Abstract:
:The article is devoted to the study of the role of intracellular mechanisms in the formation of radiation-induced genetic instability and its transgenerational effect in cells of different tissues of the descendants of Drosophila melanogaster mutant strains whose parents were exposed to chronic radiation (0.42 and 3.5 mGy/h). The level of DNA damage (alkali-labile sites (ALS), single-strand (SSB) and double-strand (DSB) breaks) in cells of somatic (nerve ganglia, imaginal discs) and generative (testis) tissues from directly irradiated animals and their unirradiated offspring was evaluated. Confident transgenerational instability (on the level of ALSs and SSBs), observed only in somatic tissues and only at the higher dose rate, is characteristic for mus209 mutant strains defective in excision repair and, less often, for mus205 and mus210 mutant strains. The greatest manifestation of radiation-induced genetic instability was found in evaluating the DSBs. Dysfunction of the genes mus205, mus304, mei-9 and mei-41, which are responsible for postreplicative repair, excision repair, recombination and control of the cell cycle, affects transgenerational changes in the somatic tissues of the offspring of parents irradiated in both low and high dose rates. In germ cells, the key role in maintaining genetic stability under chronic irradiation is played by the non-recombination postreplication repair mus101 gene. We revealed the tissue specificity of the radiation-induced effects, transgenerational transmission and accumulation of DNA damage to descendants of chronically irradiated animals.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Yushkova Edoi
10.1007/s00411-020-00833-2subject
Has Abstractpub_date
2020-05-01 00:00:00pages
221-236issue
2eissn
0301-634Xissn
1432-2099pii
10.1007/s00411-020-00833-2journal_volume
59pub_type
杂志文章abstract::Native horseradish peroxidase, as well as its reduced and carboxymethylated form, and the apoenzyme, showed resistance to photodynamic action. Sensitivity to this action was detected only in reduced and carboxymethylated apoenzyme, when the photooxidation of its histidine residues was observed. When analyzing the bulk...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01212653
更新日期:1985-01-01 00:00:00
abstract::The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three radionuclides to sheep...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050078
更新日期:1998-02-01 00:00:00
abstract::The effect of ionizing irradiation on the physiological activity of cyclic adenosine monophosphate (cAMP) in smooth muscle preparations from frog lung was studied. cAMP, given as dibutyryl salt (dib-cAMP) inhibited the radiation induced contractions of the muscle in a manner similar to the action of theophylline. In v...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323750
更新日期:1982-01-01 00:00:00
abstract::The Goiânia accident, Brazil, was used as an opportunity to quantify the contributions of different mechanisms, in particular mass loading, leading to caesium uptake by leafy vegetables in a semi-urban environment contaminated with 137Cs. Soil splash contributions of 70-90% were quantified for lettuce and 50-60% for g...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01210458
更新日期:1994-01-01 00:00:00
abstract::Our recent results suggest that 50 Hz magnetic fields (MF) enhance ultraviolet (UV)-induced tumorigenesis in mouse skin. The aim of the present experiment was to study suppression of apoptosis as a possible mechanism for MF effects on skin tumorigenesis. Another aim was to test the importance of a UV and MF exposure s...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-002-0153-8
更新日期:2002-06-01 00:00:00
abstract::The main target of this work is to examine blood clearance and external exposure for 177Lu-DOTATATE compared with new emerging 177Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq 177Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq 177Lu-PSMA. Dose ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0721-6
更新日期:2018-03-01 00:00:00
abstract::Simple, ellipsoidal geometries have long been the standard for estimating radiation dose rates in non-human biota (NHB). With the introduction of a regulatory protection standard that emphasizes protection of NHB as its own end point, there has been interest in improved models for the calculation of dose rates in NHB....
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-014-0546-5
更新日期:2014-08-01 00:00:00
abstract::Cosmic radiation is an occupational risk factor for commercial aircrews. In this large European cohort study (ESCAPE) its association with cancer mortality was investigated on the basis of individual effective dose estimates for 19,184 male pilots. Mean annual doses were in the range of 2-5 mSv and cumulative lifetime...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-003-0214-7
更新日期:2004-02-01 00:00:00
abstract::Quantitative cancer incidence data exist for various laboratory animal models, but little of this information is usable for estimating human risks, primarily because of uncertainties about possible mechanistic differences among species. Acceptance and utilization of animal data for human risk assessment will require a...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-007-0106-3
更新日期:2007-06-01 00:00:00
abstract::Among the various methods for studying the relative effects of transmutation and radiation of incorporated nuclides, simulation of beta radiation by external gamma exposure is of practical importance. Self-irradiation and mutual irradiation of the labeled cells cannot be neglected in any case. Furthermore, additional ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01326755
更新日期:1975-01-01 00:00:00
abstract::Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0728-z
更新日期:2018-05-01 00:00:00
abstract::Non-linear mechanical response of viscoelastic strain responding media to high amplitude stress-strain is examined from a phenomenological point of view and found to lead to results compatible with empirical observations of high intensity ultrasound irradiation of brain, liver, and eye lens tissues. The proposed hyste...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01324230
更新日期:1981-01-01 00:00:00
abstract::In this pilot study we compared for the first time the radiation sensitivity of mouse lens epithelial cells (LECs) and mouse lymphocytes. We freshly prepared LECs and lymphocytes and irradiated them with γ-rays ((137)Cs; doses ranging from 0.25 to 2 Gy). DNA damage and repair were evaluated by alkaline comet assay and...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-012-0451-8
更新日期:2013-05-01 00:00:00
abstract::Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR)...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,meta分析
doi:10.1007/s00411-018-0770-5
更新日期:2019-03-01 00:00:00
abstract::This study was undertaken to investigate the mechanism of chemical radiosensitization by halogenated bases incorporated into DNA. Radiation-induced base and sugar-phosphate backbone damage to 5-bromouridine-5'-monophosphate (5-BrUMP) was monitored using a flow system connected in series with a recording spectrophotome...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01211508
更新日期:1992-01-01 00:00:00
abstract::The aim of this study was to verify whether extremely low frequency (ELF) magnetic fields (MF) could affect transposition activity like some environmental stress factors such as heat shock or UV irradiation. Using an Escherichia coli Lac Z(-) strain transformed with a plasmid containing a Tn 10 derivative element expr...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-003-0192-9
更新日期:2003-07-01 00:00:00
abstract::During anthropogenic activities, such as agricultural soil management and traffic on unpaved roads, size distribution measurements were performed of atmospheric particulate radionuclides at a site in the Chernobyl 30-km exclusion zone. Analysis of cascade impactor measurements showed an increase of the total atmospher...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110050118
更新日期:1998-10-01 00:00:00
abstract::In head computed tomography, radiation upon the eye lens (as an organ with high radiosensitivity) may cause lenticular opacity and cataracts. Therefore, quantitative dose assessment due to exposure of the eye lens and surrounding tissue is a matter of concern. For this purpose, an accurate eye model with realistic geo...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-017-0686-5
更新日期:2017-05-01 00:00:00
abstract::The hypoxic cytotoxic effect of chlorpromazine towards E. coli B/r was observed to be dependent on temperature of incubation and irradiation. Increasing the temperature of incubation from ambient to 37 degrees C followed by irradiation revealed that the organisms showed radiosensitivity of a magnitude which was two to...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01229816
更新日期:1985-01-01 00:00:00
abstract::Many experimental studies are carried out to compare biological effectiveness of high dose rate (HDR) with that of low dose rate (LDR). The rational for this is the uncertainty regarding the value of the dose rate effectiveness factor (DREF) used in radiological protection. While a LDR is defined as 0.1 mGy/min or low...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-020-00852-z
更新日期:2020-08-01 00:00:00
abstract::To evaluate the dose distributions of an electron microbeam and to help optimization of its design, the condensed-history (CH) Monte Carlo simulation algorithm implemented in the Geant4 toolkit was selected as an alternative to the conventionally used analog algorithm. Compared to the analog algorithm, the CH algorith...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-006-0027-6
更新日期:2006-03-01 00:00:00
abstract::At five stages of gestation, mice were exposed dorsally to ultrasonic irradiation at 1 W/cm2 (spatial and temporal average), 2 MHz, and 34 and 37 degrees C (temperature at beginning of exposure). The results indicated that ultrasonic exposure up to at least 100 s is not hazardous to a pregnant mouse or its offspring i...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01323651
更新日期:1980-01-01 00:00:00
abstract::The Auger electron emitter 123I was examined in the form of 4-[123I]iodoantipyrine and as [123I]NaI for its effectiveness in killing cells of different sensitivity to photon irradiation. Micronucleus assays showed that 4-[123I]iodoantipyrine is 2-3 times more effective in cell inactivation than [123I]NaI. This can be ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s004110000083
更新日期:2001-03-01 00:00:00
abstract::It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently ...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF02339804
更新日期:1975-06-13 00:00:00
abstract::Testing the limits of survivability in space is the primary focus in astrobiological research. Although a number of previous studies have examined terrestrial life survival in an extraterrestrial environment, only a few have investigated how life systems respond to high doses of alpha cosmic ray, the main component of...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-019-00803-3
更新日期:2019-08-01 00:00:00
abstract::The lethal effects of high-voltage capacitor-discharges in suspensions of E. coli K12 with varying electrolytes have been examined. A reduction of more than 99.9% of living cells, dependent on the applied voltage could be proved. The bactericidal action is assumed to be due to direct effects of high electric fields. E...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01324271
更新日期:1980-01-01 00:00:00
abstract::The risk of cancer after diagnostic X-rays received as fetus or during early childhood has been investigated in many studies. The results of recent epidemiological studies are summarized in a present systematic review. The strategies for literature search, inclusion criteria, and items for study quality assessment wer...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-008-0171-2
更新日期:2008-07-01 00:00:00
abstract::Time-dependent yields of the most important products of water radiolysis E(aq)(-), (*)OH, H(*), H(3)O(+), H(2), OH(-) and H(2)O(2) have been calculated for (60)Co-photons, electrons, protons, helium- and carbon-ions incident onto water. G values have been evaluated for the interval from 1 ps to 1 mus after initial ene...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/s00411-008-0194-8
更新日期:2009-02-01 00:00:00
abstract::One of the main purposes leading botanists to investigate the effects of ionizing radiations is to understand plant behaviour in space, where vegetal systems play an important role for nourishment, psychological support and functioning of life support systems. Ground-based experiments have been performed with particle...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章,评审
doi:10.1007/s00411-010-0343-8
更新日期:2011-03-01 00:00:00
abstract::Estimates are presented on the carbon-14 generation rates in several reactor types and in peaceful nuclear explosions. If the carbon-14 generated in light water reactors is released, the population radiation dose rate it causes initially will be comparable to that resulting from the krypton-85 and tritium generated in...
journal_title:Radiation and environmental biophysics
pub_type: 杂志文章
doi:10.1007/BF01331176
更新日期:1976-12-23 00:00:00