Biodistribution of (137)Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system.

Abstract:

:The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. (137)Cs content was measured in various organs, indicating that (137)Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although (137)Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function.

journal_name

Radiat Environ Biophys

authors

Bertho JM,Louiba S,Faure MC,Tourlonias E,Stefani J,Siffert B,Paquet F,Dublineau I

doi

10.1007/s00411-010-0267-3

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

239-48

issue

2

eissn

0301-634X

issn

1432-2099

journal_volume

49

pub_type

杂志文章
  • Are cancer risks associated with exposures to ionising radiation from internal emitters greater than those in the Japanese A-bomb survivors?

    abstract::After ingestion or inhalation of radionuclides, internal organs of the human body will be exposed to ionising radiation. Current risk estimates of radiation-associated cancer from internal emitters are largely based on extrapolation of risk from high-dose externally exposed groups. Concerns have been expressed that ex...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00411-007-0122-3

    authors: Little MP,Hall P,Charles MW

    更新日期:2007-11-01 00:00:00

  • Repair of cellular radiation damage in space under microgravity conditions.

    abstract::The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54-3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they we...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110050149

    authors: Pross HD,Kiefer J

    更新日期:1999-07-01 00:00:00

  • Criteria of applicability for autoradiography of tritium.

    abstract::Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly quantitative, but it requires carefully controlled conditions and a ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01209769

    authors: Kellerer AM,Chen J,Roos H

    更新日期:1993-01-01 00:00:00

  • Radiobiological effects of total body irradiation on the spinal cord.

    abstract::Total body Irradiation (TBI) is often used for conditioning, prior to bone marrow transplantation. Doses of 8-14 Gy in 1-8 fractions over 1-4 days are administered using low dose rate external beam radiotherapy (EBRT). When necessary, consolidation EBRT using conventional doses, fractionation and dose rate is given. T...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-009-0238-8

    authors: Nevelsky A,Bar-Deroma R,Kuten A

    更新日期:2009-11-01 00:00:00

  • The influence of the channel size on the reduction of side effects in microchannel proton therapy.

    abstract::The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with d...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-015-0600-y

    authors: Girst S,Greubel C,Reindl J,Siebenwirth C,Zlobinskaya O,Dollinger G,Schmid TE

    更新日期:2015-08-01 00:00:00

  • Radiobiological data for clinical dosimetry in pion tumour therapy.

    abstract::Ehrlich ascites tumour cells were irradiated with negative pions at different positions in the plateau and the peak of the depth absorbed dose curve. Dose-survival curves for immediate testing of the viability of the cells are given and are compared with other types of radiations in use for therapy. From the data obta...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01358286

    authors: Heyder IR,Pohlit W

    更新日期:1979-08-10 00:00:00

  • Calculation on spectrum of direct DNA damage induced by low-energy electrons including dissociative electron attachment.

    abstract::In this work, direct DNA damage induced by low-energy electrons (sub-keV) is simulated using a Monte Carlo method. The characteristics of the present simulation are to consider the new mechanism of DNA damage due to dissociative electron attachment (DEA) and to allow determining damage to specific bases (i.e., adenine...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-016-0681-2

    authors: Liu W,Tan Z,Zhang L,Champion C

    更新日期:2017-03-01 00:00:00

  • Genetic mechanisms of formation of radiation-induced instability of the genome and its transgenerational effects in the descendants of chronically irradiated individuals of Drosophila melanogaster.

    abstract::The article is devoted to the study of the role of intracellular mechanisms in the formation of radiation-induced genetic instability and its transgenerational effect in cells of different tissues of the descendants of Drosophila melanogaster mutant strains whose parents were exposed to chronic radiation (0.42 and 3.5...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-020-00833-2

    authors: Yushkova E

    更新日期:2020-05-01 00:00:00

  • A method for determining weights for excess relative risk and excess absolute risk when applied in the calculation of lifetime risk of cancer from radiation exposure.

    abstract::Radiation-related risks of cancer can be transported from one population to another population at risk, for the purpose of calculating lifetime risks from radiation exposure. Transfer via excess relative risks (ERR) or excess absolute risks (EAR) or a mixture of both (i.e., from the life span study (LSS) of Japanese a...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0441-x

    authors: Walsh L,Schneider U

    更新日期:2013-03-01 00:00:00

  • DS02 fluence spectra for neutrons and gamma rays at Hiroshima and Nagasaki with fluence-to-kerma coefficients and transmission factors for sample measurements.

    abstract::Fluence spectra at several ground distances in Hiroshima and Nagasaki are provided along with associated fluence-to-kerma coefficients from the Dosimetry System 2002 (DS02). Also included are transmission factors for calculating expected responses of in situ sample measurements of neutron activation products such as (...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-007-0120-5

    authors: Egbert SD,Kerr GD,Cullings HM

    更新日期:2007-11-01 00:00:00

  • Changes in the cellularity of the cortex of human hairs as an indicator of radiation exposure.

    abstract::Growing hair follicles with their rapid cell proliferation would be expected to be sensitive organs to cytotoxic agents such as radiation. Various abnormalities in the hair and hair follicles have been reported in the past. Changes in the number of cells in the newly forming hair cortex have been shown in the mouse to...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF02434035

    authors: Potten CS,Burt PA,Roberts SA,Deshpande NA,Williams PC,Ramsden J

    更新日期:1996-05-01 00:00:00

  • Meta-analysis of case-control studies on the relationship between lung cancer and indoor radon exposure.

    abstract::Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00411-018-0770-5

    authors: Malinovsky G,Yarmoshenko I,Vasilyev A

    更新日期:2019-03-01 00:00:00

  • Effect of thiol reagents and ionizing radiation on the permeability of erythrocyte membrane for spin-labeled non-electrolytes.

    abstract::Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-o...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323760

    authors: Gwoździński K,Bartosz G,Leyko W

    更新日期:1983-01-01 00:00:00

  • Photochemically induced cross-links between DNA and alcohol dehydrogenase or salmine, respectively.

    abstract::Model experiments with two structurally different proteins (alcohol dehydrogenase and salmine) show that glycine, alanine, and tyrosine are by far more frequently involved in photochemically induced cross-link formations with DNA than is cysteine. The yields for cross-link formation of thymidine with salmine (cysteine...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01332171

    authors: Toth B,Dose K

    更新日期:1976-07-30 00:00:00

  • Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE).

    abstract::Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-003-0214-7

    authors: Langner I,Blettner M,Gundestrup M,Storm H,Aspholm R,Auvinen A,Pukkala E,Hammer GP,Zeeb H,Hrafnkelsson J,Rafnsson V,Tulinius H,De Angelis G,Verdecchia A,Haldorsen T,Tveten U,Eliasch H,Hammar N,Linnersjö A

    更新日期:2004-02-01 00:00:00

  • Time course solutions of the Sax-Markov binary eurejoining/misrejoining model of DNA double-strand breaks.

    abstract::The Sax-Markov binary eurejoining/misrejoining (SMBE) model is a stochastic representation of Sax's breakage-and-reunion mechanism of misrejoining DNA double-strand breaks (DSBs). In this model, to approximate DSB misrejoining probabilities that decrease with increasing distance, the nucleus is treated as a collection...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110000067

    authors: Radivoyevitch T

    更新日期:2000-12-01 00:00:00

  • Comparative study of G2 delay and survival after 241 Americium-alpha and 60cobalt-gamma irradiation.

    abstract::Survival and G2 dalay following exposure to either 60Cobalt-gamma-rays or 241Americium-alpha-particles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effec...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01325466

    authors: Lücke-Huhle C,Comper W,Hieber L,Pech M

    更新日期:1982-01-01 00:00:00

  • Survival of diploid yeast cells to bleomycin in combination with UV-light or hyperthermia.

    abstract::In the present work we have investigated the possible interaction between Bleomycin (B) and UV light or hyperthermia (HT) in the induction of lethal events in diploid yeast populations in the stationary phase of growth. UV and B acting as single agents determine sigmoid survival curves. The combination of UV + B produ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01219348

    authors: Barrios E,Candreva EC,Nunes E

    更新日期:1991-01-01 00:00:00

  • Influence of stable iodine on the transfer of 131I into cows' milk.

    abstract::The effect of supplying three different stable iodine levels (about 70, 80, and 160 mg day-1) in the daily feed of four dairy cows has been studied for the excretion pattern of 131I. None of the different treatments had a statistically significant effect. A mean milk transfer coefficient of 0.015 +/- 0.001 d l-1 was d...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01212680

    authors: Voigt G,Schotola C,Probstmeier G,Röhrmoser G

    更新日期:1994-01-01 00:00:00

  • Reference man for radiological protection: 71 chemical elements' content of the prostate gland (normal and cancerous).

    abstract::Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-020-00884-5

    authors: Zaichick V,Wynchank S

    更新日期:2021-01-02 00:00:00

  • Intercomparison study on (152)Eu gamma ray and (36)Cl AMS measurements for development of the new Hiroshima-Nagasaki Atomic Bomb Dosimetry System 2002 (DS02).

    abstract::In the process of developing a new dosimetry system for atomic bomb survivors in Hiroshima and Nagasaki (DS02), an intercomparison study between (152)Eu and (36)Cl measurements was proposed, to reconcile the discrepancy previously observed in the Hiroshima data between measurements and calculations of thermal neutron ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-008-0166-z

    authors: Hoshi M,Endo S,Tanaka K,Ishikawa M,Straume T,Komura K,Rühm W,Nolte E,Huber T,Nagashima Y,Seki R,Sasa K,Sueki K,Fukushima H,Egbert SD,Imanaka T

    更新日期:2008-07-01 00:00:00

  • Absorption, retention and tissue distribution of radiocaesium in reindeer: effects of diet and radiocaesium source.

    abstract::Radiocaesium absorption and retention in reindeer (Rangifer tarandus) calves was compared in groups fed diets containing different proportions of lichen and concentrates, and different chemical forms of radiocaesium ((134)CsCl in solution or fallout from the Chernobyl accident). Daily intakes of fallout radiocaesium w...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-004-0257-4

    authors: Skuterud L,Pedersen Ø,Staaland H,Røed KH,Salbu B,Liken A,Hove K

    更新日期:2004-12-01 00:00:00

  • Residual radiation effect in the murine spleen. In situ measurement by 125-iodo-deoxyuridine retention.

    abstract::To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01325468

    authors: Hübner GE,von Wangenheim KH,Feinendegen LE

    更新日期:1982-01-01 00:00:00

  • Interaction of smoking and radon in rats: a biologically based mechanistic model.

    abstract::Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acti...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-005-0006-3

    authors: Heidenreich WF,Morlier JP,Monchaux G

    更新日期:2005-10-01 00:00:00

  • Effects of mixed neutron-gamma irradiation in vivo on the cell surfaces of murine blood cells.

    abstract::For studies on cell membranes, mice were exposed to mixed neutron + gamma reactor-radiation in the range of total doses from 0.5 to 4.5 Gy. Changes in functional activity of plasma membranes of erythrocytes, platelets, and lymphocytes were followed by a lectin-binding technique at various intervals afterwards. The amo...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01407598

    authors: Kubasova T,Antal S,Somosy Z,Köteles GJ

    更新日期:1984-01-01 00:00:00

  • Confocal microscopy for modeling electron microbeam irradiation of skin.

    abstract::For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tiss...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-011-0371-z

    authors: Miller JH,Chrisler WB,Wang X,Sowa MB

    更新日期:2011-08-01 00:00:00

  • Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study.

    abstract::Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose f...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-019-00819-9

    authors: Schöllnberger H,Kaiser JC,Eidemüller M,Zablotska LB

    更新日期:2020-03-01 00:00:00

  • Oxygenation of malignant tumors after localized microwave hyperthermia.

    abstract::The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation r...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323754

    authors: Vaupel PW,Otte J,Manz R

    更新日期:1982-01-01 00:00:00

  • Gamma-ray spectrometry of humans at the University of Utah.

    abstract::A human total-body counter was designed and built with two 20 X 10 cm NaI (Tl) crystals suspended over an "isoresponse surface" upon which the subject reclines. This surface is curved from head to knee and from left to right, so that a gamma-ray emitting object is detected with equal efficiency when placed anywhere up...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323223

    authors: Lloyd RD,Mays CW,Taysum DH

    更新日期:1979-04-30 00:00:00

  • Results of heavy ion radiotherapy.

    abstract::The potential of heavy ion therapy for clinical use in cancer therapy stems from the biological parameters of heavy charged particles and their precise dose localization. Biologically, carbon, neon, and other heavy ion beams (up to about silicon) are clinically useful in overcoming the radioresistance of hypoxic tumor...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01210545

    authors: Castro JR

    更新日期:1995-03-01 00:00:00