Abstract：
:In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for the numerous genetic alterations of cancer cells. Most of them occur during tumor progression. Only one or a very limited number of them was induced by radiation many years before tumor growth. This long delay is a major difficulty for experimental research and raises many questions. Recently, it has been shown that a genomic instability occurs after many generations in cells descending from irradiated cells. This instability leads to multiple genetic alterations and, preferentially, affects some chromosome structures, particularly telomeres. This kind of telomeric instability - related to the shortening of telomeric DNA sequences - has also been observed in senescent cells as well as in non-senescent cells from patients predisposed to cancer, and this process may possibly also occur in the progeny of irradiated cells.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Sabatier L,Lebeau J,Dutrillaux Bdoi
10.1007/BF01209747subject
Has Abstractpub_date
1995-11-01 00:00:00pages
229-32issue
4eissn
0301-634Xissn
1432-2099journal_volume
34pub_type
杂志文章,评审abstract：:The radiation-induced process of strand breaks on pBR322 plasmid DNA in aqueous solution for different energy electrons was studied by Monte Carlo simulation. Assumptions of induction mechanisms of single- and double-strand breaks (SSBs and DSBs) used in the simulation are that SSB is induced by OH or H reaction with ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-002-0161-8
更新日期：2002-09-01 00:00:00
abstract：:The ion microprobe SNAKE at the Munich 14 MV tandem accelerator achieves beam focussing by a superconducting quadrupole doublet and can make use of a broad range of ions and ion energies, from 20 MeV protons to 200 MeV gold ions. Because of these properties, SNAKE is particularly attractive for biological microbeam ex...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-003-0222-7
更新日期：2004-02-01 00:00:00
abstract：:Ehrlich ascites tumour cells were irradiated with negative pions at different positions in the plateau and the peak of the depth absorbed dose curve. Dose-survival curves for immediate testing of the viability of the cells are given and are compared with other types of radiations in use for therapy. From the data obta...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01358286
更新日期：1979-08-10 00:00:00
abstract：:The effects of single pulses and multiple pulses of 7 MV electrons on micronuclei (MN) induction in cytokinesis-blocked human peripheral blood lymphocytes (PBLs) were investigated over a wide range of dose rates per pulse (instantaneous dose rate). PBLs were exposed to graded doses of 2, 3, 4, 6, and 8 Gy of single el...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-011-0353-1
更新日期：2011-05-01 00:00:00
abstract：:The sulphur-containing radioprotectors mercaptoethylamine (MEA), aminoethylisothiourea (AET), 2- aminothiazoline , 4-oxo-2- aminothiazoline , and S-S-3- oxapentane -1,5- diisothiourea , and the radioprotective biogenic amines serotonin, histamine, and dopamine, caused the elevation of cAMP content and intensified the ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01213732
更新日期：1984-01-01 00:00:00
abstract：:Our recent results suggest that 50 Hz magnetic fields (MF) enhance ultraviolet (UV)-induced tumorigenesis in mouse skin. The aim of the present experiment was to study suppression of apoptosis as a possible mechanism for MF effects on skin tumorigenesis. Another aim was to test the importance of a UV and MF exposure s...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-002-0153-8
更新日期：2002-06-01 00:00:00
abstract：:Procedures for age-adjustment of cancer fractions are proposed which do not require fixed age intervals. The full available information on survival times can then be used, which is especially important in small treatment groups. For incidental cancers a non-decreasing prevalence function and for fatal cancers the Kapl...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-004-0250-y
更新日期：2004-09-01 00:00:00
abstract：:The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with d...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-015-0600-y
更新日期：2015-08-01 00:00:00
abstract：:The kinetics of fluoresceindiacetate (FDA)-hydrolysis in erythrocytes, CHO-cells and homogenized cells was investigated by means of fluorescence spectroscopy. At a 10(-6)m FDA concentration the enzymatic conversion in the homogenized cells can be described by first order reactions. When studying intact cells, total ki...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01331024
更新日期：1977-04-27 00:00:00
abstract：:A method which allows growth of normal human tissue to be studied in vitro is used to investigate possible interactive effects of radiation and environmentally important carcinogens on oesophageal and urothelial cell growth. Carcinogens chosen were selected for their known or suspected effect on the oesophageal mucosa...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211257
更新日期：1989-01-01 00:00:00
abstract：:It is shown that the properties of ATPase (EC 3.6.1.3) of Micrococcus luteus depend only to some extent on the state of the membrane to which it is attached. Its interaction with the membrane appears to be largely controlled by polar forces. It is shown, however, that the UV-sensitivity of the membrane-bound ATPase is...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323619
更新日期：1976-03-30 00:00:00
abstract：:The naturally synchronous development of early mouse embryos was exploited to address the question, whether micronuclei require a mitosis for expression or whether they can be expressed in the same cell cycle, in which exposure to X-rays or caffeine took place. Experiments with 2-cell and with 4-cell embryos showed th...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01219345
更新日期：1991-01-01 00:00:00
abstract：:Within the Theory of Dual Radiation Action, the heuristically useful function, gamma(chi), that two energy depositions, a distance chi apart, will result in observable damage can be written in terms of two more fundamental quantities: One, s(chi), describes the structure of the sensitive matrix of the cell. The other,...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01210836
更新日期：1988-01-01 00:00:00
abstract：:The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they we...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050149
更新日期：1999-07-01 00:00:00
abstract：:Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01209769
更新日期：1993-01-01 00:00:00
abstract：:Radiological impact assessment for flora and fauna requires adequate dosimetric data. Due to the variability of habitats, shapes, and masses of the non-human biota, assessment of doses is a challenging task. External and internal dose conversion coefficients for photons and electrons have been systematically calculate...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0061-4
更新日期：2006-09-01 00:00:00
abstract：:A number of approaches have been proposed to estimate the exposure of non-human biota to ionizing radiation. This paper reports an inter-comparison of the unweighted absorbed dose rates for the whole organism (compared as dose conversion coefficients, or DCCs) for both internal and external exposure, estimated by 11 o...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-007-0124-1
更新日期：2007-11-01 00:00:00
abstract：:The majority of the public in industrial countries believes that pollution and low doses of radiation are threats to good health. As a matter of fact, when these putative risks are compared to those originating from lifestyle, they appear very small. In particular, the risks associated with low doses of irradiation, e...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/pl00007682
更新日期：2000-03-01 00:00:00
abstract：:Various transport models are presently used to predict the long-term migration behaviour of fallout radiocesium on the soil. To examine to what extent the uncertainty of these predictions is influenced by the spatial variability of the migration rates, we determined the depth profiles of Chernobyl-derived 137Cs at 100...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110000062
更新日期：2000-09-01 00:00:00
abstract：:Computational models of human anatomy are mathematical representations of human anatomy designed to be used in dosimetry calculations. They have been used in dosimetry calculations for radiography, radiotherapy, nuclear medicine, radiation protection and to investigate the effects of low frequency electromagnetic fiel...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/s00411-003-0221-8
更新日期：2004-02-01 00:00:00
abstract：:A Monte Carlo model is presented to study details of the energy deposition inside tracks of heavy charged particles in water vapor. The input data for most of the calculations based on the binary encounter approximation are double-differential cross sections for electron emission after heavy-ion impact. The paths of t...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/BF01219334
更新日期：1994-01-01 00:00:00
abstract：:In mice, persisting radiation-induced growth retardation of hematopoietic tissue suggested that at least part of the surviving stem cells are genetically injured. Additional mitotic stress some time after the radiation insult might remove injured stem cells, thus improving the overall recovery of the irradiated bone m...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211410
更新日期：1987-01-01 00:00:00
abstract：:Most of plutonium released by nuclear explosions is Pu-241 which decays to Am-241. We have studied the deposition of Pu-241 and Am-241 in lichens collected since 1958 in the central part of Sweden (62.3 degrees N, 12. 4 degrees E). Comparative studies with Pu-isotopes, Pu-239 + 240 and Pu-238 were also performed. In 1...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF02176794
更新日期：1978-10-12 00:00:00
abstract：:For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tiss...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-011-0371-z
更新日期：2011-08-01 00:00:00
abstract：:The potential of heavy ion therapy for clinical use in cancer therapy stems from the biological parameters of heavy charged particles and their precise dose localization. Biologically, carbon, neon, and other heavy ion beams (up to about silicon) are clinically useful in overcoming the radioresistance of hypoxic tumor...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,评审
doi：10.1007/BF01210545
更新日期：1995-03-01 00:00:00
abstract：:The macroscopic reaction of the mouse skin was used to derive RBE values for negative pi-Mesons. Hind limbs of mice were irradiated with pions or X-rays. The pions were produced by the 590 MeV accelerator of the Schweizerisches Institut für Nuklearforschung (SIN). Early reaction was assessed over a period of 6--30 day...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01358292
更新日期：1979-08-10 00:00:00
abstract：:Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章,meta分析
doi：10.1007/s00411-018-0770-5
更新日期：2019-03-01 00:00:00
abstract：:The effect of negative pions (peak and plateau), photons (140 kV and 29 MeV), and 20 MeV electrons on the proliferative capacity of Ehrlich ascites carcinoma cells was investigated. Proliferative survival curves plotted for the modalities employed are presented. Under the experimental conditions used, the peak pions w...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01358287
更新日期：1979-08-10 00:00:00
abstract：:A new device for the measurement of complete laser induced fluorescence emission spectra (maxima near 690 and 735 nm) of leaves during the induction of the chlorophyll fluorescence is described. In this the excitation light (cw He/Ne laser, 632.8 nm) is switched on by a fast electro-mechanical shutter which provides a...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01211213
更新日期：1992-01-01 00:00:00
abstract：:137Cs from global fallout of nuclear weapon testings in the 1950s and 1960s was determined in successive layers (0-30 cm) of eight undisturbed grassland soils in Bavaria, Germany. The maximum activity concentration was found in soil layers between 4 and 15 cm below the surface. Using the vertical distribution of the c...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050088
更新日期：1998-04-01 00:00:00
