Interaction of smoking and radon in rats: a biologically based mechanistic model.

Abstract:

:Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acting on transformation and inducing a reduction of the radon dose to the target cells after a smoking period gives an acceptable description of the data.

journal_name

Radiat Environ Biophys

authors

Heidenreich WF,Morlier JP,Monchaux G

doi

10.1007/s00411-005-0006-3

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

145-8

issue

2

eissn

0301-634X

issn

1432-2099

journal_volume

44

pub_type

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