Abstract:
OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates are presented. METHODS:This article begins with a brief review of the concepts involved in mapping genes for BP. The concept of populations that show some degree of historical isolation and their special utility for certain types of gene mapping is presented. Methods of statistical analysis particularly relevant for gene mapping of complex diseases like BP are presented. Finally, several BP gene studies conducted to date in several population isolates are reviewed. RESULTS:Genetic mapping studies of BP have occurred thus far in several isolates or sub-isolates, including the Amish population, Costa Ricans, Finnish, and Canadians (in Quebec), and significant linkage scores have been identified in the latter three isolates. CONCLUSIONS:Possible greater homogeneity and greater consistency of diagnosis are factors that have been cited in several studies of BP done in isolates to date. Another special advantage of working in certain types of population isolate is their appropriateness for using certain types of association or linkage disequilibrium-based approaches at both the genome screening and fine mapping stages. These tests include mapping by linkage disequilibrium analyses, an approach that allows mapping to occur at the population, rather than the pedigree, level.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
Escamilla MAdoi
10.1034/j.1399-5618.2001.30605.xkeywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
299-317issue
6eissn
1398-5647issn
1399-5618pii
030605journal_volume
3pub_type
杂志文章,评审abstract:OBJECTIVE:Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research has implicated a number of key brain regions and neuronal components in the behavioural and cognitive manifestations of bipolar disorder. Do...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2009.00760.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:Outcomes research in bipolar disorders, because of complex clinical variation over-time, offers demanding research design and statistical challenges. Longitudinal studies involving relatively large samples, with outcome measures obtained repeatedly over-time, are required. In this report, statistical methods...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2003.00033.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. METHODS:Children and adolescents offsprin...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12770
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00281.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:Bipolar disorders are associated with high rates of suicide attempts (SAs) and completions. Several factors have been reported to be associated with suicide in persons with bipolar disorder, but most studies to date have been retrospective and have not utilized multivariate statistics to account for the redu...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2006.00369.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:Randomized trials of adjunctive psychotherapy for bipolar disorder are reviewed, in tandem with discussion of cost-effectiveness, mediating mechanisms, and moderators of effects. METHODS:Systematic searches of the MEDLINE and PSYCHLIT databases yielded 19 randomized controlled trials of individual family an...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2009.00715.x
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression. METHODS:Quality of life was assessed using the SF-36 in bipolar patients (n = 958) who had recently experience...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2004.00134.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:Manic patients exhibit impaired verbal learning and memory, particularly following longstanding illness. However, it is unclear whether recognition and recall performance are differentially influenced by a manic mood state. METHODS:To examine this issue, we administered the California Verbal Learning Test a...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2003.00055.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in i...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12625
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:Suicide is a leading cause of death in the USA. Although factors elevating long-term risk for suicide are known and include bipolar disorder, signs of imminent suicide risk are difficult to study and not well specified. Acute risk determinations must be made to determine the appropriate level of care to safe...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12092
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:Laboratory monitoring of patients using lithium is important to prevent harm and to increase effectiveness. The aim of this study is to determine compliance with the guidelines for laboratory monitoring of patients treated with lithium overall and within subgroups. METHODS:Patients having at least one lithi...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12730
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE: To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study. METHODS: Children ages 6-12 were recruited at first visit to clinics associated with four universities. A BPSD diagnosis required t...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2011.00948.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disord...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00267.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:Cognitive remediation therapy (CRT) may benefit people with bipolar disorder type I and II for whom cognitive impairment is a major contributor to disability. Extensive research has demonstrated CRT to improve cognition and psychosocial functioning in people with different diagnoses, but randomised trials of...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12968
更新日期:2020-06-24 00:00:00
abstract:OBJECTIVES:Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions hav...
journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
doi:10.1111/bdi.12784
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00173.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01226.x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Patients with mood disorders may benefit from psychosocial interventions through changes in brain networks underlying emotion processing. In this study, we used functional magnetic resonance imaging (fMRI) to investigate treatment-related changes in emotion processing networks in youth at familial high risk ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.13045
更新日期:2021-01-12 00:00:00
abstract:OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2004.00115.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Bipolar illness is frequently misdiagnosed. Several studies have focused on the underdiagnosis of this condition and the frequent long delay in its recognition. However, the illness is difficult to diagnose and many of its symptoms are shared by other conditions. In order to determine the accuracy of the dia...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00465.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Despite known metabolic effects of second-generation antipsychotics (SGAs) on children and adolescents, comparative effects in youth with different diagnoses remain underreported. We compared differences in metabolic changes three months after starting treatment with SGAs in youth with bipolar disorder and w...
journal_title:Bipolar disorders
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5618.2010.00797.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To examine the nature of executive deficits in euthymic patients with bipolar disorder (BD). METHODS:Fifteen euthymic BD patients and 13 controls were administered a battery of executive tasks including verbal fluency, Stroop, Theory of Mind (ToM) tests and selected subtests from the Cambridge Neuropsycholo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00254.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:The study was designed to test an audit-based quality improvement programme (QIP) addressing lithium prescribing and monitoring in UK mental health services. METHODS:A baseline clinical audit was conducted against the following standards: (i) measurement of renal and thyroid function before initiating treat...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12128
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. METHODS:This paper pro...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12821
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:Neuropsychological studies in subjects with bipolar disorder (BD) have reported deficits on a variety of cognitive measures. However, because the majority of subjects were medicated at the time of testing in previous studies, it is currently unclear whether the pattern of deficits reported is related to BD i...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2009.00669.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS:A total of 62 patients with bipolar I (n = 47) or II (n = ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2010.00807.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12164
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To investigate the use of transcranial direct current stimulation (tDCS) for enhancing working memory and sustained attention in euthymic patients with bipolar disorder. METHODS:Fifteen patients with bipolar disorder received anodal left prefrontal tDCS with an extracephalic cathode (prefrontal condition), ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12350
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/bdi.12126
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:The standardized mortality ratio for suicide in people with epilepsy is reported as 5.1 [95% confidence interval (CI): 3.9-6.6], but this is only partially explained by the high rates of psychiatric comorbidity. This issue was revived when, in 2008, the Food and Drug Administration (FDA) issued an alert on a...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/bdi.12091
更新日期:2013-08-01 00:00:00