Abstract:
:For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tissues. Employing high-resolution confocal microscopy, we have determined the spatial distribution, size, and shape of epidermal keratinocyte nuclei for the full-thickness EpiDerm™ skin model (MatTek, Ashland, VA). Application of these data to calculate the microdosimetry and microdistribution of energy deposition by an electron microbeam is discussed.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Miller JH,Chrisler WB,Wang X,Sowa MBdoi
10.1007/s00411-011-0371-zsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
365-9issue
3eissn
0301-634Xissn
1432-2099journal_volume
50pub_type
杂志文章abstract::Computational models of human anatomy are mathematical representations of human anatomy designed to be used in dosimetry calculations. They have been used in dosimetry calculations for radiography, radiotherapy, nuclear medicine, radiation protection and to investigate the effects of low frequency electromagnetic fiel...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
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abstract::In this work, direct DNA damage induced by low-energy electrons (<5 keV) is simulated using Monte Carlo methods, and the resulting yield of various strand breaks and base damages in cellular environment is presented. The simulation is based on a new inelastic cross section for the production of electron track structur...
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-002-0161-8
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00411-017-0700-y
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pub_type: 杂志文章
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doi:10.1007/s00411-008-0194-8
更新日期:2009-02-01 00:00:00
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更新日期:2010-05-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323679
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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abstract::The effect of supplying three different stable iodine levels (about 70, 80, and 160 mg day-1) in the daily feed of four dairy cows has been studied for the excretion pattern of 131I. None of the different treatments had a statistically significant effect. A mean milk transfer coefficient of 0.015 +/- 0.001 d l-1 was d...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01212680
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journal_title:Radiation and environmental biophysics
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Radiation and environmental biophysics
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0137-9
更新日期:2008-02-01 00:00:00
abstract::The biological phenomena observed at low doses of ionizing radiation (adaptive response, bystander effects, genomic instability, etc.) are still not well understood. While at high irradiation doses, cellular death may be directly linked to DNA damage, at low doses, other cellular structures may be involved in what are...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-011-0382-9
更新日期:2011-11-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF02176794
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323619
更新日期:1976-03-30 00:00:00
abstract::About a century ago, Conrad Röentgen discovered X-rays, and Henri Becquerel discovered a new phenomenon, which Marie and Pierre Curie later coined as radio-activity. Since their seminal work, we have learned much about the physical properties of radiation and its effects on living matter. Alas, the more we discover, t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-007-0146-8
更新日期:2008-02-01 00:00:00
abstract::C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL). Peripheral blood was harvested from animals from 1 to 12 days after total body irradiation (TBI) to quantify the level o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0291-3
更新日期:2010-08-01 00:00:00