Abstract:
:The naturally synchronous development of early mouse embryos was exploited to address the question, whether micronuclei require a mitosis for expression or whether they can be expressed in the same cell cycle, in which exposure to X-rays or caffeine took place. Experiments with 2-cell and with 4-cell embryos showed that micronuclei are expressed only if a mitosis is completed. There was no indication, even after doses up to 20 Gy, that micronuclei can be expressed before the mitosis was reached, which followed exposure. Furthermore, no nuclear fragmentation pointing to apoptosis could be detected in the cycle, in which cells were exposed. The same results were obtained when caffeine (5 mM) was used as micronucleus inducing agent.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Müller WU,Schlusen I,Streffer Cdoi
10.1007/BF01219345subject
Has Abstractpub_date
1991-01-01 00:00:00pages
117-22issue
2eissn
0301-634Xissn
1432-2099journal_volume
30pub_type
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journal_title:Radiation and environmental biophysics
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更新日期:1991-01-01 00:00:00
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