Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees.


OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipolar Disorder Collaborative Study and were asked whether they had ever experienced mood symptoms within four weeks postpartum. Women were also asked whether either of two major depressive episodes described in detail occurred postpartum. We examined the odds of postpartum mood symptoms in female siblings, who had previously been pregnant and had a diagnosis of bipolar I, bipolar II, or schizoaffective (bipolar type) disorders (n = 303), given one or more relatives with postpartum mood symptoms. RESULTS:The odds ratio for familial aggregation of postpartum mood symptoms was 2.31 (p = 0.011) in an Any Mood Symptoms analysis (n = 304) and increased to 2.71 (p = 0.005) when manic symptoms were excluded, though this was not significantly different from the Any Mood Symptoms analysis. We also examined familial aggregation of postpartum major depressive episodes; however, the number of subjects was small. CONCLUSIONS:Limitations of the study include the retrospective interview, the fact that the data were collected for other purposes and the inability to control for such factors as medication use. Taken together with previous studies, these data provide support for the hypothesis that there may be a genetic basis for the trait of postpartum mood symptoms generally and postpartum depressive symptoms in particular in women with bipolar disorder. Genetic linkage and association studies incorporating this trait are warranted.


Bipolar Disord


Bipolar disorders


Payne JL,MacKinnon DF,Mondimore FM,McInnis MG,Schweizer B,Zamoiski RB,McMahon FJ,Nurnberger JI Jr,Rice JP,Scheftner W,Coryell W,Berrettini WH,Kelsoe JR,Byerley W,Gershon ES,DePaulo JR Jr,Potash JB




Has Abstract


2008-02-01 00:00:00














  • Population isolates: their special value for locating genes for bipolar disorder.

    abstract:OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates ar...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审


    authors: Escamilla MA

    更新日期:2001-12-01 00:00:00

  • Disability and its treatment in bipolar disorder patients.

    abstract::Bipolar disorders (BPD) are major, life-long psychiatric illnesses found in 2-5% of the population. Prognosis for BPD was once considered relatively favorable, but contemporary findings suggest that disability and poor outcomes are prevalent, despite major therapeutic advances. Syndromal recovery from acute episodes o...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审


    authors: Huxley N,Baldessarini RJ

    更新日期:2007-02-01 00:00:00

  • Compliance with the guidelines for laboratory monitoring of patients treated with lithium: A retrospective follow-up study among ambulatory patients in the Netherlands.

    abstract:OBJECTIVES:Laboratory monitoring of patients using lithium is important to prevent harm and to increase effectiveness. The aim of this study is to determine compliance with the guidelines for laboratory monitoring of patients treated with lithium overall and within subgroups. METHODS:Patients having at least one lithi...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Nederlof M,Egberts TC,van Londen L,de Rotte MC,Souverein PC,Herings RM,Heerdink ER

    更新日期:2019-08-01 00:00:00

  • Allopurinol for mania: a randomized trial of allopurinol versus placebo as add-on treatment to mood stabilizers and/or antipsychotic agents in manic patients with bipolar disorder.

    abstract:OBJECTIVE:An emerging body of evidence supports a role for dysfunctional purinergic neurotransmission in mood disorders. Adenosine agonists have been shown to have properties similar to those of dopamine antagonists; there is a well-characterized interaction between adenosine and dopamine receptors in the ventral stria...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Weiser M,Burshtein S,Gershon AA,Marian G,Vlad N,Grecu IG,Tocari E,Tiugan A,Hotineanu M,Davis JM

    更新日期:2014-06-01 00:00:00

  • Mood spectrum symptoms during a major depressive episode: Differences between 145 patients with bipolar disorder and 155 patients with major depressive disorder. Arguments for a dimensional approach.

    abstract:BACKGROUND:Several studies have challenged the traditional unipolar-bipolar dichotomy in favor of a more dimensional approach. OBJECTIVE:To evaluate the differences in mood spectrum between patients with bipolar disorder (BD) and major depressive disorder (MDD) during a major depressive episode (MDE). METHOD:Study pa...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Cuomo A,Aguglia A,Aguglia E,Bolognesi S,Goracci A,Maina G,Mineo L,Rucci P,Sillari S,Fagiolini A

    更新日期:2020-06-01 00:00:00

  • Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report.

    abstract:OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Ferrier IN,Chowdhury R,Thompson JM,Watson S,Young AH

    更新日期:2004-08-01 00:00:00

  • Electroencephalographic patterns of lithium poisoning: a study of the effect/concentration relationships in the rat.

    abstract:OBJECTIVES:Lithium overdose may result in encephalopathy and electroencephalographic abnormalities. Three poisoning patterns have been identified based on the ingested dose, previous treatment duration and renal function. Whether the severity of lithium-induced encephalopathy depends on the poisoning pattern has not be...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Hanak AS,Malissin I,Poupon J,Risède P,Chevillard L,Mégarbane B

    更新日期:2017-03-01 00:00:00

  • Quality of life in patients with bipolar I depression: data from 920 patients.

    abstract:OBJECTIVE:To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression. METHODS:Quality of life was assessed using the SF-36 in bipolar patients (n = 958) who had recently experience...

    journal_title:Bipolar disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yatham LN,Lecrubier Y,Fieve RR,Davis KH,Harris SD,Krishnan AA

    更新日期:2004-10-01 00:00:00

  • Statistical methods for longitudinal research on bipolar disorders.

    abstract:OBJECTIVES:Outcomes research in bipolar disorders, because of complex clinical variation over-time, offers demanding research design and statistical challenges. Longitudinal studies involving relatively large samples, with outcome measures obtained repeatedly over-time, are required. In this report, statistical methods...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审


    authors: Hennen J

    更新日期:2003-06-01 00:00:00

  • A population-based morphometric MRI study in patients with first-episode psychotic bipolar disorder: comparison with geographically matched healthy controls and major depressive disorder subjects.

    abstract:OBJECTIVES:Many morphometric magnetic resonance imaging (MRI) studies that have investigated the presence of gray matter (GM) volume abnormalities associated with the diagnosis of bipolar disorder (BD) have reported conflicting findings. None of these studies has compared patients with recent-onset psychotic BD with as...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: de Azevedo-Marques Périco C,Duran FL,Zanetti MV,Santos LC,Murray RM,Scazufca M,Menezes PR,Busatto GF,Schaufelberger MS

    更新日期:2011-02-01 00:00:00

  • Elevated levels of urinary markers of oxidatively generated DNA and RNA damage in bipolar disorder.

    abstract:OBJECTIVES:The pathophysiological mechanisms underlying bipolar disorder and its multi-system nature are unclear. Oxidatively generated damage to nucleosides has been demonstrated in metabolic disorders; however, the extent to which this occurs in bipolar disorder in vivo is unknown. We investigated oxidatively generat...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Munkholm K,Poulsen HE,Kessing LV,Vinberg M

    更新日期:2015-05-01 00:00:00

  • Cigarette smoking is associated with suicidality in bipolar disorder.

    abstract:OBJECTIVES:Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear. METHODS:In this prospective observational study of 116 individuals with bipolar disorder, we examined the association between smoking and suic...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Ostacher MJ,Lebeau RT,Perlis RH,Nierenberg AA,Lund HG,Moshier SJ,Sachs GS,Simon NM

    更新日期:2009-11-01 00:00:00

  • Declarative memory impairment in pediatric bipolar disorder.

    abstract:OBJECTIVES:Impaired verbal declarative memory has been proposed as a trait marker for adult bipolar disorder. However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disord...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Glahn DC,Bearden CE,Caetano S,Fonseca M,Najt P,Hunter K,Pliszka SR,Olvera RL,Soares JC

    更新日期:2005-12-01 00:00:00

  • Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II.

    abstract:OBJECTIVES:Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed the reproducibility of thinner frontotemporal cortices in BD type II, compared longitudinal changes...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Zak N,Bøen E,Boye B,Andreassen OA,Doan NT,Malt UF,Westlye LT,Elvsåshagen T

    更新日期:2019-09-01 00:00:00

  • Association of thalamic serotonin transporter and interleukin-10 in bipolar I disorder: a SPECT study.

    abstract:OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

    更新日期:2014-05-01 00:00:00

  • Metabolic effects of second-generation antipsychotics in bipolar youth: comparison with other psychotic and nonpsychotic diagnoses.

    abstract:OBJECTIVES:Despite known metabolic effects of second-generation antipsychotics (SGAs) on children and adolescents, comparative effects in youth with different diagnoses remain underreported. We compared differences in metabolic changes three months after starting treatment with SGAs in youth with bipolar disorder and w...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究


    authors: Moreno C,Merchán-Naranjo J,Alvarez M,Baeza I,Alda JA,Martínez-Cantarero C,Parellada M,Sánchez B,de la Serna E,Giráldez M,Arango C

    更新日期:2010-03-01 00:00:00

  • Randomized trial comparing caregiver-only family-focused treatment to standard health education on the 6-month outcome of bipolar disorder.

    abstract:OBJECTIVES:Caregivers of people with bipolar disorder often have depression and health problems. This study aimed to evaluate the sustained effects of a 12-15 week psychoeducational intervention on the health and mental health of caregivers of persons with bipolar disorder. We also evaluated the effects of the interven...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,随机对照试验


    authors: Perlick DA,Jackson C,Grier S,Huntington B,Aronson A,Luo X,Miklowitz DJ

    更新日期:2018-11-01 00:00:00

  • Clinical nurse specialist care managers' time commitments in a disease-management program for bipolar disorder.

    abstract:OBJECTIVES:As part of a cost-effectiveness analysis for Department of Veterans Affairs Cooperative Studies Program #430, 'Reducing the Efficacy-Effectiveness Gap in Bipolar Disorder,' we conducted a time and motion study to quantify the time psychiatric clinical nurse specialist (CNS) care managers spent providing care...

    journal_title:Bipolar disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Glick HA,Kinosian B,McBride L,Williford WO,Bauer MS,CSP #430 Study Team.

    更新日期:2004-12-01 00:00:00

  • A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder.

    abstract:BACKGROUND:Neurocognitive deficits are prevalent, persistent, and implicated as mediators of functional impairment in adults with bipolar disorder. Notwithstanding progress in the development of pharmacological treatments for various phases of bipolar disorder, no available treatment has been proven to be reliably effi...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,随机对照试验


    authors: McIntyre RS,Soczynska JK,Woldeyohannes HO,Miranda A,Vaccarino A,Macqueen G,Lewis GF,Kennedy SH

    更新日期:2012-11-01 00:00:00

  • A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings.

    abstract:OBJECTIVES:In this report, we seek to (i) identify a potential neuroimaging endophenotype for bipolar disorder (BD) in emotion regulatory and autonomic circuitry in young first-degree relatives of persons with BD; and (ii) replicate our previous work identifying the functional neuroanatomy of working memory (WM) in an ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Thermenos HW,Makris N,Whitfield-Gabrieli S,Brown AB,Giuliano AJ,Lee EH,Faraone SV,Tsuang MT,Seidman LJ

    更新日期:2011-05-01 00:00:00

  • Cognitive behavioral rehabilitation for bipolar disorder patients: A randomized controlled trial.

    abstract:OBJECTIVES:Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions hav...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,随机对照试验


    authors: Gomes BC,Rocca CC,Belizario GO,de B F Fernandes F,Valois I,Olmo GC,Fachin RVP,Farhat LC,Lafer B

    更新日期:2019-11-01 00:00:00

  • Quetiapine for the treatment of bipolar mania in older adults.

    abstract:OBJECTIVES:A post hoc analysis of pooled data from two quetiapine monotherapy clinical trials was conducted to evaluate the efficacy and tolerability of quetiapine therapy (twice daily, 400-800 mg/day) among bipolar manic adults aged 55 years and older. The primary efficacy endpoint was the change from baseline in Youn...

    journal_title:Bipolar disorders

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Sajatovic M,Calabrese JR,Mullen J

    更新日期:2008-09-01 00:00:00

  • Is first episode mania associated with grey matter abnormalities? We are not sure!

    abstract::With great interest, we have read the recent paper by Keramatian and colleagues entitled "Grey Matter Abnormalities in First Episode Mania: A Systematic Review and Meta-analysis of Voxel-Based Morphometry Studies" in Bipolar Disorders1 . The authors systematically reviewed 15 voxel-based morphometry (VBM) studies and ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Sheng L,Ma H,Dai Z,Yao L,Hu J

    更新日期:2021-01-29 00:00:00

  • The effectiveness of restarted lithium treatment after discontinuation: reviewing the evidence for discontinuation-induced refractoriness.

    abstract:OBJECTIVES:We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients. METHODS:We conducted literature searches in the Pubmed, Embase, Cochrane, and PsycINFO dat...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审


    authors: de Vries C,van Bergen A,Regeer EJ,Benthem E,Kupka RW,Boks MP

    更新日期:2013-09-01 00:00:00

  • Differential failure to deactivate the default mode network in unipolar and bipolar depression.

    abstract:OBJECTIVES:Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS:Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healt...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Rodríguez-Cano E,Alonso-Lana S,Sarró S,Fernández-Corcuera P,Goikolea JM,Vieta E,Maristany T,Salvador R,McKenna PJ,Pomarol-Clotet E

    更新日期:2017-08-01 00:00:00

  • A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder.

    abstract:OBJECTIVES:To evaluate the antimanic efficacy and safety of paliperidone extended-release (ER) tablets in patients with bipolar I disorder. METHODS:This study included a 3-week, double-blind, acute treatment phase (paliperidone ER versus placebo, with quetiapine as control), and a 9-week, double-blind, maintenance pha...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vieta E,Nuamah IF,Lim P,Yuen EC,Palumbo JM,Hough DW,Berwaerts J

    更新日期:2010-05-01 00:00:00

  • Laterality of pain in migraine with comorbid unipolar depressive and bipolar II disorders.

    abstract:OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Fasmer OB,Oedegaard KJ

    更新日期:2002-10-01 00:00:00

  • Impact of sunlight on the age of onset of bipolar disorder.

    abstract:OBJECTIVE:Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset. METHOD:Data ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Bauer M,Glenn T,Alda M,Andreassen OA,Ardau R,Bellivier F,Berk M,Bjella TD,Bossini L,Del Zompo M,Dodd S,Fagiolini A,Frye MA,Gonzalez-Pinto A,Henry C,Kapczinski F,Kliwicki S,König B,Kunz M,Lafer B,Lopez-Jaramillo C

    更新日期:2012-09-01 00:00:00

  • Equally increased risk for metabolic syndrome in patients with bipolar disorder and schizophrenia treated with second-generation antipsychotics.

    abstract:OBJECTIVE:Although second-generation antipsychotics (SGAs) are widely used in treating schizophrenia and bipolar disorder, their effects on dyslipidemia, glucose intolerance, metabolic syndrome (MetS), and coronary heart disease (CHD) risk are less well documented for bipolar disorder. We compared bipolar disorder and ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章


    authors: Correll CU,Frederickson AM,Kane JM,Manu P

    更新日期:2008-11-01 00:00:00

  • Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo.

    abstract::It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审


    authors: Chen G,Masana MI,Manji HK

    更新日期:2000-09-01 00:00:00