Abstract:
OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study examined if patients with BD demonstrate differential neural changes in encoding and maintenance WM processes that underlie cognitive impairment. METHODS:Event-related functional magnetic resonance imaging during a delayed match-to-sample WM paradigm was employed in 23 inter-episode medicated patients with BD and 23 demographically similar healthy comparison participants. We examined brain regions during encoding and maintenance task intervals to identify regions that demonstrated differential effects between groups. Medication effects and functional connectivity between prefrontal cortex and basal ganglia/thalamus were examined during the encoding interval due to the importance of these regions and the connection among them for encoding into WM. RESULTS:Patients with BD exhibited deficits in task accuracy and attenuated brain response during the encoding interval in areas of the prefrontal cortex, caudate, thalamus, and posterior visual regions. In contrast, patients with BD exhibited hyperactivation in posterior sensory regions during the maintenance interval. Among the BD group, those with greater medication load exhibited the greatest brain response within the prefrontal cortex. CONCLUSIONS:Reduction in activation during the encoding interval suggests that attentional deficits underlie WM deficits in patients with BD. These deficits appear to be trait-like in so far as they were observed during periods of euthymia in patients with BD. Medication effects remain to be further explored as there was evidence of prefrontal changes dependent on medication load.
journal_name
Bipolar Disordjournal_title
Bipolar disordersauthors
McKenna BS,Sutherland AN,Legenkaya AP,Eyler LTdoi
10.1111/bdi.12126subject
Has Abstractpub_date
2014-05-01 00:00:00pages
289-99issue
3eissn
1398-5647issn
1399-5618journal_volume
16pub_type
杂志文章abstract:OBJECTIVES:Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions hav...
journal_title:Bipolar disorders
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abstract:BACKGROUND:Neurocognitive deficits are prevalent, persistent, and implicated as mediators of functional impairment in adults with bipolar disorder. Notwithstanding progress in the development of pharmacological treatments for various phases of bipolar disorder, no available treatment has been proven to be reliably effi...
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journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2008.00606.x
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00122.x
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pub_type: 杂志文章
doi:10.1111/bdi.12222
更新日期:2014-11-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-10-01 00:00:00
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journal_title:Bipolar disorders
pub_type: 杂志文章,随机对照试验
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更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1399-5618.2007.00525.x
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.4.s1.2.x
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1046/j.1399-5618.2003.00087.x
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2005-10-01 00:00:00
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更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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更新日期:2019-06-01 00:00:00
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更新日期:2013-08-01 00:00:00
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