Abstract：
:A method which allows growth of normal human tissue to be studied in vitro is used to investigate possible interactive effects of radiation and environmentally important carcinogens on oesophageal and urothelial cell growth. Carcinogens chosen were selected for their known or suspected effect on the oesophageal mucosa or urothelium in vivo. The results indicate that with carcinogens alone concentrations can be identified that result in increased proliferation of cells. With radiation alone inhibition of cell proliferation occurs at all dose points examined. However, at precise combinations of radiation and carcinogen, greatly enhanced cell proliferation could be detected, suggesting a synergistic interaction between the two agents. The results may have implications for the design and interpretation of experiments aimed at elucidating early or premalignant changes in epithelial tissues and may indicate hitherto unsuspected interactions between radiation and environmentally important carcinogens.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Mothersill C,Cusack A,Seymour CBdoi
10.1007/BF01211257subject
Has Abstractpub_date
1989-01-01 00:00:00pages
203-12issue
3eissn
0301-634Xissn
1432-2099journal_volume
28pub_type
杂志文章abstract：:The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various param...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-012-0410-4
更新日期：2012-05-01 00:00:00
abstract：:The effect of supplying three different stable iodine levels (about 70, 80, and 160 mg day-1) in the daily feed of four dairy cows has been studied for the excretion pattern of 131I. None of the different treatments had a statistically significant effect. A mean milk transfer coefficient of 0.015 +/- 0.001 d l-1 was d...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01212680
更新日期：1994-01-01 00:00:00
abstract：:Dose conversion coefficients (DCCs) for assessment of internal and external radiation exposures to terrestrial and aquatic biota are compiled for 75 radionuclides, for 14 terrestrial and 22 aquatic reference organisms. DCC values for internal exposure are calculated based on a homogeneous distribution of the radionucl...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-008-0159-y
更新日期：2008-04-01 00:00:00
abstract：:The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation r...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323754
更新日期：1982-01-01 00:00:00
abstract：:Ehrlich ascites tumour cells were irradiated with negative pions at different positions in the plateau and the peak of the depth absorbed dose curve. Dose-survival curves for immediate testing of the viability of the cells are given and are compared with other types of radiations in use for therapy. From the data obta...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01358286
更新日期：1979-08-10 00:00:00
abstract：:For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tiss...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-011-0371-z
更新日期：2011-08-01 00:00:00
abstract：:In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for th...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/BF01209747
更新日期：1995-11-01 00:00:00
abstract：:Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00884-5
更新日期：2021-01-02 00:00:00
abstract：:Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...
journal_title：Radiation and environmental biophysics
pub_type： 临床试验,杂志文章
doi：10.1007/s00411-018-0768-z
更新日期：2019-03-01 00:00:00
abstract：:This article describes the application of a simplified Bayesian method for estimation of doses from a mixed field using cytogenetic biological dosimetry, taking as an example neutron and gamma radiation emitted from the MARIA nuclear research reactor in Poland. The Bayesian approach is a good alternative to the common...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-018-0764-3
更新日期：2019-03-01 00:00:00
abstract：:The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01210512
更新日期：1991-01-01 00:00:00
abstract：:High steady-state transcriptional activity is essential for normal mitochondrial function. The requisite transcription rate is satisfied in part by high copy number of mitochondrial DNA (mtDNA). In the present study, we analyze mtDNA copy number by real-time PCR in nucleated blood cells from control mice and mice expo...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-010-0329-6
更新日期：2011-03-01 00:00:00
abstract：:The effects of single pulses and multiple pulses of 7 MV electrons on micronuclei (MN) induction in cytokinesis-blocked human peripheral blood lymphocytes (PBLs) were investigated over a wide range of dose rates per pulse (instantaneous dose rate). PBLs were exposed to graded doses of 2, 3, 4, 6, and 8 Gy of single el...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-011-0353-1
更新日期：2011-05-01 00:00:00
abstract：:The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01328977
更新日期：1975-06-18 00:00:00
abstract：:Combined action of irradiation (IR), shear stress, and high blood pressure is well recognized to induce damage to vasculature, while data on pathological effects of IR in large peripheral vessels with low blood pressure are scarce. The purpose of the present study was hence to investigate time- and dose-dependent effe...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-013-0492-7
更新日期：2014-03-01 00:00:00
abstract：:The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with d...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-015-0600-y
更新日期：2015-08-01 00:00:00
abstract：:The work reported here was originally motivated by a discussion of Monte Carlo computer codes for electron transport in water given in Report No. 130 by the National Council on Radiation Protection and Measurements (NCRP). It was pointed out (correctly) that a published depth-dose distribution calculated by the Oak Ri...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-003-0201-z
更新日期：2003-10-01 00:00:00
abstract：:In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-012-0401-5
更新日期：2012-05-01 00:00:00
abstract：:For studies on cell membranes, mice were exposed to mixed neutron + gamma reactor-radiation in the range of total doses from 0.5 to 4.5 Gy. Changes in functional activity of plasma membranes of erythrocytes, platelets, and lymphocytes were followed by a lectin-binding technique at various intervals afterwards. The amo...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01407598
更新日期：1984-01-01 00:00:00
abstract：:Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01209769
更新日期：1993-01-01 00:00:00
abstract：:In the process of developing a new dosimetry system for atomic bomb survivors in Hiroshima and Nagasaki (DS02), an intercomparison study between (152)Eu and (36)Cl measurements was proposed, to reconcile the discrepancy previously observed in the Hiroshima data between measurements and calculations of thermal neutron ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-008-0166-z
更新日期：2008-07-01 00:00:00
abstract：:The article is devoted to the study of the role of intracellular mechanisms in the formation of radiation-induced genetic instability and its transgenerational effect in cells of different tissues of the descendants of Drosophila melanogaster mutant strains whose parents were exposed to chronic radiation (0.42 and 3.5...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00833-2
更新日期：2020-05-01 00:00:00
abstract：:Cl-36 is an important component of nuclear waste. The concentrations of stable chlorine (Cl) in pig and cow tissues were measured to provide information which can be used to parameterize models of (36)Cl transfer into agricultural animals. The concentration of stable Cl in cows' milk was 1.0 +/- 0.2 g L(-1), in cow mu...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-007-0137-9
更新日期：2008-02-01 00:00:00
abstract：:Monte Carlo codes have been used for approximately 80 years to solve various problems in medical physics. In this paper, the importance of the MCNPX code in treatment planning is highlighted. As illustrative examples of the role of MCNPX in this field, some dosimetric parameters, isodose distribution curves, and figur...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00841-2
更新日期：2020-05-01 00:00:00
abstract：:Working from the general postulate that natural selection of plant form operates so as to maximize the survival potential of a species, this paper examines the hypothesis that the mechanical support of tree foliage must approach optimality in the use of wood, i.e., that tree stems and branches will have "optimal form"...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323263
更新日期：1978-08-10 00:00:00
abstract：:To explore possible applications of iodoacetate (IA), a glycolytic inhibitor, in cancer treatment, we screened its cytotoxicity and radioprotective/sensitizing efficacy in three different mammalian cell lines; A549 (human lung carcinoma), MCF7 (human mammary cancer), a non-cancerous CHO (Chinese hamster ovary) cells a...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-017-0699-0
更新日期：2017-08-01 00:00:00
abstract：:The effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate (cAMP) in smooth muscle preparations from frog lung was studied. cAMP, given as dibutyryl salt (dib-cAMP) inhibited the radiation induced contractions of the muscle in a manner similar to the action of theophylline. In v...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323750
更新日期：1982-01-01 00:00:00
abstract：:In mice, persisting radiation-induced growth retardation of hematopoietic tissue suggested that at least part of the surviving stem cells are genetically injured. Additional mitotic stress some time after the radiation insult might remove injured stem cells, thus improving the overall recovery of the irradiated bone m...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211410
更新日期：1987-01-01 00:00:00
abstract：:Activity concentrations of the selected radionuclides (40)K, (226)Ra and (232)Th were measured in surface soil samples collected from 38 cities in the southwest region of Nigeria by means of gamma spectroscopy with a high-purity germanium detector. Measured activity concentration values of (40)K varied from 34.9 +/- 4...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-009-0225-0
更新日期：2009-08-01 00:00:00
abstract：:Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,meta分析
doi：10.1007/s00411-018-0770-5
更新日期：2019-03-01 00:00:00
