Theory of mind and neurocognitive functioning in patients with bipolar disorder.

Abstract:

OBJECTIVES:Studies into social cognition in psychiatric disorders have recently been expanded to address the question of whether or not theory of mind (ToM), i.e., the ability to represent ones own and others mental states, is impaired in bipolar affective disorder (BPD). Results have been mixed so far, mainly due to possible confounding effects of neurocognition, as well as clinical factors such as acuity and current mood. Here, we explored ToM and its associations with neurocognitive functioning in BPD. METHODS:A total of 33 patients with bipolar I disorder (of whom 12 were currently depressed, 10 manic, and 11 remitted) and 29 healthy controls were assessed using a test battery that was identical to the one that was used in previous studies in schizophrenia, comprising diverse neurocognitive tasks, including measures of intelligence, executive functioning, and ToM tasks. RESULTS:The bipolar disorder patient group as a whole and all three clinical subgroups were impaired on all measures of ToM relative to controls, but did not differ from each other in most ToM scores. Patients poorer performance on executive tasks did not fully explain ToM differences between patients and controls, suggesting a partially selective ToM deficit in BPD. CONCLUSIONS:Patients with BPD are impaired in ToM, partially independent of other cognitive dysfunctions and current mood.

journal_name

Bipolar Disord

journal_title

Bipolar disorders

authors

Wolf F,Brüne M,Assion HJ

doi

10.1111/j.1399-5618.2010.00854.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

657-66

issue

6

eissn

1398-5647

issn

1399-5618

journal_volume

12

pub_type

杂志文章
  • Glycogen synthase kinase-3β in patients with bipolar I disorder: results from a prospective study.

    abstract:OBJECTIVES:The enzyme glycogen synthase kinase-3β (GSK3β) is involved in the mechanisms of action of lithium and may play a role in relation to affective states in bipolar disorder. The objectives of the present study were to compare the activity of GSK-3β (measured as levels of phosphorylated GSK-3β [p-GSK-3β]) betwee...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bdi.12400

    authors: Jacoby AS,Munkholm K,Vinberg M,Joaquim HG,Talib LL,Gattaz WF,Kessing LV

    更新日期:2016-06-01 00:00:00

  • Monitoring lithium therapy: the impact of a quality improvement programme in the UK.

    abstract:OBJECTIVES:The study was designed to test an audit-based quality improvement programme (QIP) addressing lithium prescribing and monitoring in UK mental health services. METHODS:A baseline clinical audit was conducted against the following standards: (i) measurement of renal and thyroid function before initiating treat...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12128

    authors: Paton C,Adroer R,Barnes TR

    更新日期:2013-12-01 00:00:00

  • Cognitive variability in bipolar II disorder: who is cognitively impaired and who is preserved.

    abstract:OBJECTIVES:Although it is well established that euthymic patients with bipolar disorder can have cognitive impairment, substantial heterogeneity exists and little is known about the extent and severity of impairment within the bipolar II disorder subtype. Therefore, the main aim of this study was to analyze cognitive v...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12385

    authors: Solé B,Jiménez E,Torrent C,Del Mar Bonnin C,Torres I,Reinares M,Priego Á,Salamero M,Colom F,Varo C,Vieta E,Martínez-Arán A

    更新日期:2016-05-01 00:00:00

  • Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants.

    abstract:OBJECTIVE:To examine gender differences in a large sample of patients with bipolar illness. METHODS:Exploratory analysis of baseline data from the first 500 patients in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), a multi-center NIMH project. Participants are allowed to have medical and...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1399-5618.2005.00237.x

    authors: Baldassano CF,Marangell LB,Gyulai L,Ghaemi SN,Joffe H,Kim DR,Sagduyu K,Truman CJ,Wisniewski SR,Sachs GS,Cohen LS

    更新日期:2005-10-01 00:00:00

  • The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology.

    abstract:AIMS:To systematically review the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)-bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognit...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12847

    authors: Gottlieb JF,Benedetti F,Geoffroy PA,Henriksen TEG,Lam RW,Murray G,Phelps J,Sit D,Swartz HA,Crowe M,Etain B,Frank E,Goel N,Haarman BCM,Inder M,Kallestad H,Jae Kim S,Martiny K,Meesters Y,Porter R,Riemersma-van der L

    更新日期:2019-12-01 00:00:00

  • Disability and its treatment in bipolar disorder patients.

    abstract::Bipolar disorders (BPD) are major, life-long psychiatric illnesses found in 2-5% of the population. Prognosis for BPD was once considered relatively favorable, but contemporary findings suggest that disability and poor outcomes are prevalent, despite major therapeutic advances. Syndromal recovery from acute episodes o...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-5618.2007.00430.x

    authors: Huxley N,Baldessarini RJ

    更新日期:2007-02-01 00:00:00

  • Immune activation by casein dietary antigens in bipolar disorder.

    abstract:OBJECTIVES:  Inflammation and other immune processes are increasingly linked to psychiatric diseases. Antigenic triggers specific to bipolar disorder are not yet defined. We tested whether antibodies to bovine milk caseins were associated with bipolar disorder, and whether patients recognized different epitopes of the ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2010.00879.x

    authors: Severance EG,Dupont D,Dickerson FB,Stallings CR,Origoni AE,Krivogorsky B,Yang S,Haasnoot W,Yolken RH

    更新日期:2010-12-01 00:00:00

  • Cigarette smoking is associated with suicidality in bipolar disorder.

    abstract:OBJECTIVES:Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear. METHODS:In this prospective observational study of 116 individuals with bipolar disorder, we examined the association between smoking and suic...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2009.00744.x

    authors: Ostacher MJ,Lebeau RT,Perlis RH,Nierenberg AA,Lund HG,Moshier SJ,Sachs GS,Simon NM

    更新日期:2009-11-01 00:00:00

  • Emotional modulation of response inhibition in stable patients with bipolar I disorder: a comparison with healthy and schizophrenia subjects.

    abstract:OBJECTIVES:Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compare...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2011.00906.x

    authors: Gopin CB,Burdick KE,Derosse P,Goldberg TE,Malhotra AK

    更新日期:2011-03-01 00:00:00

  • Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.

    abstract:OBJECTIVES:Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suici...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12954

    authors: Sankar A,Purves K,Colic L,Cox Lippard ET,Millard H,Fan S,Spencer L,Wang F,Pittman B,Constable RT,Gross JJ,Blumberg HP

    更新日期:2020-06-10 00:00:00

  • Missed bipolarity and psychiatric comorbidity in women with postpartum depression.

    abstract:OBJECTIVE:To investigate the diagnostic profile of women referred for postpartum depression. METHODS:Fifty-six women seen consecutively with the referral diagnosis of postpartum depression were administered structured instruments to gather information about their DSM-IV Axis I diagnoses. RESULTS:In terms of frequency...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2008.00606.x

    authors: Sharma V,Khan M,Corpse C,Sharma P

    更新日期:2008-09-01 00:00:00

  • Mood spectrum symptoms during a major depressive episode: Differences between 145 patients with bipolar disorder and 155 patients with major depressive disorder. Arguments for a dimensional approach.

    abstract:BACKGROUND:Several studies have challenged the traditional unipolar-bipolar dichotomy in favor of a more dimensional approach. OBJECTIVE:To evaluate the differences in mood spectrum between patients with bipolar disorder (BD) and major depressive disorder (MDD) during a major depressive episode (MDE). METHOD:Study pa...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12855

    authors: Cuomo A,Aguglia A,Aguglia E,Bolognesi S,Goracci A,Maina G,Mineo L,Rucci P,Sillari S,Fagiolini A

    更新日期:2020-06-01 00:00:00

  • Suicide risk in bipolar patients: the role of co-morbid substance use disorders.

    abstract:OBJECTIVE:Bipolar disorder is associated with a high frequency of both completed suicides and suicide attempts. The primary aim of this study was to identify clinical predictors of suicide attempts in subjects with bipolar disorder. METHODS:We studied 336 subjects with a diagnosis of bipolar I, bipolar II, or schizoaf...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1034/j.1399-5618.2003.00017.x

    authors: Dalton EJ,Cate-Carter TD,Mundo E,Parikh SV,Kennedy JL

    更新日期:2003-02-01 00:00:00

  • Influence of mood state on capacity to consent to research in patients with bipolar disorder.

    abstract:OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00525.x

    authors: Misra S,Socherman R,Park BS,Hauser P,Ganzini L

    更新日期:2008-03-01 00:00:00

  • Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence.

    abstract:OBJECTIVES:The notion that sufferers of bipolar disorder achieve complete syndromal and functional recovery between illness episodes has been brought into question by evidence that a large proportion of patients fail to regain premorbid levels of functioning after the resolution of major affective symptoms. A growing b...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1399-5618.2006.00277.x

    authors: Robinson LJ,Ferrier IN

    更新日期:2006-04-01 00:00:00

  • Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

    abstract:OBJECTIVES:To compare the clinical features and course of major depressive episodes (MDEs) occurring in subjects with bipolar I disorder (BD-I), bipolar II disorder (BD-II), and major depressive disorder (MDD). METHODS:Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (2001-2002)...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2012.01009.x

    authors: Moreno C,Hasin DS,Arango C,Oquendo MA,Vieta E,Liu S,Grant BF,Blanco C

    更新日期:2012-05-01 00:00:00

  • Cognitive behavioral rehabilitation for bipolar disorder patients: A randomized controlled trial.

    abstract:OBJECTIVES:Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions hav...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bdi.12784

    authors: Gomes BC,Rocca CC,Belizario GO,de B F Fernandes F,Valois I,Olmo GC,Fachin RVP,Farhat LC,Lafer B

    更新日期:2019-11-01 00:00:00

  • Confusion and dysphoria with low-dose topiramate in a patient with bipolar disorder.

    abstract:BACKGROUND:Topiramate, a newer antiepileptic agent, may benefit several neurological and psychiatric states, including bipolar disorder. CASE REPORT:A physically healthy, stockily built, 47-year-old, hypomanic Asian male with a >20-year history of uneventful use of psychotropic agents received topiramate in a dose tha...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:

    authors: Andrade C

    更新日期:2001-08-01 00:00:00

  • Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons.

    abstract:OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2004.00164.x

    authors: Di Daniel E,Mudge AW,Maycox PR

    更新日期:2005-02-01 00:00:00

  • Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode.

    abstract:OBJECTIVES:To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. METHODS:Children and adolescents offsprin...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12770

    authors: Nery FG,Weber WA,Blom TJ,Welge J,Patino LR,Strawn JR,Chu WJ,Adler CM,Komoroski RA,Strakowski SM,DelBello MP

    更新日期:2019-06-01 00:00:00

  • No evidence for physical anhedonia as a candidate symptom or an endophenotype in bipolar affective disorder.

    abstract:OBJECTIVES:Bipolar affective disorder (BPAD) is clinically and genetically heterogeneous and the affected phenotype is poorly defined, hampering studies of its genetic basis. Studies of specific, familial, clinical indicators of BPAD may be useful for identifying heritable forms. Homogeneous forms of the disease may be...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00413.x

    authors: Etain B,Roy I,Henry C,Rousseva A,Schürhoff F,Leboyer M,Bellivier F

    更新日期:2007-11-01 00:00:00

  • Does lithium protect against dementia?

    abstract:OBJECTIVE:To investigate whether treatment with lithium in patients with mania or bipolar disorder is associated with a decreased rate of subsequent dementia. METHODS:Linkage of register data on prescribed lithium in all patients discharged from psychiatric health care service with a diagnosis of mania or bipolar diso...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2009.00788.x

    authors: Kessing LV,Forman JL,Andersen PK

    更新日期:2010-02-01 00:00:00

  • Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II.

    abstract:OBJECTIVES:Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed the reproducibility of thinner frontotemporal cortices in BD type II, compared longitudinal changes...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12771

    authors: Zak N,Bøen E,Boye B,Andreassen OA,Doan NT,Malt UF,Westlye LT,Elvsåshagen T

    更新日期:2019-09-01 00:00:00

  • Family history of psychosis moderates early auditory cortical response abnormalities in non-psychotic bipolar disorder.

    abstract:OBJECTIVES:Bipolar I disorder is a disabling illness affecting 1% of people worldwide. Family and twin studies suggest that psychotic bipolar disorder (BDP) represents a homogeneous subgroup with an etiology distinct from non-psychotic bipolar disorder (BDNP) and partially shared with schizophrenia. Studies of auditory...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12110

    authors: Hamm JP,Ethridge LE,Shapiro JR,Pearlson GD,Tamminga CA,Sweeney JA,Keshavan MS,Thaker GK,Clementz BA

    更新日期:2013-11-01 00:00:00

  • The effectiveness of restarted lithium treatment after discontinuation: reviewing the evidence for discontinuation-induced refractoriness.

    abstract:OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/bdi.12105

    authors: de Vries C,van Bergen A,Regeer EJ,Benthem E,Kupka RW,Boks MP

    更新日期:2013-09-01 00:00:00

  • Association of thalamic serotonin transporter and interleukin-10 in bipolar I disorder: a SPECT study.

    abstract:OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12164

    authors: Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

    更新日期:2014-05-01 00:00:00

  • The longitudinal course of bipolar disorder as revealed through weekly text messaging: a feasibility study.

    abstract:OBJECTIVES:To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS:A total of 62 patients with bipolar I (n = 47) or II (n = ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2010.00807.x

    authors: Bopp JM,Miklowitz DJ,Goodwin GM,Stevens W,Rendell JM,Geddes JR

    更新日期:2010-05-01 00:00:00

  • Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine.

    abstract:OBJECTIVE:The present study evaluated inhaled loxapine for the acute treatment of agitation in patients with bipolar I disorder. METHODS:A Phase 3, randomized, double blind, placebo-controlled, parallel group inpatient study was performed at 17 psychiatric research facilities. Agitated patients (N=314) with bipolar I ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-5618.2011.00975.x

    authors: Kwentus J,Riesenberg RA,Marandi M,Manning RA,Allen MH,Fishman RS,Spyker DA,Kehne JH,Cassella JV

    更新日期:2012-02-01 00:00:00

  • Differences between unipolar mania and bipolar-I disorder: Evidence from nine epidemiological studies.

    abstract:OBJECTIVES:Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from nine population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and de...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12732

    authors: Angst J,Rössler W,Ajdacic-Gross V,Angst F,Wittchen HU,Lieb R,Beesdo-Baum K,Asselmann E,Merikangas KR,Cui L,Andrade LH,Viana MC,Lamers F,Penninx BW,de Azevedo Cardoso T,Jansen K,Dias de Mattos Souza L,Azevedo da Silva R

    更新日期:2019-08-01 00:00:00

  • Dimensional psychopathology in offspring of parents with bipolar disorder.

    abstract:OBJECTIVES:To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL). METHODS:Offspring of parents with BP, who were healthy or had non-BP disorders (any psychiatric disorder other than BP...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2011.00966.x

    authors: Diler RS,Birmaher B,Axelson D,Obreja M,Monk K,Hickey MB,Goldstein B,Goldstein T,Sakolsky D,Iyengar S,Brent D,Kupfer D

    更新日期:2011-11-01 00:00:00