A,Kaiser JC,Schneider U,Walsh L

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    authors: Shao C,Yu Z,Saito M

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    authors: Heidenreich WF,Collier C,Morlier JP,Cross FT,Kaiser JC,Monchaux G

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    authors: Cao JP,Meyn MS,Eckardt-Schupp F,Fritz E

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    authors: Shenoy MA,Singh BB

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    authors: Vives I Batlle J,Sazykina TG,Kryshev A,Monte L,Kawaguchi I

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    journal_title:Radiation and environmental biophysics

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    authors: Takata H,Aono T,Tagami K,Uchida S

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    journal_title:Radiation and environmental biophysics

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    authors: King D,Loucks OL

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    authors: Feinendegen L,Hahnfeldt P,Schadt EE,Stumpf M,Voit EO

    更新日期:2008-02-01 00:00:00

  • Measurement of activity concentrations of 40K, 226Ra and 232Th for assessment of radiation hazards from soils of the southwestern region of Nigeria.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Ajayi OS

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  • DS02 fluence spectra for neutrons and gamma rays at Hiroshima and Nagasaki with fluence-to-kerma coefficients and transmission factors for sample measurements.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Egbert SD,Kerr GD,Cullings HM

    更新日期:2007-11-01 00:00:00

  • Transfer of Cl from herbage into tissues and milk products of dairy cattle and pigs.

    abstract::Cl-36 is an important component of nuclear waste. The concentrations of stable chlorine (Cl) in pig and cow tissues were measured to provide information which can be used to parameterize models of (36)Cl transfer into agricultural animals. The concentration of stable Cl in cows' milk was 1.0 +/- 0.2 g L(-1), in cow mu...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Levchuk S,Kashparov V,Lazarev N,Colle C,Howard B,Yoschenko V,Yoschenko L

    更新日期:2008-02-01 00:00:00

  • Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Ghosh D,Dey SK,Saha C

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  • The IRI-DICE hypothesis: ionizing radiation-induced DSBs may have a functional role for non-deterministic responses at low doses.

    abstract::Low-dose ionizing radiation (IR) responses remain an unresolved issue in radiation biology and risk assessment. Accurate knowledge of low-dose responses is important for estimation of normal tissue risk in cancer radiotherapy or health risks from occupational or hazard exposure. Cellular responses to low-dose IR appea...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Langen B,Helou K,Forssell-Aronsson E

    更新日期:2020-08-01 00:00:00

  • Influence of human biokinetics of strontium on internal ingestion dose of 90Sr and absorbed dose of 89Sr to organs and metastases.

    abstract::The objective of the present work is to apply the plasma clearance parameters to strontium, previously determined in our laboratory, to improve the biokinetic and dosimetric models of strontium-90 ((90)Sr) used in radiological protection; and also to apply this data for the estimation of the radiation doses from stron...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Li WB,Höllriegl V,Roth P,Oeh U

    更新日期:2008-04-01 00:00:00

  • Are mouse lens epithelial cells more sensitive to γ-irradiation than lymphocytes?

    abstract::In this pilot study we compared for the first time the radiation sensitivity of mouse lens epithelial cells (LECs) and mouse lymphocytes. We freshly prepared LECs and lymphocytes and irradiated them with γ-rays ((137)Cs; doses ranging from 0.25 to 2 Gy). DNA damage and repair were evaluated by alkaline comet assay and...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Bannik K,Rössler U,Faus-Kessler T,Gomolka M,Hornhardt S,Dalke C,Klymenko O,Rosemann M,Trott KR,Atkinson M,Kulka U,Graw J

    更新日期:2013-05-01 00:00:00