Declarative memory impairment in pediatric bipolar disorder.

Abstract:

OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disorder. METHODS:Forty-one children and adolescents with bipolar disorder [21 bipolar I disorder (BP-I), 10 bipolar II disorder (BP-II), and 10 bipolar disorder, not otherwise specified (BP-NOS)] and 17 demographically matched healthy participants completed a standardized learning and memory test. RESULTS:BP-I children recalled and recognized significantly fewer words than healthy subjects, whereas children with BP-II and BP-NOS did not differ from controls. However, individuals with BP-NOS made more perseverative errors and intrusions than the other groups. Severity of mood symptomatology was not associated with memory performance in any bipolar subtype. CONCLUSIONS:Findings suggest that declarative memory impairments in juvenile BP-I are similar to those seen in the adult form of the illness. These impairments do not appear to be secondary to clinical state; rather, they may reflect trait-related impairments. Distinct performance patterns in BP-I, BP-II, and BP-NOS suggest that the broadly defined phenotype is significantly heterogeneous, and may not be informative for pathogenetic investigations of bipolar disorder.

journal_name

Bipolar Disord

journal_title

Bipolar disorders

authors

Glahn DC,Bearden CE,Caetano S,Fonseca M,Najt P,Hunter K,Pliszka SR,Olvera RL,Soares JC

doi

10.1111/j.1399-5618.2005.00267.x

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

546-54

issue

6

eissn

1398-5647

issn

1399-5618

pii

BDI267

journal_volume

7

pub_type

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