Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder.

abstract：OBJECTIVES:To evaluate the antimanic efficacy and safety of paliperidone extended-release (ER) tablets in patients with bipolar I disorder. METHODS:This study included a 3-week, double-blind, acute treatment phase (paliperidone ER versus placebo, with quetiapine as control), and a 9-week, double-blind, maintenance pha...

journal_title：Bipolar disorders

authors： Vieta E,Nuamah IF,Lim P,Yuen EC,Palumbo JM,Hough DW,Berwaerts J

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Bipolar I disorder is a disabling illness affecting 1% of people worldwide. Family and twin studies suggest that psychotic bipolar disorder (BDP) represents a homogeneous subgroup with an etiology distinct from non-psychotic bipolar disorder (BDNP) and partially shared with schizophrenia. Studies of auditory...

journal_title：Bipolar disorders

authors： Hamm JP,Ethridge LE,Shapiro JR,Pearlson GD,Tamminga CA,Sweeney JA,Keshavan MS,Thaker GK,Clementz BA

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:Considerable preclinical biochemical and behavioral data suggest that protein kinase C inhibition would bring about antimanic effects. Notably, the structurally highly dissimilar antimanic agents lithium and valproate, when administered in therapeutically relevant paradigms, attenuate protein kinase C [corre...

journal_title：Bipolar disorders

authors： Zarate CA Jr,Singh JB,Carlson PJ,Quiroz J,Jolkovsky L,Luckenbaugh DA,Manji HK

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compare...

journal_title：Bipolar disorders

authors： Gopin CB,Burdick KE,Derosse P,Goldberg TE,Malhotra AK

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder is associated with positive emotion disturbance, though it is less clear which specific positive emotions are affected. METHODS:The present study examined differences among distinct positive emotions in recovered bipolar disorder (BD) patients (n = 55) and nonclinical controls (NC) (n = 32)...

journal_title：Bipolar disorders

authors： Gruber J,Culver JL,Johnson SL,Nam JY,Keller KL,Ketter TA

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) is a psychiatric disorder with high morbidity and mortality that cannot be distinguished from major depressive disorder (MDD) until the first manic episode. A biomarker able to differentiate BD and MDD could help clinicians avoid risks of treating BD with antidepressants without mood st...

journal_title：Bipolar disorders

authors： Lan MJ,Chhetry BT,Oquendo MA,Sublette ME,Sullivan G,Mann JJ,Parsey RV

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume o...

journal_title：Bipolar disorders

authors： Tréhout M,Leroux E,Delcroix N,Dollfus S

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:The present study evaluated inhaled loxapine for the acute treatment of agitation in patients with bipolar I disorder. METHODS:A Phase 3, randomized, double blind, placebo-controlled, parallel group inpatient study was performed at 17 psychiatric research facilities. Agitated patients (N=314) with bipolar I ...

journal_title：Bipolar disorders

authors： Kwentus J,Riesenberg RA,Marandi M,Manning RA,Allen MH,Fishman RS,Spyker DA,Kehne JH,Cassella JV

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Several studies have challenged the traditional unipolar-bipolar dichotomy in favor of a more dimensional approach. OBJECTIVE:To evaluate the differences in mood spectrum between patients with bipolar disorder (BD) and major depressive disorder (MDD) during a major depressive episode (MDE). METHOD:Study pa...

journal_title：Bipolar disorders

authors： Cuomo A,Aguglia A,Aguglia E,Bolognesi S,Goracci A,Maina G,Mineo L,Rucci P,Sillari S,Fagiolini A

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suici...

journal_title：Bipolar disorders

authors： Sankar A,Purves K,Colic L,Cox Lippard ET,Millard H,Fan S,Spencer L,Wang F,Pittman B,Constable RT,Gross JJ,Blumberg HP

更新日期：2020-06-10 00:00:00

abstract：OBJECTIVES:Dopamine transmission abnormalities have been implicated in the etiology of bipolar disorder (BPD). However, there is a paucity of receptor imaging studies in BPD, and little information is available about the dopamine system in BPD. Reuptake of synaptic dopamine by the dopamine transporter (DAT) is the prin...

journal_title：Bipolar disorders

authors： Anand A,Barkay G,Dzemidzic M,Albrecht D,Karne H,Zheng QH,Hutchins GD,Normandin MD,Yoder KK

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:Objective physiological indices independently characterizing affective and schizophreniform psychoses would contribute to our understanding of the nature of their relationships. Magnetoencephalography (MEG)-based metrics of altered structural/functional asymmetry in the superior temporal gyrus have previousl...

journal_title：Bipolar disorders

authors： Reite M,Teale P,Rojas DC,Reite E,Asherin R,Hernandez O

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Hypomania in bipolar disorders is characterized by disinhibited, fearless and reward-seeking behavior. This behavioral pattern suggests that early and automatic responding to socio-emotional cues such as facial expressions might be aberrant in hypomania. The present study tested the predictions that particip...

journal_title：Bipolar disorders

authors： Putman P,Saevarsson S,van Honk J

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation...

journal_title：Bipolar disorders

authors： Zhang L,Opmeer EM,van der Meer L,Aleman A,Ćurčić-Blake B,Ruhé HG

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative th...

journal_title：Bipolar disorders

authors： Malhi GS,Outhred T,Das P,Morris G,Hamilton A,Mannie Z

更新日期：2018-06-01 00:00:00

abstract：:Bipolar disorders (BPD) are major, life-long psychiatric illnesses found in 2-5% of the population. Prognosis for BPD was once considered relatively favorable, but contemporary findings suggest that disability and poor outcomes are prevalent, despite major therapeutic advances. Syndromal recovery from acute episodes o...

journal_title：Bipolar disorders

authors： Huxley N,Baldessarini RJ

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...

journal_title：Bipolar disorders

authors： Singh J,Mattoo SK,Sharan P,Basu D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:An emerging body of evidence supports a role for dysfunctional purinergic neurotransmission in mood disorders. Adenosine agonists have been shown to have properties similar to those of dopamine antagonists; there is a well-characterized interaction between adenosine and dopamine receptors in the ventral stria...

journal_title：Bipolar disorders

authors： Weiser M,Burshtein S,Gershon AA,Marian G,Vlad N,Grecu IG,Tocari E,Tiugan A,Hotineanu M,Davis JM

更新日期：2014-06-01 00:00:00

abstract：:The Diagnostic Guidelines Task Force of the International Society for Bipolar Disorders (ISBD) presents in this document and this special issue a summary of the current nosological status of bipolar illness, a discussion of possible revisions to current DSM-IV and ICD-10 definitions, an examination of the relevant lit...

journal_title：Bipolar disorders

authors： Ghaemi SN,Bauer M,Cassidy F,Malhi GS,Mitchell P,Phelps J,Vieta E,Youngstrom E,ISBD Diagnostic Guidelines Task Force.

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:The pathophysiological mechanisms underlying bipolar disorder and its multi-system nature are unclear. Oxidatively generated damage to nucleosides has been demonstrated in metabolic disorders; however, the extent to which this occurs in bipolar disorder in vivo is unknown. We investigated oxidatively generat...

journal_title：Bipolar disorders

authors： Munkholm K,Poulsen HE,Kessing LV,Vinberg M

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:The standardized mortality ratio for suicide in people with epilepsy is reported as 5.1 [95% confidence interval (CI): 3.9-6.6], but this is only partially explained by the high rates of psychiatric comorbidity. This issue was revived when, in 2008, the Food and Drug Administration (FDA) issued an alert on a...

journal_title：Bipolar disorders

authors： Mula M,Sander JW

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates ar...

journal_title：Bipolar disorders

authors： Escamilla MA

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVES:Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. METHODS:We assessed polarity at onset in patie...

journal_title：Bipolar disorders

authors： Forty L,Jones L,Jones I,Smith DJ,Caesar S,Fraser C,Gordon-Smith K,Hyde S,Craddock N

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:This study compared the relative risk for hospitalization of patients with bipolar and manic disorders receiving atypical and typical antipsychotics. METHODS:This retrospective study was based on administrative claims data extracted from the PharMetrics database during 1999 through 2003. Comparisons were ma...

journal_title：Bipolar disorders

authors： Gianfrancesco F,Rajagopalan K,Goldberg JF,Wang RH

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psycho...

journal_title：Bipolar disorders

authors： Smith LM,Johns LC,Mitchell R

更新日期：2017-09-01 00:00:00

abstract：:The quality of life (QoL) construct is becoming more prominent in bipolar disorder (BD) research and practice. Uptake of the construct parallels an earlier trend in schizophrenia research, and coincides with growing interest in psychosocial components of BD's aetiology, phenomenology, and treatment. We argue that, alt...

journal_title：Bipolar disorders

authors： Murray G,Michalak EE

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Affective psychoses and bipolar disorders have been neglected in the development of early intervention strategies. This paper aims to gather current knowledge on the early phase of bipolar disorders in order to define new targets for early intervention. METHODS:Literature review based on the main computerize...

journal_title：Bipolar disorders

authors： Conus P,Ward J,Hallam KT,Lucas N,Macneil C,McGorry PD,Berk M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipo...

journal_title：Bipolar disorders

authors： Payne JL,MacKinnon DF,Mondimore FM,McInnis MG,Schweizer B,Zamoiski RB,McMahon FJ,Nurnberger JI Jr,Rice JP,Scheftner W,Coryell W,Berrettini WH,Kelsoe JR,Byerley W,Gershon ES,DePaulo JR Jr,Potash JB

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...

journal_title：Bipolar disorders

authors： Sachs G,Chengappa KN,Suppes T,Mullen JA,Brecher M,Devine NA,Sweitzer DE

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Acute mania can be modeled in animals using D-amphetamine (AMPH). Acute AMPH injections are associated with monoamine depletion, loss of neurofilaments and neurite degeneration. However, the precise mechanisms underlying AMPH-induced neurotoxicity are still unclear. Several studies have demonstrated that oxi...

journal_title：Bipolar disorders

authors： Frey BN,Martins MR,Petronilho FC,Dal-Pizzol F,Quevedo J,Kapczinski F

更新日期：2006-06-01 00:00:00