Abstract:
:In the present work we have investigated the possible interaction between Bleomycin (B) and UV light or hyperthermia (HT) in the induction of lethal events in diploid yeast populations in the stationary phase of growth. UV and B acting as single agents determine sigmoid survival curves. The combination of UV + B produces different degrees of sensitization depending on dose ranges. For [B] = 7.5 micrograms/ml combined with different UV fluences an exponential course is observed, suggesting overlapping lesion specificity of the involved repair pathways (excision and recombination). The hyperthermia plus Bleomycin treatment produces different degrees of inactivation depending on the sequences. Maximal inactivation effect was obtained for the sequence B + HT. In the case of HT + B ([B] greater than 7.5 micrograms/ml) the obtained sensitization is lower.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Barrios E,Candreva EC,Nunes Edoi
10.1007/BF01219348subject
Has Abstractpub_date
1991-01-01 00:00:00pages
139-45issue
2eissn
0301-634Xissn
1432-2099journal_volume
30pub_type
杂志文章abstract::For studies on cell membranes, mice were exposed to mixed neutron + gamma reactor-radiation in the range of total doses from 0.5 to 4.5 Gy. Changes in functional activity of plasma membranes of erythrocytes, platelets, and lymphocytes were followed by a lectin-binding technique at various intervals afterwards. The amo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01407598
更新日期:1984-01-01 00:00:00
abstract::It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF02339804
更新日期:1975-06-13 00:00:00
abstract::To explore possible applications of iodoacetate (IA), a glycolytic inhibitor, in cancer treatment, we screened its cytotoxicity and radioprotective/sensitizing efficacy in three different mammalian cell lines; A549 (human lung carcinoma), MCF7 (human mammary cancer), a non-cancerous CHO (Chinese hamster ovary) cells a...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0699-0
更新日期:2017-08-01 00:00:00
abstract::Several proteins are known to form foci at DNA sites damaged by ionizing radiation. We study DNA damage response by immunofluorescence microscopy after microirradiation of cells with energetic ions. By using microirradiation, it is possible to irradiate different regions on a single dish at different time-points and t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0181-0
更新日期:2008-11-01 00:00:00
abstract::The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentr...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211238
更新日期:1996-02-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050065
更新日期:1997-09-01 00:00:00
abstract::The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and i...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0267-3
更新日期:2010-05-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01325468
更新日期:1982-01-01 00:00:00
abstract::Total body Irradiation (TBI) is often used for conditioning, prior to bone marrow transplantation. Doses of 8-14 Gy in 1-8 fractions over 1-4 days are administered using low dose rate external beam radiotherapy (EBRT). When necessary, consolidation EBRT using conventional doses, fractionation and dose rate is given. T...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-009-0238-8
更新日期:2009-11-01 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323263
更新日期:1978-08-10 00:00:00
abstract::An LBO (Li2B4O7) walled ionization chamber was designed to monitor the epithermal neutron fluence in boron neutron capture therapy clinical irradiation. The thermal and epithermal neutron sensitivities of the device were evaluated using accelerator neutrons from the 9Be(d, n) reaction at a deuteron energy of 4 MeV (4 ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0700-y
更新日期:2017-08-01 00:00:00
abstract::The number and type of stem cells in spleen and bone marrow of mice were determined after exposure to a single dose of 150 R on day 6, to a single dose of 500 R on day 6 or day 9 or to a fractionated dose of 150 R + 350 R on day 6 and 9. The stem cells were assayed on the basis of colony forming units (CFU) in spleen ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01324267
更新日期:1980-01-01 00:00:00
abstract::Microcalorimetry, in combination with conventional methods for determining metabolic activity, opens the possibility to study the efficiency with which ATP, produced as a result of metabolic activity, is utilized by the cell for energy-requiring synthetic reactions. Using commercial baker's yeast as a test organism an...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323416
更新日期:1975-12-04 00:00:00
abstract::Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00884-5
更新日期:2021-01-02 00:00:00
abstract::Investigation of cell-free DNA (cf-DNA) in body fluids, as a potential biomarker for assessing the effect of ionizing radiation on the organism, is of considerable interest. We investigated changes in the contents of cell-free mitochondrial DNA (cf-mtDNA) and cell-free nuclear DNA (cf-nDNA) in the urine of X-ray-expos...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-015-0599-0
更新日期:2015-08-01 00:00:00
abstract::C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL). Peripheral blood was harvested from animals from 1 to 12 days after total body irradiation (TBI) to quantify the level o...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0291-3
更新日期:2010-08-01 00:00:00
abstract::Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acti...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-005-0006-3
更新日期:2005-10-01 00:00:00
abstract::A Monte Carlo model is presented to study details of the energy deposition inside tracks of heavy charged particles in water vapor. The input data for most of the calculations based on the binary encounter approximation are double-differential cross sections for electron emission after heavy-ion impact. The paths of t...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/BF01219334
更新日期:1994-01-01 00:00:00
abstract::The method of iteratively reweighted least squares for the regression analysis of Poisson distributed chromosome aberration data is reviewed in the context of other fit procedures used in the cytogenetic literature. As an application of the resulting regression curves methods for calculating confidence intervals on do...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323412
更新日期:1983-01-01 00:00:00
abstract::High steady-state transcriptional activity is essential for normal mitochondrial function. The requisite transcription rate is satisfied in part by high copy number of mitochondrial DNA (mtDNA). In the present study, we analyze mtDNA copy number by real-time PCR in nucleated blood cells from control mice and mice expo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-010-0329-6
更新日期:2011-03-01 00:00:00
abstract::Most of plutonium released by nuclear explosions is Pu-241 which decays to Am-241. We have studied the deposition of Pu-241 and Am-241 in lichens collected since 1958 in the central part of Sweden (62.3 degrees N, 12. 4 degrees E). Comparative studies with Pu-isotopes, Pu-239 + 240 and Pu-238 were also performed. In 1...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF02176794
更新日期:1978-10-12 00:00:00
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journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-004-0257-4
更新日期:2004-12-01 00:00:00
abstract::The potential mechanisms underlying the increase in serum iron concentration in gamma-irradiated mice were studied. The gamma irradiation dose used was 4 Gy, and cobalt-60 ((60)Co) source was used for the irradiation. The dose rate was 0.25 Gy/min. In the serum of irradiated mice, the concentration of ferrous ions dec...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-015-0623-4
更新日期:2016-03-01 00:00:00
abstract::The root apex cells of Pisum sativum were irradiated in an U-240 isochronous cyclotron at the Institute for Nuclear Research of the Ukrainian National Academy of Sciences, Kyiv. Several types of micronuclei, differing in structural peculiarities, were observed in the 84 h following exposure to beams of accelerated 1H,...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01275215
更新日期:1995-06-01 00:00:00
abstract::The effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate (cAMP) in smooth muscle preparations from frog lung was studied. cAMP, given as dibutyryl salt (dib-cAMP) inhibited the radiation induced contractions of the muscle in a manner similar to the action of theophylline. In v...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323750
更新日期:1982-01-01 00:00:00
abstract::The biophysical characteristics of heavy ions make them a rational source of radiation for use in radiotherapy of malignant tumours. Prior to radiotherapy treatment, a therapeutic regimen must be precisely defined, and during this stage information on individual patient radiosensitivity would be of very great medical ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0063-2
更新日期:2006-11-01 00:00:00
abstract::137Cs from global fallout of nuclear weapon testings in the 1950s and 1960s was determined in successive layers (0-30 cm) of eight undisturbed grassland soils in Bavaria, Germany. The maximum activity concentration was found in soil layers between 4 and 15 cm below the surface. Using the vertical distribution of the c...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050088
更新日期:1998-04-01 00:00:00
abstract::Time-dependent yields of the most important products of water radiolysis E(aq)(-), (*)OH, H(*), H(3)O(+), H(2), OH(-) and H(2)O(2) have been calculated for (60)Co-photons, electrons, protons, helium- and carbon-ions incident onto water. G values have been evaluated for the interval from 1 ps to 1 mus after initial ene...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0194-8
更新日期:2009-02-01 00:00:00
abstract::The major part of the liquid radioactive waste released by the Mayak Production Association (PA) radiochemical plant into the Techa river occurred in 1949-1951, but there is information on only one single radiochemical analysis of a water sample taken on 24 and 25 September 1951. These data are here used to assess the...
journal_title:Radiation and environmental biophysics
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00411-003-0182-y
更新日期:2003-04-01 00:00:00
abstract::The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they we...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050149
更新日期:1999-07-01 00:00:00