Is first episode mania associated with grey matter abnormalities? We are not sure!

abstract：OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...

journal_title：Bipolar disorders

authors： Ferrier IN,Chowdhury R,Thompson JM,Watson S,Young AH

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) has been associated with impairment in affective processing during depressive and manic states; however, there are limited data as to whether this population exhibits such difficulty during stable periods. We examined the pattern of affective processing in stable BD patients and compare...

journal_title：Bipolar disorders

authors： Gopin CB,Burdick KE,Derosse P,Goldberg TE,Malhotra AK

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. METHODS:A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipo...

journal_title：Bipolar disorders

authors： Payne JL,MacKinnon DF,Mondimore FM,McInnis MG,Schweizer B,Zamoiski RB,McMahon FJ,Nurnberger JI Jr,Rice JP,Scheftner W,Coryell W,Berrettini WH,Kelsoe JR,Byerley W,Gershon ES,DePaulo JR Jr,Potash JB

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Bipolar disorder (BD) is a common and highly disabling disease characterized by substantial cognitive and functional impairment. The exact neurobiological mechanisms underlying the expression of symptoms in this condition remain unknown but there is growing evidence that glutamate might play an important rol...

journal_title：Bipolar disorders

authors： Gigante AD,Bond DJ,Lafer B,Lam RW,Young LT,Yatham LN

更新日期：2012-08-01 00:00:00

abstract：:The widely held clinical view of 'antidepressants' as highly effective and specific for the treatment of all types of depressive disorders is exaggerated. This sobering conclusion is supported by recent findings from the NIMH-sponsored STEP-BD and STAR*D projects. Antidepressants have limited short-term efficacy in un...

journal_title：Bipolar disorders

authors： Ghaemi SN

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structure...

journal_title：Bipolar disorders

authors： MacMaster FP,Langevin LM,Jaworska N,Kemp A,Sembo M

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative th...

journal_title：Bipolar disorders

authors： Malhi GS,Outhred T,Das P,Morris G,Hamilton A,Mannie Z

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Studies into social cognition in psychiatric disorders have recently been expanded to address the question of whether or not theory of mind (ToM), i.e., the ability to represent ones own and others mental states, is impaired in bipolar affective disorder (BPD). Results have been mixed so far, mainly due to p...

journal_title：Bipolar disorders

authors： Wolf F,Brüne M,Assion HJ

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written ...

journal_title：Bipolar disorders

authors： Misra S,Socherman R,Park BS,Hauser P,Ganzini L

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Depression research historically uses both self- and clinician ratings of symptoms with significant and substantial correlations. It is often assumed that manic patients lack insight and cannot accurately report their symptoms. This delayed the development of self-rating scales for mania, but several scales ...

journal_title：Bipolar disorders

authors： Meyer TD,Crist N,La Rosa N,Ye B,Soares JC,Bauer IE

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD). METHODS:Adolescents (n = 80), between the ages of 12 and 21 years (mean = 15.6, standard deviation = 2.3), hospitalized for their initial manic or mixed episode of BD, were ev...

journal_title：Bipolar disorders

authors： Barzman DH,DelBello MP,Fleck DE,Lehmkuhl H,Strakowski SM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and...

journal_title：Bipolar disorders

authors： Miskowiak KW,Burdick KE,Martinez-Aran A,Bonnin CM,Bowie CR,Carvalho AF,Gallagher P,Lafer B,López-Jaramillo C,Sumiyoshi T,McIntyre RS,Schaffer A,Porter RJ,Purdon S,Torres IJ,Yatham LN,Young AH,Kessing LV,Vieta E

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...

journal_title：Bipolar disorders

authors： Singh J,Mattoo SK,Sharan P,Basu D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...

journal_title：Bipolar disorders

authors： McKenna BS,Sutherland AN,Legenkaya AP,Eyler LT

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in i...

journal_title：Bipolar disorders

authors： Kamath V,Paksarian D,Cui L,Moberg PJ,Turetsky BI,Merikangas KR

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To develop a cognitive behavioral intervention for adolescents with bipolar disorders, test its feasibility and preliminary efficacy. METHODS:Based on existing research, a manualized, individually delivered cognitive behavioral intervention was developed and tested with adolescents with bipolar disorders as...

journal_title：Bipolar disorders

authors： Feeny NC,Danielson CK,Schwartz L,Youngstrom EA,Findling RL

更新日期：2006-10-01 00:00:00

abstract：AIMS:To systematically review the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)-bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognit...

journal_title：Bipolar disorders

authors： Gottlieb JF,Benedetti F,Geoffroy PA,Henriksen TEG,Lam RW,Murray G,Phelps J,Sit D,Swartz HA,Crowe M,Etain B,Frank E,Goel N,Haarman BCM,Inder M,Kallestad H,Jae Kim S,Martiny K,Meesters Y,Porter R,Riemersma-van der L

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:The serotonin hypothesis plays a critical role in the etiology of bipolar disorder (BD). Although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limit...

journal_title：Bipolar disorders

authors： Hsu JW,Lirng JF,Wang SJ,Lin CL,Yang KC,Liao MH,Chou YH

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:We conducted a study of clinical presentation and family history in patients responsive to either of two commonly used mood stabilizers, lithium and lamotrigine. METHODS:The sample included 164 subjects from 21 families of bipolar probands, 14 responders to lithium and seven to lamotrigine. Diagnostic inform...

journal_title：Bipolar disorders

authors： Passmore MJ,Garnham J,Duffy A,MacDougall M,Munro A,Slaney C,Teehan A,Alda M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Several studies have challenged the traditional unipolar-bipolar dichotomy in favor of a more dimensional approach. OBJECTIVE:To evaluate the differences in mood spectrum between patients with bipolar disorder (BD) and major depressive disorder (MDD) during a major depressive episode (MDE). METHOD:Study pa...

journal_title：Bipolar disorders

authors： Cuomo A,Aguglia A,Aguglia E,Bolognesi S,Goracci A,Maina G,Mineo L,Rucci P,Sillari S,Fagiolini A

更新日期：2020-06-01 00:00:00

abstract：:Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...

journal_title：Bipolar disorders

authors： Chuang DM,Chen RW,Chalecka-Franaszek E,Ren M,Hashimoto R,Senatorov V,Kanai H,Hough C,Hiroi T,Leeds P

更新日期：2002-04-01 00:00:00

abstract：:The quality of life (QoL) construct is becoming more prominent in bipolar disorder (BD) research and practice. Uptake of the construct parallels an earlier trend in schizophrenia research, and coincides with growing interest in psychosocial components of BD's aetiology, phenomenology, and treatment. We argue that, alt...

journal_title：Bipolar disorders

authors： Murray G,Michalak EE

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...

journal_title：Bipolar disorders

authors： Regenold WT,D'Agostino CA,Ramesh N,Hasnain M,Roys S,Gullapalli RP

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. METHODS:This paper pro...

journal_title：Bipolar disorders

authors： Van Rheenen TE,Lewandowski KE,Bauer IE,Kapczinski F,Miskowiak K,Burdick KE,Balanzá-Martínez V

更新日期：2020-02-01 00:00:00

abstract：:Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...

journal_title：Bipolar disorders

authors： Savitz J,Solms M,Ramesar R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Previous studies have indicated abnormalities in response flexibility in pediatric bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of behavioral and emotional dysregulation that is characteristic of BD, since depressed and manic patients respond inflexibly to emotiona...

journal_title：Bipolar disorders

authors： Nelson EE,Vinton DT,Berghorst L,Towbin KE,Hommer RE,Dickstein DP,Rich BA,Brotman MA,Pine DS,Leibenluft E

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To assess rates of conversion to bipolar spectrum disorder (BPSD) and risk factors associated with conversion in children with depressive spectrum disorders (DSD) and transient manic symptoms (TMS) over 18 months. TMS are manic-like symptoms of insufficient duration or number to warrant a diagnosis of BPSD. ...

journal_title：Bipolar disorders

authors： Nadkarni RB,Fristad MA

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from nine population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and de...

journal_title：Bipolar disorders

authors： Angst J,Rössler W,Ajdacic-Gross V,Angst F,Wittchen HU,Lieb R,Beesdo-Baum K,Asselmann E,Merikangas KR,Cui L,Andrade LH,Viana MC,Lamers F,Penninx BW,de Azevedo Cardoso T,Jansen K,Dias de Mattos Souza L,Azevedo da Silva R

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear. METHODS:In this prospective observational study of 116 individuals with bipolar disorder, we examined the association between smoking and suic...

journal_title：Bipolar disorders

authors： Ostacher MJ,Lebeau RT,Perlis RH,Nierenberg AA,Lund HG,Moshier SJ,Sachs GS,Simon NM

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Significant debate exists on whether early onset bipolar disorder is mistakenly attributed to attention deficit hyperactivity disorder (ADHD) or conduct disorder (CD), or whether ADHD and CD are frequently misdiagnosed as mania. We review the literature on the extent to which these disorders can be reliably ...

journal_title：Bipolar disorders

authors： Kim EY,Miklowitz DJ

更新日期：2002-08-01 00:00:00