Genetic mechanisms of formation of radiation-induced instability of the genome and its transgenerational effects in the descendants of chronically irradiated individuals of Drosophila melanogaster.


:The article is devoted to the study of the role of intracellular mechanisms in the formation of radiation-induced genetic instability and its transgenerational effect in cells of different tissues of the descendants of Drosophila melanogaster mutant strains whose parents were exposed to chronic radiation (0.42 and 3.5 mGy/h). The level of DNA damage (alkali-labile sites (ALS), single-strand (SSB) and double-strand (DSB) breaks) in cells of somatic (nerve ganglia, imaginal discs) and generative (testis) tissues from directly irradiated animals and their unirradiated offspring was evaluated. Confident transgenerational instability (on the level of ALSs and SSBs), observed only in somatic tissues and only at the higher dose rate, is characteristic for mus209 mutant strains defective in excision repair and, less often, for mus205 and mus210 mutant strains. The greatest manifestation of radiation-induced genetic instability was found in evaluating the DSBs. Dysfunction of the genes mus205, mus304, mei-9 and mei-41, which are responsible for postreplicative repair, excision repair, recombination and control of the cell cycle, affects transgenerational changes in the somatic tissues of the offspring of parents irradiated in both low and high dose rates. In germ cells, the key role in maintaining genetic stability under chronic irradiation is played by the non-recombination postreplication repair mus101 gene. We revealed the tissue specificity of the radiation-induced effects, transgenerational transmission and accumulation of DNA damage to descendants of chronically irradiated animals.


Radiat Environ Biophys


Yushkova E




Has Abstract


2020-05-01 00:00:00














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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Voigt G,Schotola C,Probstmeier G,Röhrmoser G

    更新日期:1994-01-01 00:00:00

  • Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions.

    abstract::The aim of this interdisciplinary project is to establish slice culture preparations from rodents and humans as a new model system for studying effects of X-rays and heavy ions within normal and tumor tissues. The advantage of such slice cultures relies on the conservation of an organotypic environment, the easy treat...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Merz F,Müller M,Taucher-Scholz G,Rödel F,Stöcker H,Schopow K,Laprell L,Dehghani F,Durante M,Bechmann I

    更新日期:2010-08-01 00:00:00

  • ROS release and Hsp70 expression after exposure to 1,800 MHz radiofrequency electromagnetic fields in primary human monocytes and lymphocytes.

    abstract::The aim of this study is to investigate if 1,800 MHz radiofrequency electromagnetic fields (RF-EMF) can induce reactive oxygen species (ROS) release and/or changes in heat shock protein 70 (Hsp70) expression in human blood cells, using different exposure and co-exposure conditions. Human umbilical cord blood-derived m...

    journal_title:Radiation and environmental biophysics

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    authors: Lantow M,Lupke M,Frahm J,Mattsson MO,Kuster N,Simko M

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  • Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.

    abstract::The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various param...

    journal_title:Radiation and environmental biophysics

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    authors: Schöllnberger H,Kaiser JC,Jacob P,Walsh L

    更新日期:2012-05-01 00:00:00

  • Effects of lithium chloride as a potential radioprotective agent on radiation response of DNA synthesis in mouse germinal cells.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Bhattacharjee D,Rajan R,Krishnamoorthy L,Singh BB

    更新日期:1997-06-01 00:00:00

  • Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE).

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Langner I,Blettner M,Gundestrup M,Storm H,Aspholm R,Auvinen A,Pukkala E,Hammer GP,Zeeb H,Hrafnkelsson J,Rafnsson V,Tulinius H,De Angelis G,Verdecchia A,Haldorsen T,Tveten U,Eliasch H,Hammar N,Linnersjö A

    更新日期:2004-02-01 00:00:00

  • Genetic effect of low doses of radiation in occupationally exposed workers in coal mines and in coal fired plants.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Horvat D,Bauman A,Racić J

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  • Temperature dependent modification of radiosensitivity following hypoxic cytocidal action of chlorpromazine.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Shenoy MA,Singh BB

    更新日期:1985-01-01 00:00:00

  • NOREC, a Monte Carlo code for simulating electron tracks in liquid water.

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    journal_title:Radiation and environmental biophysics

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    authors: Semenenko VA,Turner JE,Borak TB

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  • Temporarily increased TGFβ following radon spa correlates with reduced pain while serum IL-18 is a general predictive marker for pain sensitivity.

    abstract::Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...

    journal_title:Radiation and environmental biophysics

    pub_type: 临床试验,杂志文章


    authors: Kullmann M,Rühle PF,Harrer A,Donaubauer A,Becker I,Sieber R,Klein G,Fournier C,Fietkau R,Gaipl US,Frey B

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    journal_title:Radiation and environmental biophysics

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    authors: Fesenko S,Fesenko E,Titov I,Karpenko E,Sanzharova N,Fonseca AG,Brown J

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    journal_title:Radiation and environmental biophysics

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    authors: Rao KR,Blattmann H,Cordt I,Fritz-Niggli H

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Girst S,Greubel C,Reindl J,Siebenwirth C,Zlobinskaya O,Dollinger G,Schmid TE

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    journal_title:Radiation and environmental biophysics

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    authors: Walsh L

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    pub_type: 杂志文章


    authors: Mothersill C,Cusack A,Seymour CB

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  • The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats.

    abstract::The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an...

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    pub_type: 杂志文章


    authors: Trnovec T,Volenec K,Bezek S,Kállay Z,Durisová M,Scasnár V,Kubu M,Svoboda V

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Kumlin T,Heikkinen P,Kosma VM,Alhonen L,Jänne J,Juutilainen J

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  • Ionizing radiation-induced structural modification of human red blood cells.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Gwoździński K

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Gantchev T,Keskinova E,Kaltchev M,Angelov D

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    journal_title:Radiation and environmental biophysics

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    journal_title:Radiation and environmental biophysics

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Blattmann H

    更新日期:1992-01-01 00:00:00

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Walsh L,Schneider U

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Miller MW,Dooley DA,Cox C,Carstensen EL

    更新日期:1983-01-01 00:00:00

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Akhlaghi P,Ebrahimi-Khankook A,Vejdani-Noghreiyan A

    更新日期:2017-05-01 00:00:00

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Hissung A,Dertinger H,Heinrich G

    更新日期:1975-06-13 00:00:00

  • A comparative kinetic study on the conversion of fluoresceindiacetate to fluorescein in living cells and in vitro.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Sontag W

    更新日期:1977-04-27 00:00:00

  • Studies on incorporated short-lived beta-emitters with regard to the induction of late effects.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Müller WA,Scháffer EH,Linzner U

    更新日期:1980-01-01 00:00:00

  • Effects of sparsely and densely ionizing radiation on plants.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: De Micco V,Arena C,Pignalosa D,Durante M

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Vaupel PW,Otte J,Manz R

    更新日期:1982-01-01 00:00:00