Confusion and dysphoria with low-dose topiramate in a patient with bipolar disorder.

Abstract:

BACKGROUND:Topiramate, a newer antiepileptic agent, may benefit several neurological and psychiatric states, including bipolar disorder. CASE REPORT:A physically healthy, stockily built, 47-year-old, hypomanic Asian male with a >20-year history of uneventful use of psychotropic agents received topiramate in a dose that was stepped up to 100 mg/day across 10 days. He developed dysphoria, confusion, word-finding difficulties, and difficulties in maintaining a train of thought; the symptoms vanished within a week of drug discontinuation, and reappeared 1-2 days after rechallenge at a dose of 25 mg/day. CONCLUSION:It appears that, while confusion is usually a dose-dependent adverse effect of topiramate, certain patients may idiosyncratically develop this adverse effect at very low doses.

journal_name

Bipolar Disord

journal_title

Bipolar disorders

authors

Andrade C

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

211-2

issue

4

eissn

1398-5647

issn

1399-5618

pii

bdi030406

journal_volume

3

pub_type

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