Abstract:
:The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. (137)Cs content was measured in various organs, indicating that (137)Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although (137)Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Bertho JM,Louiba S,Faure MC,Tourlonias E,Stefani J,Siffert B,Paquet F,Dublineau Idoi
10.1007/s00411-010-0267-3subject
Has Abstractpub_date
2010-05-01 00:00:00pages
239-48issue
2eissn
0301-634Xissn
1432-2099journal_volume
49pub_type
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