Polarity at illness onset in bipolar I disorder and clinical course of illness.

abstract：OBJECTIVES:We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic-induced weight gain in b...

journal_title：Bipolar disorders

authors： Bonaccorso S,Sodhi M,Li J,Bobo WV,Chen Y,Tumuklu M,Theleritis C,Jayathilake K,Meltzer HY

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...

journal_title：Bipolar disorders

authors： Di Daniel E,Mudge AW,Maycox PR

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...

journal_title：Bipolar disorders

authors： McKenna BS,Sutherland AN,Legenkaya AP,Eyler LT

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Several lines of evidence suggest that deficits in cognition persist in bipolar patients during periods of euthymia. Working memory impairment has been observed in euthymic bipolar patients and noted to be a significant source of functional deficits in psychiatric disorders. Functional changes associated wit...

journal_title：Bipolar disorders

authors： Adler CM,Holland SK,Schmithorst V,Tuchfarber MJ,Strakowski SM

更新日期：2004-12-01 00:00:00

abstract：:Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...

journal_title：Bipolar disorders

authors： Chuang DM,Chen RW,Chalecka-Franaszek E,Ren M,Hashimoto R,Senatorov V,Kanai H,Hough C,Hiroi T,Leeds P

更新日期：2002-04-01 00:00:00

abstract：:Research into postnatal mood disorders to date has concentrated on depressive syndromes of varying severity and full-blown acute puerperal mania. However, clinical experience, backed up by a review of the literature, indicates that milder hypomanic symptoms also occur in the early puerperium. Although these symptoms m...

journal_title：Bipolar disorders

authors： Heron J,Craddock N,Jones I

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association of obesity with BD i...

journal_title：Bipolar disorders

authors： Baskaran A,Cha DS,Powell AM,Jalil D,McIntyre RS

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Laboratory monitoring of patients using lithium is important to prevent harm and to increase effectiveness. The aim of this study is to determine compliance with the guidelines for laboratory monitoring of patients treated with lithium overall and within subgroups. METHODS:Patients having at least one lithi...

journal_title：Bipolar disorders

authors： Nederlof M,Egberts TC,van Londen L,de Rotte MC,Souverein PC,Herings RM,Heerdink ER

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS:Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healt...

journal_title：Bipolar disorders

authors： Rodríguez-Cano E,Alonso-Lana S,Sarró S,Fernández-Corcuera P,Goikolea JM,Vieta E,Maristany T,Salvador R,McKenna PJ,Pomarol-Clotet E

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment. METHODS:In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm...

journal_title：Bipolar disorders

authors： Bjoerke-Bertheussen J,Schoeyen H,Andreassen OA,Malt UF,Oedegaard KJ,Morken G,Sundet K,Vaaler AE,Auestad B,Kessler U

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Affective psychoses and bipolar disorders have been neglected in the development of early intervention strategies. This paper aims to gather current knowledge on the early phase of bipolar disorders in order to define new targets for early intervention. METHODS:Literature review based on the main computerize...

journal_title：Bipolar disorders

authors： Conus P,Ward J,Hallam KT,Lucas N,Macneil C,McGorry PD,Berk M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Despite effective pharmacological treatments for bipolar disorder, we still lack a comprehensive pathophysiological model of the illness. Recent neurobiological research has implicated a number of key brain regions and neuronal components in the behavioural and cognitive manifestations of bipolar disorder. Do...

journal_title：Bipolar disorders

authors： Cousins DA,Butts K,Young AH

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:Diagnosis and management of bipolar disorder (BD) are limited by the absence of available biomarkers. Allostatic load (AL) represents the strain that stress, including the effects of acute phases and inter-episode chronic mood instability, exerts on interconnected biological systems. This study aimed to oper...

journal_title：Bipolar disorders

authors： Dargél AA,Volant S,Brietzke E,Etain B,Olié E,Azorin JM,Gard S,Bellivier F,Bougerol T,Kahn JP,Roux P,Aubin V,Courtet P,Leboyer M,Henry C,FACE-BD collaborators.

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...

journal_title：Bipolar disorders

authors： Singh J,Mattoo SK,Sharan P,Basu D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:The notion that sufferers of bipolar disorder achieve complete syndromal and functional recovery between illness episodes has been brought into question by evidence that a large proportion of patients fail to regain premorbid levels of functioning after the resolution of major affective symptoms. A growing b...

journal_title：Bipolar disorders

authors： Robinson LJ,Ferrier IN

更新日期：2006-04-01 00:00:00

abstract：:Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increas...

journal_title：Bipolar disorders

authors： McIntyre R,Katzman M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Outcomes research in bipolar disorders, because of complex clinical variation over-time, offers demanding research design and statistical challenges. Longitudinal studies involving relatively large samples, with outcome measures obtained repeatedly over-time, are required. In this report, statistical methods...

journal_title：Bipolar disorders

authors： Hennen J

更新日期：2003-06-01 00:00:00

abstract：:Bipolar disorders (BPD) are major, life-long psychiatric illnesses found in 2-5% of the population. Prognosis for BPD was once considered relatively favorable, but contemporary findings suggest that disability and poor outcomes are prevalent, despite major therapeutic advances. Syndromal recovery from acute episodes o...

journal_title：Bipolar disorders

authors： Huxley N,Baldessarini RJ

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:Mismatch negativity (MMN) and its magnetic counterpart (MMNm) are thought to reflect an automatic process that detects a difference between an incoming stimulus and the sensory memory trace of preceding stimuli. In patients with schizophrenia, an attenuation of the MMN/MMNm amplitude has been repeatedly repo...

journal_title：Bipolar disorders

authors： Shimano S,Onitsuka T,Oribe N,Maekawa T,Tsuchimoto R,Hirano S,Ueno T,Hirano Y,Miura T,Kanba S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:Caregivers of people with bipolar disorder often have depression and health problems. This study aimed to evaluate the sustained effects of a 12-15 week psychoeducational intervention on the health and mental health of caregivers of persons with bipolar disorder. We also evaluated the effects of the interven...

journal_title：Bipolar disorders

authors： Perlick DA,Jackson C,Grier S,Huntington B,Aronson A,Luo X,Miklowitz DJ

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS:A total of 62 patients with bipolar I (n = 47) or II (n = ...

journal_title：Bipolar disorders

authors： Bopp JM,Miklowitz DJ,Goodwin GM,Stevens W,Rendell JM,Geddes JR

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) is a psychiatric disorder with high morbidity and mortality that cannot be distinguished from major depressive disorder (MDD) until the first manic episode. A biomarker able to differentiate BD and MDD could help clinicians avoid risks of treating BD with antidepressants without mood st...

journal_title：Bipolar disorders

authors： Lan MJ,Chhetry BT,Oquendo MA,Sublette ME,Sullivan G,Mann JJ,Parsey RV

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study. METHODS:Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either...

journal_title：Bipolar disorders

authors： Sharma V,Smith A,Mazmanian D

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:Previous studies have indicated abnormalities in response flexibility in pediatric bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of behavioral and emotional dysregulation that is characteristic of BD, since depressed and manic patients respond inflexibly to emotiona...

journal_title：Bipolar disorders

authors： Nelson EE,Vinton DT,Berghorst L,Towbin KE,Hommer RE,Dickstein DP,Rich BA,Brotman MA,Pine DS,Leibenluft E

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Depression research historically uses both self- and clinician ratings of symptoms with significant and substantial correlations. It is often assumed that manic patients lack insight and cannot accurately report their symptoms. This delayed the development of self-rating scales for mania, but several scales ...

journal_title：Bipolar disorders

authors： Meyer TD,Crist N,La Rosa N,Ye B,Soares JC,Bauer IE

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:To determine the effects of mood and additional clinical variables on different domains of current interviewer-rated social adjustment reflecting the reported behaviour of patients with bipolar disorder (BD). METHOD:Multi-center cross-sectional study employing multiple linear regression to investigate wheth...

journal_title：Bipolar disorders

authors： Morriss R,Scott J,Paykel E,Bentall R,Hayhurst H,Johnson T

更新日期：2007-02-01 00:00:00

abstract：:Inositol metabolism is well characterized in yeast at a molecular level, and yeast is the only eukaryote in which genetic, molecular and functional genomic approaches to identify lithium. valproate and inositol targets may be combined readily. It has been shown that lithium inhibits yeast inositol monophosphatase (enc...

journal_title：Bipolar disorders

authors： Agam G,Shamir A,Shaltiel G,Greenberg ML

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...

journal_title：Bipolar disorders

authors： Chengappa KN,Levine J,Gershon S,Mallinger AG,Hardan A,Vagnucci A,Pollock B,Luther J,Buttenfield J,Verfaille S,Kupfer DJ

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:Cognitive remediation therapy (CRT) may benefit people with bipolar disorder type I and II for whom cognitive impairment is a major contributor to disability. Extensive research has demonstrated CRT to improve cognition and psychosocial functioning in people with different diagnoses, but randomised trials of...

journal_title：Bipolar disorders

authors： Strawbridge R,Tsapekos D,Hodsoll J,Mantingh T,Yalin N,McCrone P,Boadu J,Macritchie K,Cella M,Reeder C,Fish J,Wykes T,Young AH

更新日期：2020-06-24 00:00:00

abstract：OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

journal_title：Bipolar disorders

authors： Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

更新日期：2014-05-01 00:00:00