Fixation, retention and exhalation of carrier-free 11C-labeled carbon monoxide by man.


:Carrier-free 11C-labeled carbon monoxide was produced by proton irradiation of a nitrogen gas flow target via the 14N(p, alpha)11C process followed by on-line reduction of the predominantly formed 11C-carbon dioxide with a yield of 0.4 mCi/muAmin. After appropriate quality control about 2 mCi of carrier-free 11C-carbon monoxide in 500 ml on nitrogen gas were inhaled by test subjects in one breath. The 11C-activity distribution was then followed in vivo by scanning above thorax, head, liver, thigh and os sacrum; simultaneously the 11c-activity of the blood was also followed by batch measurement. The data indicate that part of the 11C-activity migrates from the blood into the intercellular space, while another part is exhaled. The 11C-activity leaves the individual organs with a biological half-life ranging from about 120 to 200 min, a time which is short as compared to the one observed for 51Cr-labeled erythrocytes. A radio gas chromatographic analysis of the exhaled air showed that the 11C-activity leaves the body exculsively in the form of 11C-labeled carbon monoxide. Consequently, metabolism of the 11CO into 11CO2 or other compounds can be excluded.


Radiat Environ Biophys


Weinreich R,Ritzl F,Feinendegen LE,Schnippering HG,Stöcklin G





Has Abstract


1975-12-04 00:00:00












  • Trends in infant leukaemia in West Germany in relation to in utero exposure due to Chernobyl accident.

    abstract::A temporary increase in the incidence of infant leukaemia in Greece was reported by Petridou et al., which was attributed to in utero exposure to ionising radiation resulting from the Chernobyl accident. We performed a similar analysis based on the data of the German Childhood Cancer Registry in order to check whether...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Steiner M,Burkart W,Grosche B,Kaletsch U,Michaelis J

    更新日期:1998-07-01 00:00:00

  • ROS release and Hsp70 expression after exposure to 1,800 MHz radiofrequency electromagnetic fields in primary human monocytes and lymphocytes.

    abstract::The aim of this study is to investigate if 1,800 MHz radiofrequency electromagnetic fields (RF-EMF) can induce reactive oxygen species (ROS) release and/or changes in heat shock protein 70 (Hsp70) expression in human blood cells, using different exposure and co-exposure conditions. Human umbilical cord blood-derived m...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Lantow M,Lupke M,Frahm J,Mattsson MO,Kuster N,Simko M

    更新日期:2006-05-01 00:00:00

  • Measurements on the depth of penetration of light (0.35--1.0 microgram) in tissue.

    abstract::Preliminary results on the spectral dependence of the absorption of light in tissue are presented and discussed with respect to medical laser application. ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Eichler J,Knof J,Lenz H

    更新日期:1977-10-12 00:00:00

  • Mathematical simulation of dose-effect relationships for fish eggs exposed chronically to ionizing radiation.

    abstract::A mathematical model which simulates the observed dose-effect relationships for fish eggs exposed to chronic irradiation is presented. The model assumes that the exposed fish eggs may exist in one of the following states: normally developing, reversibly damaged, and lethally damaged. Reversible damages may be recovere...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Kryshev AI,Sazykina TG,Badalian KD

    更新日期:2006-09-01 00:00:00

  • Confocal microscopy for modeling electron microbeam irradiation of skin.

    abstract::For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the sample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differentiated tiss...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Miller JH,Chrisler WB,Wang X,Sowa MB

    更新日期:2011-08-01 00:00:00

  • Neutron scattering and energy deposition spectra.

    abstract::The influence of neutron scattering in the wall of a spherical proportional counter on the energy deposition spectra and the absorbed dose is investigated. Event probabilities, and frequency and dose-averaged deposited energies are calculated with and without scattering contribution and compared. The change of absorbe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Coppola M,Booz J

    更新日期:1975-06-18 00:00:00

  • Induction of micronuclei in plant cells after exposure to accelerated ion irradiation.

    abstract::The root apex cells of Pisum sativum were irradiated in an U-240 isochronous cyclotron at the Institute for Nuclear Research of the Ukrainian National Academy of Sciences, Kyiv. Several types of micronuclei, differing in structural peculiarities, were observed in the 84 h following exposure to beams of accelerated 1H,...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Vasilenko A,Sidorenko PG

    更新日期:1995-06-01 00:00:00

  • Extracellular calcium and microwave enhancement of membrane conductance in snail neurons.

    abstract::Microwave irradiation has been shown to decrease the input resistance of snail neurons. In this study, we examined the role of extracellular calcium in triggering the microwave-induced enhancement of membrane conductance. Two sets of experiments were conducted. In the first set, nerve cells were superfused using Ringe...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Arber SL,Lin JC

    更新日期:1985-01-01 00:00:00

  • Radiation risks in perspective: radiation-induced cancer among cancer risks.

    abstract::The majority of the public in industrial countries believes that pollution and low doses of radiation are threats to good health. As a matter of fact, when these putative risks are compared to those originating from lifestyle, they appear very small. In particular, the risks associated with low doses of irradiation, e...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Tubiana M

    更新日期:2000-03-01 00:00:00

  • Roles of Saccharomyces cerevisiae RAD17 and CHK1 checkpoint genes in the repair of double-strand breaks in cycling cells.

    abstract::Checkpoints are components of signalling pathways involved in genome stability. We analysed the putative dual functions of Rad17 and Chk1 as checkpoints and in DNA repair using mutant strains of Saccharomyces cerevisiae. Logarithmic populations of the diploid checkpoint-deficient mutants, chk1Delta/chk1Delta and rad17...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Bracesco N,Candreva EC,Keszenman D,Sánchez AG,Soria S,Dell M,Siede W,Nunes E

    更新日期:2007-11-01 00:00:00

  • 5-Fluorouracil treatment after irradiation impairs recovery of bone marrow functions.

    abstract::In mice, persisting radiation-induced growth retardation of hematopoietic tissue suggested that at least part of the surviving stem cells are genetically injured. Additional mitotic stress some time after the radiation insult might remove injured stem cells, thus improving the overall recovery of the irradiated bone m...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: von Wangenheim KH,Peterson HP,Cronkite EP,Feinendegen LE

    更新日期:1987-01-01 00:00:00

  • Mortality from solid cancers other than lung, liver, and bone in relation to external dose among plutonium and non-plutonium workers in the Mayak Worker Cohort.

    abstract::Exposure to ionizing radiation has well-documented long-term effects on cancer rates and other health outcomes in humans. While in vitro experimental studies had demonstrated that the nature of some radiation effects depend on both total dose of the radiation and the dose rate (i.e., the pattern of dose distribution o...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Sokolnikov M,Preston D,Stram DO

    更新日期:2017-03-01 00:00:00

  • Laser flash photolysis study on antioxidant properties of hydroxycinnamic acid derivatives.

    abstract::The antioxidant properties of hydroxycinnamic acid derivatives (HCA) were studied by laser flash photolysis. The transient species with maximum absorption at 360 nm were assigned to the phenoxyl radical of HCA. The SO (4) (.-) induced oxidation of HCA was also investigated. It was shown that the interaction of SO (4) ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Zhu H,Zhao H,Zhang Z,Wang W,Yao S

    更新日期:2006-05-01 00:00:00

  • TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints.

    abstract::The TEL1 gene from Saccharomyces cerevisiae has been shown to be the closest sequence homologue to ATM, the gene mutated in ataxia-telangiectasia (A-T) patients. Functional homology shared between the ATM and Tell proteins has recently been demonstrated based on heterologous expression of the TEL1 gene in human cells ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Cao JP,Meyn MS,Eckardt-Schupp F,Fritz E

    更新日期:2001-12-01 00:00:00

  • Influence of stable iodine on the transfer of 131I into cows' milk.

    abstract::The effect of supplying three different stable iodine levels (about 70, 80, and 160 mg day-1) in the daily feed of four dairy cows has been studied for the excretion pattern of 131I. None of the different treatments had a statistically significant effect. A mean milk transfer coefficient of 0.015 +/- 0.001 d l-1 was d...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Voigt G,Schotola C,Probstmeier G,Röhrmoser G

    更新日期:1994-01-01 00:00:00

  • Spatial variability of the vertical migration of fallout 137Cs in the soil of a pasture, and consequences for long-term predictions.

    abstract::Various transport models are presently used to predict the long-term migration behaviour of fallout radiocesium on the soil. To examine to what extent the uncertainty of these predictions is influenced by the spatial variability of the migration rates, we determined the depth profiles of Chernobyl-derived 137Cs at 100...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Bunzl K,Schimmack W,Zelles L,Albers BP

    更新日期:2000-09-01 00:00:00

  • Temperature dependent modification of radiosensitivity following hypoxic cytocidal action of chlorpromazine.

    abstract::The hypoxic cytotoxic effect of chlorpromazine towards E. coli B/r was observed to be dependent on temperature of incubation and irradiation. Increasing the temperature of incubation from ambient to 37 degrees C followed by irradiation revealed that the organisms showed radiosensitivity of a magnitude which was two to...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Shenoy MA,Singh BB

    更新日期:1985-01-01 00:00:00

  • DS02 fluence spectra for neutrons and gamma rays at Hiroshima and Nagasaki with fluence-to-kerma coefficients and transmission factors for sample measurements.

    abstract::Fluence spectra at several ground distances in Hiroshima and Nagasaki are provided along with associated fluence-to-kerma coefficients from the Dosimetry System 2002 (DS02). Also included are transmission factors for calculating expected responses of in situ sample measurements of neutron activation products such as (...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Egbert SD,Kerr GD,Cullings HM

    更新日期:2007-11-01 00:00:00

  • Protective effects of L-selenomethionine on space radiation induced changes in gene expression.

    abstract::Ionizing radiation can produce adverse biological effects in astronauts during space travel. Of particular concern are the types of radiation from highly energetic, heavy, charged particles known as HZE particles. The aims of our studies are to characterize HZE particle radiation induced biological effects and evaluat...

    journal_title:Radiation and environmental biophysics

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    authors: Stewart J,Ko YH,Kennedy AR

    更新日期:2007-06-01 00:00:00

  • Effects of radioprotectors on the cAMP and cGMP systems.

    abstract::The sulphur-containing radioprotectors mercaptoethylamine (MEA), aminoethylisothiourea (AET), 2- aminothiazoline , 4-oxo-2- aminothiazoline , and S-S-3- oxapentane -1,5- diisothiourea , and the radioprotective biogenic amines serotonin, histamine, and dopamine, caused the elevation of cAMP content and intensified the ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Sobolev AS,Chirkov YuYu,Tertov VV,Kazarov AR

    更新日期:1984-01-01 00:00:00

  • Absorption, retention and tissue distribution of radiocaesium in reindeer: effects of diet and radiocaesium source.

    abstract::Radiocaesium absorption and retention in reindeer (Rangifer tarandus) calves was compared in groups fed diets containing different proportions of lichen and concentrates, and different chemical forms of radiocaesium ((134)CsCl in solution or fallout from the Chernobyl accident). Daily intakes of fallout radiocaesium w...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Skuterud L,Pedersen Ø,Staaland H,Røed KH,Salbu B,Liken A,Hove K

    更新日期:2004-12-01 00:00:00

  • Condensed-history Monte Carlo simulation of the dosimetric distribution of electron microbeam.

    abstract::To evaluate the dose distributions of an electron microbeam and to help optimization of its design, the condensed-history (CH) Monte Carlo simulation algorithm implemented in the Geant4 toolkit was selected as an alternative to the conventionally used analog algorithm. Compared to the analog algorithm, the CH algorith...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Ma Y,Zhou H,Zhuo Y

    更新日期:2006-03-01 00:00:00

  • Triplet state population study in relation to the aggregation of proflavine in frozen solutions.

    abstract::The evolution of the proflavine triplet state population with the extent of aggregation is examines, by ESRmeasurements, as a function of organic solvents and mineral salts, well known for their ability to influence the aggregation process. The intensity of the triplet state population has also been investigated as a ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Lion Y,Saucin M,Van de Vorst A

    更新日期:1975-12-04 00:00:00

  • Radiation-induced carcinogenesis: individual sensitivity and genomic instability.

    abstract::In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for th...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Sabatier L,Lebeau J,Dutrillaux B

    更新日期:1995-11-01 00:00:00

  • Survival of diploid yeast cells to bleomycin in combination with UV-light or hyperthermia.

    abstract::In the present work we have investigated the possible interaction between Bleomycin (B) and UV light or hyperthermia (HT) in the induction of lethal events in diploid yeast populations in the stationary phase of growth. UV and B acting as single agents determine sigmoid survival curves. The combination of UV + B produ...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Barrios E,Candreva EC,Nunes E

    更新日期:1991-01-01 00:00:00

  • Monte Carlo derived absorbed fractions for a voxelized model of Oncorhynchus mykiss, a rainbow trout.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Ruedig E,Caffrey E,Hess C,Higley K

    更新日期:2014-08-01 00:00:00

  • Rate constants studies of the dye-sensitized photoinactivation of lysozyme.

    abstract::The rate constants for the photodynamic inactivation of hen egg-white lysozyme at different temperatures were studied. Arrhenius plots of the methylene blue sensitized photo-inactivation of lysozyme gave an experimental activation energy of 7.5 kcal/mol. The rate constants for the photodynamic inactivation of lysozyme...

    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Silva E

    更新日期:1979-02-23 00:00:00

  • Radiobiological effects of total body irradiation on the spinal cord.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Nevelsky A,Bar-Deroma R,Kuten A

    更新日期:2009-11-01 00:00:00

  • Cause-of-death registers in radiation-contaminated areas of the Russian Federation and Kazakhstan.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章,评审


    authors: Winkelmann RA,Tretyakov FD,Startsev NV,Kolyado IB,Gusev BI,Grosche B,Storm HH,Hall P

    更新日期:2002-03-01 00:00:00

  • Radiobiological data for clinical dosimetry in pion tumour therapy.

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    journal_title:Radiation and environmental biophysics

    pub_type: 杂志文章


    authors: Heyder IR,Pohlit W

    更新日期:1979-08-10 00:00:00