Survival of diploid yeast cells to bleomycin in combination with UV-light or hyperthermia.

Abstract:

:In the present work we have investigated the possible interaction between Bleomycin (B) and UV light or hyperthermia (HT) in the induction of lethal events in diploid yeast populations in the stationary phase of growth. UV and B acting as single agents determine sigmoid survival curves. The combination of UV + B produces different degrees of sensitization depending on dose ranges. For [B] = 7.5 micrograms/ml combined with different UV fluences an exponential course is observed, suggesting overlapping lesion specificity of the involved repair pathways (excision and recombination). The hyperthermia plus Bleomycin treatment produces different degrees of inactivation depending on the sequences. Maximal inactivation effect was obtained for the sequence B + HT. In the case of HT + B ([B] greater than 7.5 micrograms/ml) the obtained sensitization is lower.

journal_name

Radiat Environ Biophys

authors

Barrios E,Candreva EC,Nunes E

doi

10.1007/BF01219348

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

139-45

issue

2

eissn

0301-634X

issn

1432-2099

journal_volume

30

pub_type

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