Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence.

abstract：OBJECTIVES:Patients experiencing an acute mood episode of bipolar disorder are impaired on cognitive tests of executive functioning when compared with healthy subjects. However, it is unclear to what extent executive dysfunction exists (i) during syndromal remission, when mood symptoms are attenuated, and (ii) during t...

journal_title：Bipolar disorders

authors： Fleck DE,Shear PK,Madore M,Strakowski SM

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Neurocognitive deficits are prevalent, persistent, and implicated as mediators of functional impairment in adults with bipolar disorder. Notwithstanding progress in the development of pharmacological treatments for various phases of bipolar disorder, no available treatment has been proven to be reliably effi...

journal_title：Bipolar disorders

authors： McIntyre RS,Soczynska JK,Woldeyohannes HO,Miranda A,Vaccarino A,Macqueen G,Lewis GF,Kennedy SH

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...

journal_title：Bipolar disorders

authors： Fasmer OB,Oedegaard KJ

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:Mental imagery abnormalities occur across psychopathologies and are hypothesized to drive emotional difficulties in bipolar disorder (BD). A comprehensive assessment of mental imagery in BD is lacking. We aimed to test whether (i) mental imagery abnormalities (abnormalities in cognitive stages and subjective...

journal_title：Bipolar disorders

authors： Di Simplicio M,Renner F,Blackwell SE,Mitchell H,Stratford HJ,Watson P,Myers N,Nobre AC,Lau-Zhu A,Holmes EA

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:There is wide recognition that symptom ratings alone are inadequate to measure outcomes in bipolar disorder (BD), and quality of life (QoL) has been proposed as an important separable construct. Although a literature on QoL in BD exists, there is no disorder-specific measure of QoL in BD. In 2004, we embarke...

journal_title：Bipolar disorders

authors： Michalak EE,Murray G,Collaborative RESearch Team to Study Psychosocial Issues in Bipolar Disorder (CREST.BD).

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:Pediatric bipolar disorder is currently diagnosed based on signs and symptoms, and without objective diagnostic biomarkers. In the present study, we investigated the utility of structural neuroanatomical signatures of the amygdala to objectively differentiate individual subjects with pediatric bipolar disord...

journal_title：Bipolar disorders

authors： Mwangi B,Spiker D,Zunta-Soares GB,Soares JC

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psycho...

journal_title：Bipolar disorders

authors： Smith LM,Johns LC,Mitchell R

更新日期：2017-09-01 00:00:00

abstract：:Bipolar disorders (BPD) are major, life-long psychiatric illnesses found in 2-5% of the population. Prognosis for BPD was once considered relatively favorable, but contemporary findings suggest that disability and poor outcomes are prevalent, despite major therapeutic advances. Syndromal recovery from acute episodes o...

journal_title：Bipolar disorders

authors： Huxley N,Baldessarini RJ

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:Neuropsychological studies in subjects with bipolar disorder (BD) have reported deficits on a variety of cognitive measures. However, because the majority of subjects were medicated at the time of testing in previous studies, it is currently unclear whether the pattern of deficits reported is related to BD i...

journal_title：Bipolar disorders

authors： Roiser JP,Cannon DM,Gandhi SK,Taylor Tavares J,Erickson K,Wood S,Klaver JM,Clark L,Zarate CA Jr,Sahakian BJ,Drevets WC

更新日期：2009-03-01 00:00:00

abstract：:Research into postnatal mood disorders to date has concentrated on depressive syndromes of varying severity and full-blown acute puerperal mania. However, clinical experience, backed up by a review of the literature, indicates that milder hypomanic symptoms also occur in the early puerperium. Although these symptoms m...

journal_title：Bipolar disorders

authors： Heron J,Craddock N,Jones I

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association of obesity with BD i...

journal_title：Bipolar disorders

authors： Baskaran A,Cha DS,Powell AM,Jalil D,McIntyre RS

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:In children with pediatric bipolar disorder (PBD), a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression has been identified on the Child Behavior Checklist (CBCL-PBD profile). In Germany, no epidemiological study has included PBD to date. OBJECTIVES:To estimate...

journal_title：Bipolar disorders

authors： Holtmann M,Bölte S,Goth K,Döpfner M,Plück J,Huss M,Fegert JM,Lehmkuhl G,Schmeck K,Poustka F

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:Many morphometric magnetic resonance imaging (MRI) studies that have investigated the presence of gray matter (GM) volume abnormalities associated with the diagnosis of bipolar disorder (BD) have reported conflicting findings. None of these studies has compared patients with recent-onset psychotic BD with as...

journal_title：Bipolar disorders

authors： de Azevedo-Marques Périco C,Duran FL,Zanetti MV,Santos LC,Murray RM,Scazufca M,Menezes PR,Busatto GF,Schaufelberger MS

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:Suicide is a leading cause of death in the USA. Although factors elevating long-term risk for suicide are known and include bipolar disorder, signs of imminent suicide risk are difficult to study and not well specified. Acute risk determinations must be made to determine the appropriate level of care to safe...

journal_title：Bipolar disorders

authors： Chesin M,Stanley B

更新日期：2013-08-01 00:00:00

abstract：:Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increas...

journal_title：Bipolar disorders

authors： McIntyre R,Katzman M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment. METHODS:In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm...

journal_title：Bipolar disorders

authors： Bjoerke-Bertheussen J,Schoeyen H,Andreassen OA,Malt UF,Oedegaard KJ,Morken G,Sundet K,Vaaler AE,Auestad B,Kessler U

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation...

journal_title：Bipolar disorders

authors： Zhang L,Opmeer EM,van der Meer L,Aleman A,Ćurčić-Blake B,Ruhé HG

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Considerable preclinical biochemical and behavioral data suggest that protein kinase C inhibition would bring about antimanic effects. Notably, the structurally highly dissimilar antimanic agents lithium and valproate, when administered in therapeutically relevant paradigms, attenuate protein kinase C [corre...

journal_title：Bipolar disorders

authors： Zarate CA Jr,Singh JB,Carlson PJ,Quiroz J,Jolkovsky L,Luckenbaugh DA,Manji HK

更新日期：2007-09-01 00:00:00

abstract：:It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...

journal_title：Bipolar disorders

authors： Chen G,Masana MI,Manji HK

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:In this report, we seek to (i) identify a potential neuroimaging endophenotype for bipolar disorder (BD) in emotion regulatory and autonomic circuitry in young first-degree relatives of persons with BD; and (ii) replicate our previous work identifying the functional neuroanatomy of working memory (WM) in an ...

journal_title：Bipolar disorders

authors： Thermenos HW,Makris N,Whitfield-Gabrieli S,Brown AB,Giuliano AJ,Lee EH,Faraone SV,Tsuang MT,Seidman LJ

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Bipolar illness is frequently misdiagnosed. Several studies have focused on the underdiagnosis of this condition and the frequent long delay in its recognition. However, the illness is difficult to diagnose and many of its symptoms are shared by other conditions. In order to determine the accuracy of the dia...

journal_title：Bipolar disorders

authors： Stewart C,El-Mallakh RS

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:To compare the concentrations of high-energy phosphorus metabolites associated with mitochondrial function in the frontal lobe of depressed adolescents with bipolar disorder (BD) and healthy controls (HC). METHODS:We used in vivo phosphorus-31 magnetic resonance spectroscopy ((31) P-MRS) at 3 Tesla to measu...

journal_title：Bipolar disorders

authors： Shi XF,Kondo DG,Sung YH,Hellem TL,Fiedler KK,Jeong EK,Huber RS,Renshaw PF

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Caregivers of people with bipolar disorder often have depression and health problems. This study aimed to evaluate the sustained effects of a 12-15 week psychoeducational intervention on the health and mental health of caregivers of persons with bipolar disorder. We also evaluated the effects of the interven...

journal_title：Bipolar disorders

authors： Perlick DA,Jackson C,Grier S,Huntington B,Aronson A,Luo X,Miklowitz DJ

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Data from several studies suggest that medications, such as ketoconazole, which lower cortisol levels, may be effective for major depressive disorder (MDD). As with MDD, the manic, depressive, and mixed phases of bipolar disorder are frequently associated with elevated cortisol levels. The literature on the ...

journal_title：Bipolar disorders

authors： Brown ES,Bobadilla L,Rush AJ

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:To examine the nature of executive deficits in euthymic patients with bipolar disorder (BD). METHODS:Fifteen euthymic BD patients and 13 controls were administered a battery of executive tasks including verbal fluency, Stroop, Theory of Mind (ToM) tests and selected subtests from the Cambridge Neuropsycholo...

journal_title：Bipolar disorders

authors： Olley AL,Malhi GS,Bachelor J,Cahill CM,Mitchell PB,Berk M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The present study evaluated inhaled loxapine for the acute treatment of agitation in patients with bipolar I disorder. METHODS:A Phase 3, randomized, double blind, placebo-controlled, parallel group inpatient study was performed at 17 psychiatric research facilities. Agitated patients (N=314) with bipolar I ...

journal_title：Bipolar disorders

authors： Kwentus J,Riesenberg RA,Marandi M,Manning RA,Allen MH,Fishman RS,Spyker DA,Kehne JH,Cassella JV

更新日期：2012-02-01 00:00:00

abstract：:The widely held clinical view of 'antidepressants' as highly effective and specific for the treatment of all types of depressive disorders is exaggerated. This sobering conclusion is supported by recent findings from the NIMH-sponsored STEP-BD and STAR*D projects. Antidepressants have limited short-term efficacy in un...

journal_title：Bipolar disorders

authors： Ghaemi SN

更新日期：2008-12-01 00:00:00

abstract：:Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...

journal_title：Bipolar disorders

authors： Savitz J,Solms M,Ramesar R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. METHODS:We assessed polarity at onset in patie...

journal_title：Bipolar disorders

authors： Forty L,Jones L,Jones I,Smith DJ,Caesar S,Fraser C,Gordon-Smith K,Hyde S,Craddock N

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic-induced weight gain in b...

journal_title：Bipolar disorders

authors： Bonaccorso S,Sodhi M,Li J,Bobo WV,Chen Y,Tumuklu M,Theleritis C,Jayathilake K,Meltzer HY

更新日期：2015-08-01 00:00:00