Genetic mechanisms of formation of radiation-induced instability of the genome and its transgenerational effects in the descendants of chronically irradiated individuals of Drosophila melanogaster.

Abstract:

:The article is devoted to the study of the role of intracellular mechanisms in the formation of radiation-induced genetic instability and its transgenerational effect in cells of different tissues of the descendants of Drosophila melanogaster mutant strains whose parents were exposed to chronic radiation (0.42 and 3.5 mGy/h). The level of DNA damage (alkali-labile sites (ALS), single-strand (SSB) and double-strand (DSB) breaks) in cells of somatic (nerve ganglia, imaginal discs) and generative (testis) tissues from directly irradiated animals and their unirradiated offspring was evaluated. Confident transgenerational instability (on the level of ALSs and SSBs), observed only in somatic tissues and only at the higher dose rate, is characteristic for mus209 mutant strains defective in excision repair and, less often, for mus205 and mus210 mutant strains. The greatest manifestation of radiation-induced genetic instability was found in evaluating the DSBs. Dysfunction of the genes mus205, mus304, mei-9 and mei-41, which are responsible for postreplicative repair, excision repair, recombination and control of the cell cycle, affects transgenerational changes in the somatic tissues of the offspring of parents irradiated in both low and high dose rates. In germ cells, the key role in maintaining genetic stability under chronic irradiation is played by the non-recombination postreplication repair mus101 gene. We revealed the tissue specificity of the radiation-induced effects, transgenerational transmission and accumulation of DNA damage to descendants of chronically irradiated animals.

journal_name

Radiat Environ Biophys

authors

Yushkova E

doi

10.1007/s00411-020-00833-2

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

221-236

issue

2

eissn

0301-634X

issn

1432-2099

pii

10.1007/s00411-020-00833-2

journal_volume

59

pub_type

杂志文章
  • Influence of stable iodine on the transfer of 131I into cows' milk.

    abstract::The effect of supplying three different stable iodine levels (about 70, 80, and 160 mg day-1) in the daily feed of four dairy cows has been studied for the excretion pattern of 131I. None of the different treatments had a statistically significant effect. A mean milk transfer coefficient of 0.015 +/- 0.001 d l-1 was d...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01212680

    authors: Voigt G,Schotola C,Probstmeier G,Röhrmoser G

    更新日期:1994-01-01 00:00:00

  • Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions.

    abstract::The aim of this interdisciplinary project is to establish slice culture preparations from rodents and humans as a new model system for studying effects of X-rays and heavy ions within normal and tumor tissues. The advantage of such slice cultures relies on the conservation of an organotypic environment, the easy treat...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-010-0293-1

    authors: Merz F,Müller M,Taucher-Scholz G,Rödel F,Stöcker H,Schopow K,Laprell L,Dehghani F,Durante M,Bechmann I

    更新日期:2010-08-01 00:00:00

  • ROS release and Hsp70 expression after exposure to 1,800 MHz radiofrequency electromagnetic fields in primary human monocytes and lymphocytes.

    abstract::The aim of this study is to investigate if 1,800 MHz radiofrequency electromagnetic fields (RF-EMF) can induce reactive oxygen species (ROS) release and/or changes in heat shock protein 70 (Hsp70) expression in human blood cells, using different exposure and co-exposure conditions. Human umbilical cord blood-derived m...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-006-0038-3

    authors: Lantow M,Lupke M,Frahm J,Mattsson MO,Kuster N,Simko M

    更新日期:2006-05-01 00:00:00

  • Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.

    abstract::The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various param...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0410-4

    authors: Schöllnberger H,Kaiser JC,Jacob P,Walsh L

    更新日期:2012-05-01 00:00:00

  • Effects of lithium chloride as a potential radioprotective agent on radiation response of DNA synthesis in mouse germinal cells.

    abstract::Mouse spermatogonial germ cells are highly sensitive to ionizing radiation. Lithium salts are reported to stimulate the postirradiation recovery of hematopoietic marrow cells. We have, therefore, examined whether administered lithium chloride (LiCl) would also be able to protect the mouse germinal cells against radiat...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s004110050063

    authors: Bhattacharjee D,Rajan R,Krishnamoorthy L,Singh BB

    更新日期:1997-06-01 00:00:00

  • Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE).

    abstract::Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-003-0214-7

    authors: Langner I,Blettner M,Gundestrup M,Storm H,Aspholm R,Auvinen A,Pukkala E,Hammer GP,Zeeb H,Hrafnkelsson J,Rafnsson V,Tulinius H,De Angelis G,Verdecchia A,Haldorsen T,Tveten U,Eliasch H,Hammar N,Linnersjö A

    更新日期:2004-02-01 00:00:00

  • Genetic effect of low doses of radiation in occupationally exposed workers in coal mines and in coal fired plants.

    abstract::Analyses of structural aberrations of chromosomes and of the body burden of lead-210 were carried out in a group of workers occupationally exposed to chemical pollutants and low doses of ionizing radiation during a technological process in which coal is used as fuel. A parallel study was performed in a control group o...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01326048

    authors: Horvat D,Bauman A,Racić J

    更新日期:1980-01-01 00:00:00

  • Temperature dependent modification of radiosensitivity following hypoxic cytocidal action of chlorpromazine.

    abstract::The hypoxic cytotoxic effect of chlorpromazine towards E. coli B/r was observed to be dependent on temperature of incubation and irradiation. Increasing the temperature of incubation from ambient to 37 degrees C followed by irradiation revealed that the organisms showed radiosensitivity of a magnitude which was two to...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01229816

    authors: Shenoy MA,Singh BB

    更新日期:1985-01-01 00:00:00

  • NOREC, a Monte Carlo code for simulating electron tracks in liquid water.

    abstract::The work reported here was originally motivated by a discussion of Monte Carlo computer codes for electron transport in water given in Report No. 130 by the National Council on Radiation Protection and Measurements (NCRP). It was pointed out (correctly) that a published depth-dose distribution calculated by the Oak Ri...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-003-0201-z

    authors: Semenenko VA,Turner JE,Borak TB

    更新日期:2003-10-01 00:00:00

  • Temporarily increased TGFβ following radon spa correlates with reduced pain while serum IL-18 is a general predictive marker for pain sensitivity.

    abstract::Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...

    journal_title:Radiation and environmental biophysics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00411-018-0768-z

    authors: Kullmann M,Rühle PF,Harrer A,Donaubauer A,Becker I,Sieber R,Klein G,Fournier C,Fietkau R,Gaipl US,Frey B

    更新日期:2019-03-01 00:00:00

  • Radionuclide transfer to marine biota species: review of Russian language studies.

    abstract::An extensive programme of experiments on transfer of radionuclides to aquatic species was conducted in the former USSR starting from the early 1950s. Only a few of these studies were made available in the English language literature or taken into account in international reviews of radionuclide behaviour in marine eco...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-010-0324-y

    authors: Fesenko S,Fesenko E,Titov I,Karpenko E,Sanzharova N,Fonseca AG,Brown J

    更新日期:2010-11-01 00:00:00

  • Effect of negative pions, relative to 140 kV -- 29 MeV photons and 20 MeV electrons, on proliferation of Ehrlich ascites carcinoma cells.

    abstract::The effect of negative pions (peak and plateau), photons (140 kV and 29 MeV), and 20 MeV electrons on the proliferative capacity of Ehrlich ascites carcinoma cells was investigated. Proliferative survival curves plotted for the modalities employed are presented. Under the experimental conditions used, the peak pions w...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01358287

    authors: Rao KR,Blattmann H,Cordt I,Fritz-Niggli H

    更新日期:1979-08-10 00:00:00

  • The influence of the channel size on the reduction of side effects in microchannel proton therapy.

    abstract::The potential of proton microchannel radiotherapy to reduce radiation effects in the healthy tissue but to keep tumor control the same as in conventional proton therapy is further elucidated. The microchannels spread on their way to the tumor tissue resulting in different fractions of the healthy tissue covered with d...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-015-0600-y

    authors: Girst S,Greubel C,Reindl J,Siebenwirth C,Zlobinskaya O,Dollinger G,Schmid TE

    更新日期:2015-08-01 00:00:00

  • Neutron relative biological effectiveness for solid cancer incidence in the Japanese A-bomb survivors: an analysis considering the degree of independent effects from γ-ray and neutron absorbed doses with hierarchical partitioning.

    abstract::It has generally been assumed that the neutron and γ-ray absorbed doses in the data from the life span study (LSS) of the Japanese A-bomb survivors are too highly correlated for an independent separation of the all solid cancer risks due to neutrons and due to γ-rays. However, with the release of the most recent data ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0445-6

    authors: Walsh L

    更新日期:2013-03-01 00:00:00

  • Enhanced proliferation of cells from human tissue explants following irradiation in the presence of environmental carcinogens.

    abstract::A method which allows growth of normal human tissue to be studied in vitro is used to investigate possible interactive effects of radiation and environmentally important carcinogens on oesophageal and urothelial cell growth. Carcinogens chosen were selected for their known or suspected effect on the oesophageal mucosa...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01211257

    authors: Mothersill C,Cusack A,Seymour CB

    更新日期:1989-01-01 00:00:00

  • The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats.

    abstract::The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01210512

    authors: Trnovec T,Volenec K,Bezek S,Kállay Z,Durisová M,Scasnár V,Kubu M,Svoboda V

    更新日期:1991-01-01 00:00:00

  • p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields.

    abstract::Our recent results suggest that 50 Hz magnetic fields (MF) enhance ultraviolet (UV)-induced tumorigenesis in mouse skin. The aim of the present experiment was to study suppression of apoptosis as a possible mechanism for MF effects on skin tumorigenesis. Another aim was to test the importance of a UV and MF exposure s...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-002-0153-8

    authors: Kumlin T,Heikkinen P,Kosma VM,Alhonen L,Jänne J,Juutilainen J

    更新日期:2002-06-01 00:00:00

  • Ionizing radiation-induced structural modification of human red blood cells.

    abstract::The effect of gamma radiation on red blood cells have been examined using a spin labeling method. For this purpose two spin labels were used to monitor membrane fluidity: methyl 5-doxylpalmitate (Met 5-DP) and methyl 12-doxylstearate (Met 12-DS). The irradiation of red cells with the doses of 200 and 500 Gy caused dec...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01595573

    authors: Gwoździński K

    更新日期:1991-01-01 00:00:00

  • Photoproducts generated from hematoporphyrin under high-intensity picosecond flash photolysis. Evidences for involvement of biophotonic processes.

    abstract::Hematoporphyrin (Hp) solutions were subjected to a wide range high intensity (0.2-10.0 GW/cm2) near-UV laser pulse radiation (lambda exc = 355 nm, pulse duration 30 ps). The formation of stable Hp photoproducts was followed by UV-VIS absorption spectroscopy and liquid-gel column chromatography. As judged by the influe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01210525

    authors: Gantchev T,Keskinova E,Kaltchev M,Angelov D

    更新日期:1990-01-01 00:00:00

  • Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle irradiated mice.

    abstract::Osteosarcoma is the most frequent secondary malignancy following radiotherapy of patients with bilateral retinoblastoma. This suggests that the Rb1 tumour suppressor gene might confer genetic susceptibility towards radiation-induced osteosarcoma. To define the contribution of the Rb1 pathway in the multistep process o...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-010-0339-4

    authors: Gonzalez-Vasconcellos I,Domke T,Kuosaite V,Esposito I,Sanli-Bonazzi B,Nathrath M,Atkinson MJ,Rosemann M

    更新日期:2011-03-01 00:00:00

  • Meta-analysis of case-control studies on the relationship between lung cancer and indoor radon exposure.

    abstract::Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00411-018-0770-5

    authors: Malinovsky G,Yarmoshenko I,Vasilyev A

    更新日期:2019-03-01 00:00:00

  • Beam delivery systems for charged particles.

    abstract::Heavy charged particle therapy, started at research institutes three decades ago, is now on the verge of entering a clinical phase. This phase has resulted from the evolution and development of various beam delivery systems and techniques with existing research accelerators and with newly built accelerators. For the f...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/BF01214829

    authors: Blattmann H

    更新日期:1992-01-01 00:00:00

  • A method for determining weights for excess relative risk and excess absolute risk when applied in the calculation of lifetime risk of cancer from radiation exposure.

    abstract::Radiation-related risks of cancer can be transported from one population to another population at risk, for the purpose of calculating lifetime risks from radiation exposure. Transfer via excess relative risks (ERR) or excess absolute risks (EAR) or a mixture of both (i.e., from the life span study (LSS) of Japanese a...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-012-0441-x

    authors: Walsh L,Schneider U

    更新日期:2013-03-01 00:00:00

  • On the mechanism of 60-Hz electric field induced effects in Pisum sativum L. roots: vertical field exposures.

    abstract::Roots of Pisum sativum L. were chronically exposed to 60-Hz vertical electric fields ranging from 150 to 450V/m in an aqueous medium whose conductivity was approximately 0.07 S/m. Control and exposed roots were grown concomitantly in the same tank whose medium was continuously circulated and maintained at 19 degrees C...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323679

    authors: Miller MW,Dooley DA,Cox C,Carstensen EL

    更新日期:1983-01-01 00:00:00

  • The effects of simulating a realistic eye model on the eye dose of an adult male undergoing head computed tomography.

    abstract::In head computed tomography, radiation upon the eye lens (as an organ with high radiosensitivity) may cause lenticular opacity and cataracts. Therefore, quantitative dose assessment due to exposure of the eye lens and surrounding tissue is a matter of concern. For this purpose, an accurate eye model with realistic geo...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/s00411-017-0686-5

    authors: Akhlaghi P,Ebrahimi-Khankook A,Vejdani-Noghreiyan A

    更新日期:2017-05-01 00:00:00

  • The action of ionizing radiation on DNA in the presence of quinacrine. I. UV absorption and fluorescence measurements.

    abstract::It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF02339804

    authors: Hissung A,Dertinger H,Heinrich G

    更新日期:1975-06-13 00:00:00

  • A comparative kinetic study on the conversion of fluoresceindiacetate to fluorescein in living cells and in vitro.

    abstract::The kinetics of fluoresceindiacetate (FDA)-hydrolysis in erythrocytes, CHO-cells and homogenized cells was investigated by means of fluorescence spectroscopy. At a 10(-6)m FDA concentration the enzymatic conversion in the homogenized cells can be described by first order reactions. When studying intact cells, total ki...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01331024

    authors: Sontag W

    更新日期:1977-04-27 00:00:00

  • Studies on incorporated short-lived beta-emitters with regard to the induction of late effects.

    abstract::The rare earth radionuclides 177 Lu and 153Sm were administered as single i.p. injections in NMRI mice. Lu was deposited principally (up to 60%) in the skeleton if the quantity of stable carrier was low. Increase of stable carrier enhanced deposition in the reticulo-endothelial system. Sm was preferentially deposited ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01324368

    authors: Müller WA,Scháffer EH,Linzner U

    更新日期:1980-01-01 00:00:00

  • Effects of sparsely and densely ionizing radiation on plants.

    abstract::One of the main purposes leading botanists to investigate the effects of ionizing radiations is to understand plant behaviour in space, where vegetal systems play an important role for nourishment, psychological support and functioning of life support systems. Ground-based experiments have been performed with particle...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s00411-010-0343-8

    authors: De Micco V,Arena C,Pignalosa D,Durante M

    更新日期:2011-03-01 00:00:00

  • Oxygenation of malignant tumors after localized microwave hyperthermia.

    abstract::The oxyhemoglobin saturation (HbO2) of single red blood cells within tumor microvessels (diameter: 3-12 micrometers) of DS-Carcinosarcoma was studied using a cryophotometric micromethod. In untreated control tumors (mean tissue temperature approx. 35 degrees C) the measured values scattered over the whole saturation r...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章

    doi:10.1007/BF01323754

    authors: Vaupel PW,Otte J,Manz R

    更新日期:1982-01-01 00:00:00