Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta-analysis of randomized controlled trials.

Abstract:

OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of the dopaminergic-enhancing agent modafinil/armodafinil (MoArm) as adjunctive treatment for bipolar depression. METHODS:A comprehensive search of major electronic databases was conducted to identify randomized controlled trials (RCTs) of adjunctive MoArm that included patients with bipolar I (BP-I) or bipolar II (BP-II) depression. Data for response/remission and all-cause discontinuation were analyzed. Effect size was summarized by relative risk (RR) using a random effect model. RESULTS:Of 58 studies, five RCTs (N = 795 drug, N = 792 placebo) met inclusion criteria. Four armodafinil studies included only BP-I patients and one modafinil study included both bipolar subtypes with limited heterogeneity (I2  = 34%, P = .19; I2  = 18%, P = .30). Compared to placebo, augmentation with MoArm was associated with significantly greater rates of treatment response (RR, 1.18; 95% CI, 1.01-1.37; P = .03) and remission (RR, 1.38; 95% CI, 1.10-1.73; P = .005). All-cause discontinuation was not different than placebo (RR, 1.08; 95% CI, 0.89-1.30; P = .45) with no evidence of increased risk of mood switch or suicide attempts with MoArm (RR, 0.99; 95% CI, 0.39-2.5; P = .98; RR, 1.02; 95% CI, 0.37-2.85; P = .97). CONCLUSION:This narrower scope meta-analysis of one drug for one disease suggests that adjunctive MoArm may represent a novel therapeutic intervention. Further studies delineating the subtypes of bipolar depression responsive to these novel dopaminergic-enhancing agents are encouraged.

journal_name

Bipolar Disord

journal_title

Bipolar disorders

authors

Nunez NA,Singh B,Romo-Nava F,Joseph B,Veldic M,Cuellar-Barboza A,Cabello Arreola A,Vande Voort JL,Croarkin P,Moore KM,Biernacka J,McElroy SL,Frye MA

doi

10.1111/bdi.12859

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

109-120

issue

2

eissn

1398-5647

issn

1399-5618

journal_volume

22

pub_type

杂志文章,meta分析
  • Cognitive behavioral rehabilitation for bipolar disorder patients: A randomized controlled trial.

    abstract:OBJECTIVES:Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions hav...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bdi.12784

    authors: Gomes BC,Rocca CC,Belizario GO,de B F Fernandes F,Valois I,Olmo GC,Fachin RVP,Farhat LC,Lafer B

    更新日期:2019-11-01 00:00:00

  • Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder.

    abstract:OBJECTIVES:The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study. METHODS:Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either...

    journal_title:Bipolar disorders

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-5618.2006.00335.x

    authors: Sharma V,Smith A,Mazmanian D

    更新日期:2006-08-01 00:00:00

  • Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder.

    abstract:OBJECTIVES:Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present study...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12126

    authors: McKenna BS,Sutherland AN,Legenkaya AP,Eyler LT

    更新日期:2014-05-01 00:00:00

  • The role of atypical antipsychotics in bipolar depression and anxiety disorders.

    abstract::Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increas...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-2406.2003.00061.x

    authors: McIntyre R,Katzman M

    更新日期:2003-01-01 00:00:00

  • Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence.

    abstract:OBJECTIVES:Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. METHODS:This paper pro...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1111/bdi.12821

    authors: Van Rheenen TE,Lewandowski KE,Bauer IE,Kapczinski F,Miskowiak K,Burdick KE,Balanzá-Martínez V

    更新日期:2020-02-01 00:00:00

  • Childhood mania, attention deficit hyperactivity disorder and conduct disorder: a critical review of diagnostic dilemmas.

    abstract:OBJECTIVES:Significant debate exists on whether early onset bipolar disorder is mistakenly attributed to attention deficit hyperactivity disorder (ADHD) or conduct disorder (CD), or whether ADHD and CD are frequently misdiagnosed as mania. We review the literature on the extent to which these disorders can be reliably ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2002.01191.x

    authors: Kim EY,Miklowitz DJ

    更新日期:2002-08-01 00:00:00

  • Laterality of pain in migraine with comorbid unipolar depressive and bipolar II disorders.

    abstract:OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1034/j.1399-5618.2002.01226.x

    authors: Fasmer OB,Oedegaard KJ

    更新日期:2002-10-01 00:00:00

  • Prevalence of the Child Behavior Checklist-pediatric bipolar disorder phenotype in a German general population sample.

    abstract:BACKGROUND:In children with pediatric bipolar disorder (PBD), a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression has been identified on the Child Behavior Checklist (CBCL-PBD profile). In Germany, no epidemiological study has included PBD to date. OBJECTIVES:To estimate...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00463.x

    authors: Holtmann M,Bölte S,Goth K,Döpfner M,Plück J,Huss M,Fegert JM,Lehmkuhl G,Schmeck K,Poustka F

    更新日期:2007-12-01 00:00:00

  • Cortical thickness differences between bipolar depression and major depressive disorder.

    abstract:OBJECTIVES:Bipolar disorder (BD) is a psychiatric disorder with high morbidity and mortality that cannot be distinguished from major depressive disorder (MDD) until the first manic episode. A biomarker able to differentiate BD and MDD could help clinicians avoid risks of treating BD with antidepressants without mood st...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12175

    authors: Lan MJ,Chhetry BT,Oquendo MA,Sublette ME,Sullivan G,Mann JJ,Parsey RV

    更新日期:2014-06-01 00:00:00

  • Is first episode mania associated with grey matter abnormalities? We are not sure!

    abstract::With great interest, we have read the recent paper by Keramatian and colleagues entitled "Grey Matter Abnormalities in First Episode Mania: A Systematic Review and Meta-analysis of Voxel-Based Morphometry Studies" in Bipolar Disorders1 . The authors systematically reviewed 15 voxel-based morphometry (VBM) studies and ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.13048

    authors: Sheng L,Ma H,Dai Z,Yao L,Hu J

    更新日期:2021-01-29 00:00:00

  • Cognitive remediation therapy for patients with bipolar disorder: A randomised proof-of-concept trial.

    abstract:OBJECTIVES:Cognitive remediation therapy (CRT) may benefit people with bipolar disorder type I and II for whom cognitive impairment is a major contributor to disability. Extensive research has demonstrated CRT to improve cognition and psychosocial functioning in people with different diagnoses, but randomised trials of...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12968

    authors: Strawbridge R,Tsapekos D,Hodsoll J,Mantingh T,Yalin N,McCrone P,Boadu J,Macritchie K,Cella M,Reeder C,Fish J,Wykes T,Young AH

    更新日期:2020-06-24 00:00:00

  • Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

    abstract:OBJECTIVES:To compare the clinical features and course of major depressive episodes (MDEs) occurring in subjects with bipolar I disorder (BD-I), bipolar II disorder (BD-II), and major depressive disorder (MDD). METHODS:Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (2001-2002)...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2012.01009.x

    authors: Moreno C,Hasin DS,Arango C,Oquendo MA,Vieta E,Liu S,Grant BF,Blanco C

    更新日期:2012-05-01 00:00:00

  • Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania.

    abstract:BACKGROUND:Acute mania can be modeled in animals using D-amphetamine (AMPH). Acute AMPH injections are associated with monoamine depletion, loss of neurofilaments and neurite degeneration. However, the precise mechanisms underlying AMPH-induced neurotoxicity are still unclear. Several studies have demonstrated that oxi...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2006.00318.x

    authors: Frey BN,Martins MR,Petronilho FC,Dal-Pizzol F,Quevedo J,Kapczinski F

    更新日期:2006-06-01 00:00:00

  • Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report.

    abstract::The Diagnostic Guidelines Task Force of the International Society for Bipolar Disorders (ISBD) presents in this document and this special issue a summary of the current nosological status of bipolar illness, a discussion of possible revisions to current DSM-IV and ICD-10 definitions, an examination of the relevant lit...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1399-5618.2007.00556.x

    authors: Ghaemi SN,Bauer M,Cassidy F,Malhi GS,Mitchell P,Phelps J,Vieta E,Youngstrom E,ISBD Diagnostic Guidelines Task Force.

    更新日期:2008-02-01 00:00:00

  • Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study.

    abstract:OBJECTIVES:To compare the concentrations of high-energy phosphorus metabolites associated with mitochondrial function in the frontal lobe of depressed adolescents with bipolar disorder (BD) and healthy controls (HC). METHODS:We used in vivo phosphorus-31 magnetic resonance spectroscopy ((31) P-MRS) at 3 Tesla to measu...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2012.01040.x

    authors: Shi XF,Kondo DG,Sung YH,Hellem TL,Fiedler KK,Jeong EK,Huber RS,Renshaw PF

    更新日期:2012-09-01 00:00:00

  • Calcium channel antagonists for the treatment of bipolar disorder.

    abstract::Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.2000.020204.x

    authors: Levy NA,Janicak PG

    更新日期:2000-06-01 00:00:00

  • Influence of mood state on capacity to consent to research in patients with bipolar disorder.

    abstract:OBJECTIVES:Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. METHODS:Hypothetical studies were presented as written ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00525.x

    authors: Misra S,Socherman R,Park BS,Hauser P,Ganzini L

    更新日期:2008-03-01 00:00:00

  • Fronto-temporal function may distinguish bipolar disorder from schizophrenia.

    abstract:OBJECTIVES:There is evidence for differential neural alterations within the prefrontal cortex (PFC) in bipolar disorder I (BDI) and schizophrenia that may translate into different cognitive deficits. Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tas...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2006.00274.x

    authors: Frangou S,Dakhil N,Landau S,Kumari V

    更新日期:2006-02-01 00:00:00

  • Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study.

    abstract:OBJECTIVES:While the pathophysiology of bipolar disorder (BD) remains to be elucidated, postmortem and neuroimaging studies have suggested that abnormalities in the dorsolateral prefrontal cortex (DLPFC) are implicated. We compared the levels of specific brain chemicals of interest measured with proton magnetic resonan...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2007.00454.x

    authors: Frey BN,Stanley JA,Nery FG,Monkul ES,Nicoletti MA,Chen HH,Hatch JP,Caetano SC,Ortiz O,Kapczinski F,Soares JC

    更新日期:2007-06-01 00:00:00

  • Prediction of pediatric bipolar disorder using neuroanatomical signatures of the amygdala.

    abstract:OBJECTIVES:Pediatric bipolar disorder is currently diagnosed based on signs and symptoms, and without objective diagnostic biomarkers. In the present study, we investigated the utility of structural neuroanatomical signatures of the amygdala to objectively differentiate individual subjects with pediatric bipolar disord...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12222

    authors: Mwangi B,Spiker D,Zunta-Soares GB,Soares JC

    更新日期:2014-11-01 00:00:00

  • Diffusion-weighted magnetic resonance imaging of white matter in bipolar disorder: a pilot study.

    abstract:OBJECTIVE:Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coe...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2006.00281.x

    authors: Regenold WT,D'Agostino CA,Ramesh N,Hasnain M,Roys S,Gullapalli RP

    更新日期:2006-04-01 00:00:00

  • Electroencephalographic patterns of lithium poisoning: a study of the effect/concentration relationships in the rat.

    abstract:OBJECTIVES:Lithium overdose may result in encephalopathy and electroencephalographic abnormalities. Three poisoning patterns have been identified based on the ingested dose, previous treatment duration and renal function. Whether the severity of lithium-induced encephalopathy depends on the poisoning pattern has not be...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12482

    authors: Hanak AS,Malissin I,Poupon J,Risède P,Chevillard L,Mégarbane B

    更新日期:2017-03-01 00:00:00

  • A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder.

    abstract:OBJECTIVES:To evaluate the antimanic efficacy and safety of paliperidone extended-release (ER) tablets in patients with bipolar I disorder. METHODS:This study included a 3-week, double-blind, acute treatment phase (paliperidone ER versus placebo, with quetiapine as control), and a 9-week, double-blind, maintenance pha...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-5618.2010.00815.x

    authors: Vieta E,Nuamah IF,Lim P,Yuen EC,Palumbo JM,Hough DW,Berwaerts J

    更新日期:2010-05-01 00:00:00

  • Allostatic load, emotional hyper-reactivity, and functioning in individuals with bipolar disorder.

    abstract:OBJECTIVES:Diagnosis and management of bipolar disorder (BD) are limited by the absence of available biomarkers. Allostatic load (AL) represents the strain that stress, including the effects of acute phases and inter-episode chronic mood instability, exerts on interconnected biological systems. This study aimed to oper...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12927

    authors: Dargél AA,Volant S,Brietzke E,Etain B,Olié E,Azorin JM,Gard S,Bellivier F,Bougerol T,Kahn JP,Roux P,Aubin V,Courtet P,Leboyer M,Henry C,FACE-BD collaborators.

    更新日期:2020-11-01 00:00:00

  • Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs.

    abstract::Inositol metabolism is well characterized in yeast at a molecular level, and yeast is the only eukaryote in which genetic, molecular and functional genomic approaches to identify lithium. valproate and inositol targets may be combined readily. It has been shown that lithium inhibits yeast inositol monophosphatase (enc...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-5618.4.s1.2.x

    authors: Agam G,Shamir A,Shaltiel G,Greenberg ML

    更新日期:2002-01-01 00:00:00

  • Cigarette smoking is associated with suicidality in bipolar disorder.

    abstract:OBJECTIVES:Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear. METHODS:In this prospective observational study of 116 individuals with bipolar disorder, we examined the association between smoking and suic...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2009.00744.x

    authors: Ostacher MJ,Lebeau RT,Perlis RH,Nierenberg AA,Lund HG,Moshier SJ,Sachs GS,Simon NM

    更新日期:2009-11-01 00:00:00

  • The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology.

    abstract:AIMS:To systematically review the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)-bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognit...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12847

    authors: Gottlieb JF,Benedetti F,Geoffroy PA,Henriksen TEG,Lam RW,Murray G,Phelps J,Sit D,Swartz HA,Crowe M,Etain B,Frank E,Goel N,Haarman BCM,Inder M,Kallestad H,Jae Kim S,Martiny K,Meesters Y,Porter R,Riemersma-van der L

    更新日期:2019-12-01 00:00:00

  • MEG auditory evoked fields suggest altered structural/functional asymmetry in primary but not secondary auditory cortex in bipolar disorder.

    abstract:OBJECTIVES:Objective physiological indices independently characterizing affective and schizophreniform psychoses would contribute to our understanding of the nature of their relationships. Magnetoencephalography (MEG)-based metrics of altered structural/functional asymmetry in the superior temporal gyrus have previousl...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/j.1399-5618.2009.00701.x

    authors: Reite M,Teale P,Rojas DC,Reite E,Asherin R,Hernandez O

    更新日期:2009-06-01 00:00:00

  • Temporal association as a prerequisite factor of valsartan-induced lithium toxicity.

    abstract:OBJECTIVES:Lithium is often the mood stabilizer of choice for the treatment of type I bipolar disorder. However, side effects as well as the narrow therapeutic dosing range often complicate its use. Lithium toxicity can be fatal and its serum level needs to be closely monitored, especially at the time of introduction a...

    journal_title:Bipolar disorders

    pub_type: 杂志文章

    doi:10.1111/bdi.12174

    authors: Lazarczyk MJ,Giannakopoulos P

    更新日期:2014-09-01 00:00:00

  • Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine.

    abstract:OBJECTIVE:The present study evaluated inhaled loxapine for the acute treatment of agitation in patients with bipolar I disorder. METHODS:A Phase 3, randomized, double blind, placebo-controlled, parallel group inpatient study was performed at 17 psychiatric research facilities. Agitated patients (N=314) with bipolar I ...

    journal_title:Bipolar disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-5618.2011.00975.x

    authors: Kwentus J,Riesenberg RA,Marandi M,Manning RA,Allen MH,Fishman RS,Spyker DA,Kehne JH,Cassella JV

    更新日期:2012-02-01 00:00:00